Otay Mesa

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area, or simply enjoy its restaurants.
See properties

Things to do

Kayak on the San Diego Bay

Kayak on the San Diego Bay

P1,231
per adult
Kayak on the San Diego Bay
Taco Tuesday Hop to Tijuana from San Diego

Taco Tuesday Hop to Tijuana from San Diego

P5,107
per adult
Taco Tuesday Hop to Tijuana from San Diego
Guadalupe Wine Valley Tour

Guadalupe Wine Valley Tour

P19,691
per traveler
Guadalupe Wine Valley Tour
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

P6,092
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Stand up Paddle Board Lesson on The San Diego Bay

Stand up Paddle Board Lesson on The San Diego Bay

P1,538
per adult
100% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
Wine Route including Tastings

Wine Route including Tastings

P15,322
per adult
Wine Route including Tastings
See all activities in San Diego

Top hotels in Otay Mesa

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is P15,783 per night from Aug 23 to Aug 24
P15,783
P21,415 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is P9,502 per night from Aug 6 to Aug 7
P9,502
P13,166 total
Aug 6 - Aug 7
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,242 reviews)
"It was a very nice property and conveniently located. The only inconvenience was that our room was in tower three, which is not attached to the main building so it was more inconvenient to get to the fitness room and the pool. The rooms were spacious and well maintained.I loved that there was a water ..."

Reviewed on Jul 25, 2026

Wyndham San Diego Bayside
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd Coronado CA
The price is P17,295 per night from Aug 16 to Aug 17
P17,295
P22,281 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Loews Coronado Bay Resort
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave Coronado CA
The price is P31,392 per night from Aug 18 to Aug 19
P31,392
P38,282 total
Aug 18 - Aug 19
includes taxes & fees
Book a stay at this beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,019 reviews)
"Everything was great, except our experience at our Anniversary dinner at “Serea”."

Reviewed on Jul 25, 2026

Hotel del Coronado, Curio Collection by Hilton
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
The price is P7,181 per night from Jul 26 to Jul 27
P7,181
P8,254 total
Jul 26 - Jul 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,728 reviews)
"Clean comfortable room, good location. Limited walkable food options. Weak plumbing, odd sounds from pipes all morning… otherwise pretty quiet save for the return of the late night party people."

Reviewed on Jul 24, 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is P10,394 per night from Jul 27 to Jul 28
P10,394
P15,034 total
Jul 27 - Jul 28
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,079 reviews)
"No smart tv's"

Reviewed on Jul 25, 2026

Hard Rock Hotel San Diego
See all 4,940 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Otay Mesa