Otay Mesa

San Diego


Popular places to visit

Things to do


Top hotels in Otay Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is P8,845 per night from Oct 5 to Oct 6
P8,845
P11,941 total
Oct 5 - Oct 6
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,955 reviews)
"Friendly helpful staff. Good location"

Reviewed on Sep 26, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is P12,746 per night from Oct 4 to Oct 5
P12,746
P17,944 total
Oct 4 - Oct 5
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,819 reviews)
"The hotel is nice but more tailored for the convention fare & less of a resort ambiance. Service was efficient yet impersonal & why no concierge? They make a hotel experience."

Reviewed on Sep 22, 2025

Manchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is P6,937 per night from Oct 7 to Oct 8
P6,937
P8,044 total
Oct 7 - Oct 8
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (475 reviews)
"Clean room"

Reviewed on Sep 27, 2025

The DEXTRO Little Italy, BW Premier Collection
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8.2/10 Very Good! (2,122 reviews)
"Clean room, friendly staff and mall a few minutes away."

Reviewed on Sep 28, 2025

Handlery Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is P8,360 per night from Oct 29 to Oct 30
P8,360
P10,774 total
Oct 29 - Oct 30
includes taxes & fees
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...
8.8/10 Excellent! (3,779 reviews)
"Yes it did"

Reviewed on Sep 28, 2025

The Dana on Mission Bay
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4 out of 5
830 Sixth Avenue, San Diego, CA
The price is P6,757 per night from Oct 23 to Oct 24
P6,757
P7,834 total
Oct 23 - Oct 24
includes taxes & fees
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...
8.6/10 Excellent! (1,844 reviews)
"Room was absolutely stifling! Air conditioning did not cool it down at all! Could not sleep."

Reviewed on Sep 28, 2025

Palihotel San Diego Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Petco Park featuring a statue or sculpture

East Village

Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
Gaslamp Quarter which includes signage, a bar and night scenes

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

Gaslamp Quarter
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Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Downtown San Diego
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North Park

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
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Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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Del Cerro

Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.

Del Cerro