Otay Mesa Hotels near San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very Good, (1,739 reviews)
"great breakfast and nice staff"
United States
rosita
The price is P8,025
P9,129 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Friendly staff, clean room fair rates"
Canada
Mikael
The price is P6,621
P7,531 total
includes taxes & fees
May 25 - May 26
Quality Suites San Diego Otay Mesa

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,831 reviews)
"Great resort "
United States
Ines
The price is P9,198
P10,136 total
includes taxes & fees
May 20 - May 21
Best Western Plus Marina Gateway Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,287 reviews)
"Everything was very pleasant,the place was super clean, and the breakfast was delicious👍"
United States
Nancy
The price is P7,550
P8,588 total
includes taxes & fees
May 27 - May 28
Best Western Americana Inn

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
13.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1,002 reviews)
"Good breakfast items, large rooms, good service"
United States
Catherine A
The price is P8,834
P10,088 total
includes taxes & fees
May 25 - May 26
Hampton Inn & Suites Imperial Beach San Diego

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,931 reviews)
"It is a perfect hotel if breakfast is included in the stay."
United States
Tugba
The price is P6,087
P7,436 total
includes taxes & fees
May 26 - May 27
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,654 reviews)
"This is a must stay place in San Diego"
United States
Kristi
The price is P15,371
P17,669 total
includes taxes & fees
May 21 - May 22
Lafayette Hotel & Club

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,099 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is P11,612
P12,796 total
includes taxes & fees
Jun 7 - Jun 8
Ayres Hotel San Diego South - Chula Vista

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,164 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is P8,343
P9,178 total
includes taxes & fees
May 25 - May 26
Holiday Inn Express San Diego South - Chula Vista by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very Good, (3,529 reviews)
"Excellent food, friendly staff, easy check-in, and beautiful setting. "
United States
Emily
The price is P10,433
P15,114 total
includes taxes & fees
May 24 - May 25
Sheraton San Diego Resort

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,503 reviews)
"Laundry room was extremely clean breakfast pretty nice staff was excellent "
United States
Victoria
The price is P6,433
P7,089 total
includes taxes & fees
Jun 14 - Jun 15
Comfort Inn Chula Vista San Diego South

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,620 reviews)
"Great stay"
United States
Helda
The price is P6,612
P7,273 total
includes taxes & fees
May 25 - May 26
La Quinta Inn by Wyndham San Diego Chula Vista

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (650 reviews)
"Best hotel ever!"
United States
Nicholas
The price is P13,219
P14,567 total
includes taxes & fees
May 31 - Jun 1
SpringHill Suites by Marriott Chula Vista Eastlake

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,676 reviews)
"Staff was amazing!"
United States
Jamilett
The price is P5,277
P5,815 total
includes taxes & fees
May 20 - May 21
Motel 6 El Cajon, CA - San Diego

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,721 reviews)
"Great hotel"
United States
Beatrice
The price is P10,811
P12,426 total
includes taxes & fees
May 25 - May 26
Hampton Inn & Suites San Diego Airport Liberty Station

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very Good, (1,653 reviews)
"Clean room, friendly and nice staff, easy parking and safe "
United States
Erik
The price is P4,692
P5,345 total
includes taxes & fees
May 20 - May 21
Studio 6 Suites San Ysidro, CA -San Diego South Bay

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,006 reviews)
"Love it great place"
United States
Derek
The price is P11,227
P12,905 total
includes taxes & fees
May 26 - May 27
TownePlace Suites by Marriott San Diego Airport/Liberty Station

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,007 reviews)
"Clean room, clean property, kind staff, great breakfast, very spacious rooms."
United States
Sergio
The price is P8,604
P9,464 total
includes taxes & fees
May 26 - May 27
Best Western Plus La Mesa San Diego

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,060 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is P8,703
P10,003 total
includes taxes & fees
May 26 - May 27
Holiday Inn Express San Diego Airport - Old Town by IHG

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,446 reviews)
"Perfect place for a family trip "
United States
Krystal
The price is P12,902
P18,095 total
includes taxes & fees
May 25 - May 26
San Diego Mission Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.