Otay Mesa Hotels near San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1,651 reviews)
"Clean, great breakfast, good service."
United States
Sara
The price is P7,486
P8,515 total
includes taxes & fees
Mar 8 - Mar 9
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is P6,047
P6,878 total
includes taxes & fees
Mar 8 - Mar 9
Quality Suites San Diego Otay Mesa

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,540 reviews)
"We only stayed one night but it was comfortable and clean "
United States
Brandy
The price is P3,792
P4,180 total
includes taxes & fees
Mar 20 - Mar 21
Motel 6 El Cajon, CA - San Diego

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,615 reviews)
"Clean rooms and the breakfast was amazing "
United States
Vanessa
The price is P5,988
P6,587 total
includes taxes & fees
Feb 22 - Feb 23
Best Western Chula Vista/Otay Valley Hotel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,742 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,735 reviews)
"My favorite place to stay"
United States
Rubidia
The price is P7,845
P8,645 total
includes taxes & fees
Feb 18 - Feb 19
Best Western Plus Marina Gateway Hotel

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,120 reviews)
"Great location "
United States
Irma
The price is P11,960
P13,179 total
includes taxes & fees
Feb 22 - Feb 23
Ayres Hotel San Diego South - Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,351 reviews)
"Love this place. "
United States
kristy
The price is P5,990
P6,601 total
includes taxes & fees
Mar 1 - Mar 2
Comfort Inn Chula Vista San Diego South

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.6 out of 10, Good, (1,006 reviews)
"Great service.room was clean and included breakfast "
United States
Antonio
The price is P4,596
P5,064 total
includes taxes & fees
Feb 23 - Feb 24
Days Inn by Wyndham San Diego-East/El Cajon

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (581 reviews)
"Clean room and friendly staff "
United States
Michael
The price is P10,445
P11,510 total
includes taxes & fees
Mar 15 - Mar 16
SpringHill Suites by Marriott Chula Vista Eastlake

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,543 reviews)
"The room was very clean and the staff was very nice."
United States
Rod
The price is P5,524
P6,077 total
includes taxes & fees
Mar 1 - Mar 2
La Quinta Inn by Wyndham San Diego Chula Vista

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very Good, (3,325 reviews)
"Love this hotel will always stay here when I come to San Diego "
United States
Darlene
The price is P11,432
P15,693 total
includes taxes & fees
Mar 11 - Mar 12
Sheraton San Diego Resort

Old Town Inn

Old Town Inn
2.5 star property
30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,806 reviews)
"Clean, friendly staff, good value, nice pool area"
Canada
Mark
Old Town Inn

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,215 reviews)
"Great stay"
United States
Elisa
The price is P6,685
P7,604 total
includes taxes & fees
Feb 18 - Feb 19
Best Western Americana Inn

Hotel Milagro

Hotel Milagro
2.0 star property
14.9 km from Otay Mesa
7.8 out of 10, Good, (1,005 reviews)
"Great frienly and welcoming staff. Clean and comfy."
United States
Raquel
The price is P3,850
P4,235 total
includes taxes & fees
Mar 2 - Mar 3
Hotel Milagro

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,010 reviews)
"Room was clean, pleasant staff and great breakfast "
United States
Wendy
The price is P6,453
P7,098 total
includes taxes & fees
Feb 22 - Feb 23
Best Western Plus La Mesa San Diego

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,727 reviews)
"Great place to stay for access to the airport, staff was super!"
Canada
Alison
The price is P9,815
P11,282 total
includes taxes & fees
Feb 27 - Feb 28
Hampton Inn & Suites San Diego Airport Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,006 reviews)
" The hotel is very clean, and the staff are friendly and helpful"
United States
Jun
The price is P9,871
P11,346 total
includes taxes & fees
Mar 8 - Mar 9
TownePlace Suites by Marriott San Diego Airport/Liberty Station

The Rambler

The Rambler
3.0 star property
14.8 km from Otay Mesa
9.2 out of 10, Wonderful, (2,054 reviews)
"Absolutely amazing stay will def be coming back!"
United States
Victor
The price is P6,668
P7,715 total
includes taxes & fees
Mar 2 - Mar 3
The Rambler

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,359 reviews)
"Good accommodations for the price point."
United States
Martin
Lamplighter Inn & Suites at SDSU
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Seaport Village and Petco Park are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Quality Suites San Diego Otay Mesa is the highest ranked property in Otay Mesa. This hotel offers free breakfast and free parking.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.