
Otay Mesa Hotels near San Diego
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
Motel 6 El Cajon, CA - San Diego
Motel 6 El Cajon, CA - San Diego
Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel
Sycuan Casino Resort
Sycuan Casino Resort
Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel
Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista
Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South
Days Inn by Wyndham San Diego-East/El Cajon
Days Inn by Wyndham San Diego-East/El Cajon
SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake
La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista
Sheraton San Diego Resort
Sheraton San Diego Resort
Best Western Americana Inn
Best Western Americana Inn
Hotel Milagro
Hotel Milagro
Best Western Plus La Mesa San Diego
Best Western Plus La Mesa San Diego
Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station
TownePlace Suites by Marriott San Diego Airport/Liberty Station
TownePlace Suites by Marriott San Diego Airport/Liberty Station
The Rambler
The Rambler
Lamplighter Inn & Suites at SDSU
Lamplighter Inn & Suites at SDSUWhere to stay in Otay Mesa

Downtown San Diego
Seaport Village and Petco Park are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

























































































