A city skyline with high-rise buildings and a bridge over a body of water.

Otay Mesa Hotels near San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Star rating

Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very Good, (1,774 reviews)
"Clean, friendly staff, great breakfast!!"
United States
Flor
The price is P8,846
P10,062 total
includes taxes & fees
Aug 2 - Aug 3
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,002 reviews)
"Very clean, bed was comfortable!"
United States
Michael A
The price is P7,009
P7,973 total
includes taxes & fees
Aug 4 - Aug 5
Quality Suites San Diego Otay Mesa

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,707 reviews)
"A good place to stay if you need a place to crash in for the night"
United States
Ivy Ruth
The price is P5,341
P5,886 total
includes taxes & fees
Jul 9 - Jul 10
Motel 6 El Cajon, CA - San Diego

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,316 reviews)
"The breakfast was great, the staff was helpful, and the room was clean and spacious!"
United States
Christopher
The price is P7,530
P8,566 total
includes taxes & fees
Jul 12 - Jul 13
Best Western Americana Inn

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 29.9 km from Otay Mesa
8.4 out of 10, Very Good, (2,066 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is P9,779
P11,241 total
includes taxes & fees
Jul 5 - Jul 6
Best Western Plus Hacienda Hotel Old Town

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very Good, (3,531 reviews)
"Great location and shuttle service to and from the airport."
Canada
Malinda
The price is P10,404
P15,073 total
includes taxes & fees
Jul 6 - Jul 7
Sheraton San Diego Resort

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,710 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is P10,551
P12,127 total
includes taxes & fees
Jul 19 - Jul 20
Hampton Inn & Suites San Diego Airport Liberty Station

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,644 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is P7,780
P8,558 total
includes taxes & fees
Jul 19 - Jul 20
La Quinta Inn by Wyndham San Diego Chula Vista

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very Good, (1,026 reviews)
"Great place to stay."
United States
Allan
The price is P5,529
P6,300 total
includes taxes & fees
Jul 7 - Jul 8
Valli Hi Motel

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,577 reviews)
"The room was comfortable and conveniently located. Breakfast was great for the cost of our stay."
United States
Arsenia P
The price is P8,256
P9,098 total
includes taxes & fees
Jul 19 - Jul 20
Comfort Inn Chula Vista San Diego South

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,995 reviews)
"Always a great stay"
United States
Jeanette
The price is P7,117
P8,567 total
includes taxes & fees
Jul 12 - Jul 13
Sycuan Casino Resort

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,096 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is P11,555
P12,733 total
includes taxes & fees
Aug 2 - Aug 3
Ayres Hotel San Diego South - Chula Vista

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,161 reviews)
"Cool vibe in an easy spot to get on and off the highway."
United States
Jami
The price is P9,153
P10,590 total
includes taxes & fees
Jul 5 - Jul 6
The Rambler Hotel

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very Good, (1,845 reviews)
"The stay was great, and breakfast was delicious"
United States
Katie
The price is P7,780
P8,573 total
includes taxes & fees
Aug 2 - Aug 3
Best Western Chula Vista/Otay Valley Hotel

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,902 reviews)
"Great stay"
United States
Cameron
The price is P9,897
P10,906 total
includes taxes & fees
Jul 19 - Jul 20
Best Western Plus Marina Gateway Hotel

Carlton Oaks Lodge, an Ascend Collection Hotel

Carlton Oaks Lodge, an Ascend Collection Hotel
3.0 star property
31.6 km from Otay Mesa
8.2 out of 10, Very Good, (1,001 reviews)
"Loved the restaurant!!"
United States
Krista
The price is P7,065
P9,798 total
includes taxes & fees
Aug 3 - Aug 4
Carlton Oaks Lodge, an Ascend Collection Hotel

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,075 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is P9,727
P11,181 total
includes taxes & fees
Jul 7 - Jul 8
Holiday Inn Express San Diego Airport - Old Town by IHG

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,005 reviews)
"Rooms were cheap clean property was clean convenient close to where I was working"
United States
James
The price is P7,310
P8,055 total
includes taxes & fees
Jul 6 - Jul 7
Days Inn by Wyndham San Diego-East/El Cajon

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,501 reviews)
"We have stayed here before, good location, clean rooms, great staff."
United States
Lance
The price is P18,407
P24,413 total
includes taxes & fees
Jul 7 - Jul 8
San Diego Mission Bay Resort

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
25 km from Otay Mesa
9.0 out of 10, Wonderful, (1,852 reviews)
"Great stay!"
United States
Miguel
The price is P12,857
P17,140 total
includes taxes & fees
Jul 5 - Jul 6
Embassy Suites by Hilton San Diego Bay Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.