Otay Mesa Hotels near San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1,683 reviews)
"Great breakfast!"
United States
Susan
The price is P6,626
P7,537 total
includes taxes & fees
May 3 - May 4
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,000 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is P6,440
P7,325 total
includes taxes & fees
Apr 26 - Apr 27
Quality Suites San Diego Otay Mesa

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very Good, (1,566 reviews)
"Good location"
United States
Joshua
The price is P4,638
P5,285 total
includes taxes & fees
Apr 5 - Apr 6
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,722 reviews)
"Great location for the airport stay"
United States
Christopher
The price is P10,548
P12,125 total
includes taxes & fees
Apr 26 - Apr 27
Hampton Inn & Suites San Diego Airport Liberty Station

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,760 reviews)
"Great hotel"
United States
Deante
The price is P8,975
P9,890 total
includes taxes & fees
Apr 5 - Apr 6
Best Western Plus Marina Gateway Hotel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,815 reviews)
"Awesome place "
United States
Jonathan
The price is P4,428
P5,598 total
includes taxes & fees
Apr 5 - Apr 6
Sycuan Casino Resort

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very Good, (1,003 reviews)
"Great location, near shops, restaurants and beaches. "
United States
Miguelina
The price is P4,634
P5,281 total
includes taxes & fees
Apr 5 - Apr 6
Valli Hi Motel

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
24.3 km from Otay Mesa
7.0 out of 10, Good, (1,375 reviews)
"If you need a quick/cheap room? This place will do. They have smoking rooms as well which is rare, and they are 420 friendly. "
United States
David
The price is P4,326
P4,770 total
includes taxes & fees
May 4 - May 5
Heritage Inn La Mesa

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,245 reviews)
"Great place and service. Will definitely stay there again. "
United States
Maria
The price is P7,368
P8,381 total
includes taxes & fees
Apr 15 - Apr 16
Best Western Americana Inn

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,182 reviews)
"Its always a great stay, thanks "
United States
Dulce
The price is P4,318
P4,749 total
includes taxes & fees
Apr 5 - Apr 6
Hotel Palmeras Chula Vista

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,106 reviews)
"Best hotel breakfast ever Rooms very spacious Nice big bathtub and nice shower I will definitely use this hotel again"
United States
Kenneth
The price is P11,886
P13,097 total
includes taxes & fees
Apr 26 - Apr 27
Ayres Hotel San Diego South - Chula Vista

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,201 reviews)
"great place"
Canada
souheil
The price is P5,909
P6,792 total
includes taxes & fees
Apr 6 - Apr 7
Wyndham Garden San Diego Near SeaWorld

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,058 reviews)
"Clean room, friendly staff, and only a 15 minute walk to Old Town. Also conveniently located close to the airport just a short shuttle drive away. "
United States
Olivia
The price is P8,192
P9,416 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express San Diego Airport - Old Town by IHG

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (616 reviews)
"By far, one of the best hotels we have stayed at! Very clean, friendly and knowledgeable front desk staff, amenities galore and right across the street from family friendly entertainment venues like play city and ninja factory. The pool was amazing - we had all a great time! "
United States
Daniel
The price is P10,359
P11,415 total
includes taxes & fees
Apr 19 - Apr 20
SpringHill Suites by Marriott Chula Vista Eastlake

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,003 reviews)
"Great accommodations, friendly staff, they met all our needs."
United States
Scott
The price is P9,165
P10,081 total
includes taxes & fees
Apr 15 - Apr 16
Best Western Plus La Mesa San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very Good, (3,420 reviews)
"Nice hotel with great location "
United States
DIANA
The price is P10,180
P14,351 total
includes taxes & fees
Apr 7 - Apr 8
Sheraton San Diego Resort

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
3.0 star property
30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (789 reviews)
"Excellence breakfast and near to downtown with best rates and wonderful supporting staff and cleanliness."
United States
Apinder
The price is P10,473
P12,039 total
includes taxes & fees
Apr 9 - Apr 10
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,002 reviews)
"Excellent place to stay."
United States
Rosario
The price is P9,677
P11,123 total
includes taxes & fees
Apr 26 - Apr 27
TownePlace Suites by Marriott San Diego Airport/Liberty Station

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.2 out of 10, Wonderful, (2,099 reviews)
"Great breakfast and friendly staff"
United States
Jeremy
The price is P6,264
P7,247 total
includes taxes & fees
Apr 14 - Apr 15
The Rambler Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,578 reviews)
"Really enjoyed our stay. "
United States
Maricruz
The price is P6,093
P6,702 total
includes taxes & fees
Apr 26 - Apr 27
La Quinta Inn by Wyndham San Diego Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.