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Otay Mesa Hotels near San Diego

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Check prices for these dates

This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,917 reviews)
"I really enjoyed my stay here. The hotel was spotless, the breakfast was delicious, and the staff were so kind and genuinely service-minded. It made me feel very welcome, and I’d be happy to stay again."
United States
Tito
The price is P8,176
P9,300 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,000 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveler
The price is P6,465
P7,354 total
includes taxes & fees
Nov 1 - Nov 2
Quality Suites San Diego Otay Mesa
A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

3. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,017 reviews)
"Great staff help me out on any questions I'll stay here again"
United States
Eric
The price is P6,882
P7,584 total
includes taxes & fees
Oct 18 - Oct 19
Best Western Chula Vista/Otay Valley Hotel
An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,048 reviews)
"We love this hotel: all the staff are very nice and helpful."
United States
Shan Shan
The price is P12,170
P13,410 total
includes taxes & fees
Nov 2 - Nov 3
Ayres Hotel San Diego South - Chula Vista
An outdoor seating area with fire pit, lounge chairs, and tables, adjacent to a building with large windows and a brick facade.

5. Hampton Inn Chula Vista Eastlake

Hampton Inn Chula Vista Eastlake
2.5 star property
10.4 km from Otay Mesa
9.2 out of 10, Wonderful, (1,001 reviews)
"Rooms were nice and clean. Breakfast was very decent.. overall very pleased with the hotel"
United States
Daniel
The price is P10,770
P11,868 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Chula Vista Eastlake
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

6. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,593 reviews)
"Was a great stay!!"
United States
Taylor
The price is P11,069
P12,176 total
includes taxes & fees
Nov 5 - Nov 6
Holiday Inn Express San Diego South - Chula Vista by IHG
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

7. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,697 reviews)
"Great place. The location close to the ocean and the park was incredible"
United States
Carlos
The price is P6,490
P7,152 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn Chula Vista San Diego South
A hotel room with two beds, a wooden headboard, a bedside table with a phone, and a wall-mounted light fixture.

8. Rodeway Inn San Diego South San Ysidro Border

Rodeway Inn San Diego South San Ysidro Border
2.0 star property
5.8 km from Otay Mesa
7.8 out of 10, Good, (263 reviews)
"Great service beautiful hotel"
United States
Guadalupe
The price is P4,698
P5,344 total
includes taxes & fees
Oct 15 - Oct 16
Rodeway Inn San Diego South San Ysidro Border
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

9. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.8 out of 10, Excellent, (1,757 reviews)
"Enjoyed our stay"
United States
Nuwan
The price is P6,522
P7,174 total
includes taxes & fees
Nov 1 - Nov 2
La Quinta Inn by Wyndham San Diego Chula Vista
View from property

10. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (790 reviews)
"Clean room, great breakfast and pool, friendly and accommodating staff"
United States
Andren
The price is P12,386
P13,649 total
includes taxes & fees
Oct 25 - Oct 26
SpringHill Suites by Marriott Chula Vista Eastlake
A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.

11. Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,137 reviews)
"Nice place for a short stay"
United States
Aida
The price is P5,649
P6,437 total
includes taxes & fees
Oct 11 - Oct 12
Valli Hi Motel
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

12. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,181 reviews)
"Great property and we enjoyed the stay"
United States
Suresh
The price is P9,567
P10,542 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Plus Marina Gateway Hotel
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

13. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,394 reviews)
The price is P6,586
P7,492 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Americana Inn
A room with two teal armchairs, a small round table with a lamp, and a large cityscape painting on the wall.

14. SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay
3.0 star property
14.7 km from Otay Mesa
8.0 out of 10, Very good, (1,955 reviews)
"Clean room, great breakfast, nice staff. I would stay here again"
United States
Frances
The price is P4,802
P5,292 total
includes taxes & fees
Oct 18 - Oct 19
SureStay Hotel by Best Western Chula Vista San Diego Bay
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

15. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,553 reviews)
"Clean room and great staff"
United States
Francisco
The price is P5,523
P6,086 total
includes taxes & fees
Oct 18 - Oct 19
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

16. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,213 reviews)
The price is P7,469
P8,641 total
includes taxes & fees
Oct 19 - Oct 20
The Rambler Hotel
A swimming pool with palm trees and a mountain in the background.

17. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,174 reviews)
"Loved the stay for my birthday!"
United States
Alexza
The price is P6,201
P7,576 total
includes taxes & fees
Oct 15 - Oct 16
Sycuan Casino Resort
A hotel room with a bed, a desk, a kitchenette, and a bathroom.

18. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,376 reviews)
"Nice rooms , clean staff was nice"
United States
Wendy
The price is P4,549
P5,004 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Palmeras Chula Vista
A hotel room with two beds, a desk, and a chair.

19. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,155 reviews)
"Very clean and friendly would stay here again"
Canada
Michelle
The price is P5,084
P5,602 total
includes taxes & fees
Oct 18 - Oct 19
Howard Johnson by Wyndham National City/San Diego South
A spacious indoor area with wooden tables and chairs, a high ceiling with wooden beams, and a view of the outside through large windows.

20. Holiday Inn Express & Suites San Diego - Mission Valley by IHG

Holiday Inn Express & Suites San Diego - Mission Valley by IHG
2.5 star property
28.8 km from Otay Mesa
8.8 out of 10, Excellent, (1,012 reviews)
The price is P9,371
P11,006 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express & Suites San Diego - Mission Valley by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Hotels recommended for families in Otay Mesa

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,917)
The price is P8,176
P9,300 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa Hotel Reviews

The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"Got a vip room upgrade to 3rd floor bay view which is always nice. Great pool and hot tub staff and bartenders are excellent!"
Scott 2-night trip
Posted 5 hours ago
The Dana on Mission Bay

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.