
Otay Mesa Hotels near San Diego
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2. Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
3. Best Western Americana Inn
Best Western Americana Inn
4. Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista
5. Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel
6. Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South
7. La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista
8. Holiday Inn Express San Diego South - Chula Vista by IHG
Holiday Inn Express San Diego South - Chula Vista by IHG
9. SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake
10. SureStay Hotel by Best Western Chula Vista San Diego Bay
SureStay Hotel by Best Western Chula Vista San Diego Bay
11. The Rambler Hotel
The Rambler Hotel
12. Hercor Hotel - Urban Boutique
Hercor Hotel - Urban Boutique
13. Hotel Palmeras Chula Vista
Hotel Palmeras Chula Vista
14. Motel 6 El Cajon, CA - San Diego
Motel 6 El Cajon, CA - San Diego
15. Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station
16. Best Western Yacht Harbor Hotel
Best Western Yacht Harbor Hotel
17. Sheraton San Diego Resort
Sheraton San Diego Resort
18. Lamplighter Inn & Suites at SDSU
Lamplighter Inn & Suites at SDSU
19. Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG
20. Embassy Suites by Hilton San Diego Bay Downtown
Embassy Suites by Hilton San Diego Bay DowntownWhere to stay in Otay Mesa

Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.




















































































