Otay Mesa Trips (flight + hotel)

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area

Petco Park and USS Midway Museum are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Find hotel + flight trips in Downtown San Diego

Top hotels in Otay Mesa

Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is P6,847 per night from 5 May to 6 May
P6,847
per night
5 May - 6 May
7/10 Good! (2,597 reviews)
"Was nicer than the one in Oceanside we stayed at. However, I was surprised that we had to pay to park our car at the hotel. That seems a little extreme. Staff was pompous and condescending. Not smiling or happy. Would have rather of continued their conversation that we interrupted by arriving. But ..."

Reviewed on May 2, 2024

Wyndham Garden San Diego Near SeaWorld
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is P9,243 per night from 23 May to 24 May
P9,243
per night
23 May - 24 May
8/10 Very Good! (5,929 reviews)
Location Location Location
"Great location. Older building with a lot of character. The room was a bit dated."

Reviewed on May 3, 2024

Wyndham San Diego Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is P10,299 per night from 6 May to 7 May
P10,299
per night
6 May - 7 May
8.6/10 Excellent! (2,400 reviews)
"The property was a little loud. But it was clean and easily accessible. While I prefer a hotel to a motel, this was good"

Reviewed on May 2, 2024

The Dana on Mission Bay
See all 4,495 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as , a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you’ll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there’s a package that’s perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn’t be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It’s one of this neighborhood’s most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That’s alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you’re traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you’ll land terrific discounts. Whether you’re organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don’t worry if you’re rethinking your Otay Mesa vacation package — it’s possible to change or amend your booking. And if you’ve booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you’re ready to make changes, we’re ready to help.

Popular places to visit

Image for San Diego Zoo

San Diego Zoo

One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

San Diego Zoo
Image for SeaWorld

SeaWorld

A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.

SeaWorld
Image for Mission Bay

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

Image for Tijuana Local Walking Tour from San Diego

Tijuana Local Walking Tour from San Diego

P2,932
Per adult
100% of travellers recommend
Tijuana Local Walking Tour from San Diego
Image for Sesame Place® San Diego

Sesame Place® San Diego

P2,689
Per adult
86% of travellers recommend
Sesame Place® San Diego
Image for Tijuana & Rosarito tour/the best tacos el yaqui

Tijuana & Rosarito tour/the best tacos el yaqui

P3,320
Per adult
Tijuana & Rosarito tour/the best tacos el yaqui
See all activities in San Diego

More trip options

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.