Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's acclaimed art scene and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Top hotels in Otay Mesa
Hilton San Diego Mission Valley
Room was spotless, nice room. Good area
Reviewed on Nov 15, 2025
Legacy Resort Hotel & Spa
Nice
Reviewed on Nov 10, 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Very clean. Very nice hotel. Enjoyed the breakfast. The breakfast was a hit with the kids
Reviewed on Nov 11, 2025
Hard Rock Hotel San Diego
We did not experience breakfast but everything else about the hotel was fantastic. The staff was extremely friendly and helpful. You can walk to all the restaurants and lounges.
Reviewed on Nov 14, 2025
Pendry San Diego
Beautiful hotel. Beat all expectations
Reviewed on Nov 12, 2025
Courtyard by Marriott San Diego Downtown Little Italy
Great stay and centrally located yet away from heavy foot taffic. Older building so parking structure is tight. Well appointed. Restaurant and bar is amazing. Must try. Friendly staff.
Reviewed on Nov 9, 2025
Other neighbourhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa
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