Otay Mesa

San Diego


Popular places to visit

Things to do


Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
The price is P8,085 per night from Aug 10 to Aug 11
P8,085
P9,196 total
Aug 10 - Aug 11
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,406 reviews)
"I really like this hotel. Breakfast was good and had a lot of options and the rooms were spacious. I really liked that."

Reviewed on Jul 28, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,911 reviews)
"Over Really Great experience. Only complaint waa the bed was a wasn't the best and Pillows were Uncomfortable for me personally. Pool was fantastic loved the night right"

Reviewed on Jul 31, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is P8,850 per night from Sep 1 to Sep 2
P8,850
P11,930 total
Sep 1 - Sep 2
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,770 reviews)
"Hotel room was excellent. Service for checking in was slow because of low staff. Requested bell cart which took so long i left."

Reviewed on Aug 1, 2025

Wyndham San Diego Bayside
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4 out of 5
601 Pacific Hwy, San Diego, CA
The price is P10,333 per night from Aug 17 to Aug 18
P10,333
P13,600 total
Aug 17 - Aug 18
includes taxes & fees
Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,320 reviews)
"The hotel is really good but there are lots of surcharges that makes me decide not to go back in this hotel. Embassy Suite is always nice, but this branch is the least on my lists."

Reviewed on Jul 30, 2025

Embassy Suites by Hilton San Diego Bay Downtown
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is P10,993 per night from Aug 31 to Sep 1
P10,993
P15,910 total
Aug 31 - Sep 1
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,781 reviews)
Great hotel, friendly staff
"Our room had a great view of the seaport. Room and bathroom were quite clean. Staff were very pleasant and accommodating. Hotel had overall friendly atmosphere. Location was close to the SDCC. Will surely book here again when we come back to San Diego."

Reviewed on Aug 3, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is P9,632 per night from Aug 17 to Aug 18
P9,632
P11,071 total
Aug 17 - Aug 18
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,596 reviews)
"The restaurant service was extremely slow"

Reviewed on Aug 1, 2025

The Dana on Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

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Mid-City

If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter which includes signage, a bar and night scenes

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

Gaslamp Quarter
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Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Downtown San Diego
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North Park

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
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Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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Del Cerro

Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.

Del Cerro

Otay Mesa