Otay Mesa

San Diego


Popular places to visit

Things to do


Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
The price is P7,477 per night from Aug 23 to Aug 24
P7,477
P8,505 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,424 reviews)
"Staff"

Reviewed on Aug 13, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
The price is P9,709 per night from Aug 31 to Sep 1
P9,709
P14,362 total
Aug 31 - Sep 1
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,782 reviews)
"Lots of hidden fees"

Reviewed on Aug 13, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is P9,646 per night from Aug 24 to Aug 25
P9,646
P11,088 total
Aug 24 - Aug 25
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,634 reviews)
Nice hotel with ok accommodations/service
"I enjoyed my time at the Dana, I have stayed here in the past as well. The restaurant onsite had good food and good service. It’s a great location for walking. The staff was friendly and accommodating however I did have tiny ants in my room. Staff were prompt to fix the issue and throughly cleaned ..."

Reviewed on Aug 16, 2025

The Dana on Mission Bay
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is P8,684 per night from Sep 3 to Sep 4
P8,684
P11,479 total
Sep 3 - Sep 4
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,844 reviews)
"We loved the location and views from the balcony. Very much in the hub of things. We were disappointed with the property's lack of updates. The bathroom was very outdated. Cleanliness was good. Just feel for the price and comparable in the area, this hotel could use some updating. We will stay again ..."

Reviewed on Aug 15, 2025

Wyndham San Diego Bayside
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
The price is P9,555 per night from Sep 1 to Sep 2
P9,555
P13,799 total
Sep 1 - Sep 2
includes taxes & fees
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,502 reviews)
"Everything was excellent — a truly family-friendly hotel with outstanding customer service. The breakfast was delicious and offered a great variety. The hotel also has a fun play area for the kids, and the pool was clean, relaxing, and perfect for all ages."

Reviewed on Aug 14, 2025

Hyatt Regency Mission Bay Spa and Marina
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,959 reviews)
"A little noisy but bareable."

Reviewed on Aug 13, 2025

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Petco Park featuring a statue or sculpture

East Village

Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
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Mid-City

If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter which includes signage, a bar and night scenes

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

Gaslamp Quarter
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Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Downtown San Diego
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North Park

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
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Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy

Otay Mesa