Otay Mesa

San Diego

Tijuana Neighborhood Seen Over Border Fence
Tijuana Neighborhood Seen Over Border Fence

Popular places to visit

Things to do


Top hotels in Otay Mesa

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is P13,176 per night from Mar 11 to Mar 12
P13,176
P18,268 total
Mar 11 - Mar 12
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,450 reviews)
I was expecting so much more from a 4 star resort. This place is 2 stars at BEST. It is very reminiscent of camping. It is very isolated and it feels like it is tucked away in the woods. We kept finding little bugs everywhere. Especially behind the curtains there were upwards of 100s of bugs. The ...

Reviewed on Mar 8, 2026

Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
The price is P4,295 per night from Mar 22 to Mar 23
P4,295
P4,937 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,277 reviews)
Room had an old musky odor, property is in need of remodeling. First BW that didn't have a coffee machine in rooms or complementary on the lobby. Had to go in the cafe and pay $4.75 for a cup of coffee. There was no complementary breakfast.

Reviewed on Mar 8, 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is P13,223 per night from Mar 11 to Mar 12
P13,223
P18,174 total
Mar 11 - Mar 12
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,395 reviews)
Room was great!

Reviewed on Mar 9, 2026

Hard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
The price is P6,952 per night from Mar 10 to Mar 11
P6,952
P8,060 total
Mar 10 - Mar 11
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9/10 Wonderful! (1,166 reviews)
Overall, I was quite pleased. Didn’t have a continental/free breakfast though

Reviewed on Mar 8, 2026

The DEXTRO Little Italy, BW Premier Collection
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
The price is P5,523 per night from Mar 11 to Mar 12
P5,523
P6,348 total
Mar 11 - Mar 12
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (2,540 reviews)
Room carpet smelled like urine, stairwells dirty, pool dirty, requested clean towels 3 times they were never delivered. Worst hotel I’ve ever stayed at. This hotel did not feel clean or safe.

Reviewed on Mar 8, 2026

Days Inn by Wyndham San Diego Hotel Circle
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
The price is P6,971 per night from Apr 1 to Apr 2
P6,971
P8,013 total
Apr 1 - Apr 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (2,340 reviews)
Bathrooms were dirty. U don’t like carp d rooms. And they had no water bottle in the rooms for guest. The vending machines in my wing were out of drinks in general. I was not impressed.

Reviewed on Mar 6, 2026

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Petco Park featuring a statue or sculpture

East Village

Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
Gaslamp Quarter which includes signage, a bar and night scenes

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Harlem of the West Sites is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

Gaslamp Quarter
US Grant Hotel

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

Downtown San Diego
SanDiego_NorthPark_6346499_001

North Park

North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.

North Park
Little Italy

Little Italy

Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.

Little Italy
Gossip Grill

Hillcrest

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest


Otay Mesa