Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
One of America’s largest urban green spaces, Balboa Park is an exciting spot packed with art, culture, and a world-renowned zoo.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Top hotels in Otay Mesa
Hard Rock Hotel San Diego
Great
Reviewed on Jan 13, 2026
Sheraton San Diego Resort
Very nice room
Reviewed on Jan 13, 2026
Courtyard by Marriott San Diego Downtown Little Italy
Overall, we had a comfortable stay. The hotel itself was clean and well maintained. The check-out staff member was especially helpful and friendly, which we truly appreciated. The bar’s food selection was limited, but the staff member went out of her way to help us find something we could enjoy, ...
Reviewed on Jan 15, 2026
The Dana on Mission Bay
Good service! Staff were very friendly and accommodating.
Reviewed on Jan 14, 2026
Pendry San Diego
The room was clean, tasteful, and quiet. The staff was very friendly and helpful. We had a wonderful time in Pendry.
Reviewed on Jan 1, 2026
The DEXTRO Little Italy, BW Premier Collection
Paid parking, if you have truck / big SUV there are not enough space. Hotel, view, location are great.
Reviewed on Jan 13, 2026
Other neighbourhoods around Otay Mesa
East Village
Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Lyceum Theatre is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and New Children's Museum, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
