Santa Ana
Panama City
Visit Santa Ana
Stay near popular Santa Ana attractions
Things to do
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
P6,177
per adult
94% of travellers recommend
From Panama City: San Blas Island Hopping Day Tour
P9,047
per adult
98% of travellers recommend
Half day of Panama city and canal tour: shared and private
P4,168
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
P2,876
per adult
96% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
P3,001
per adult
98% of travellers recommend
Top hotels in Santa Ana
Hotel Caracas - Casco Viejo
Plaza De Santa Ana Panama City Provincia di Panama
The price is P2,413 per night from Oct 20 to Oct 21
P2,413
P2,654 total
Oct 20 - Oct 21
includes taxes & fees
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...
8/10 Very Good! (19 reviews)
"Good location but basic otherwise. Staff not overly helpful on the whole."
Reviewed on Sep 27, 2026
Casco View Life Residences
C. 16 Oeste Panama City Provincia de Panamá
The price is P4,952 per night from Oct 12 to Oct 13
P4,952
P7,326 total
Oct 12 - Oct 13
includes taxes & fees
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
9/10 Wonderful! (108 reviews)
"It is a new place, an apartment was in pristine condition. The building is 2 blocks away from the old town."
Reviewed on Oct 6, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
The price is P8,283 per night from Oct 21 to Oct 22
P8,283
P9,112 total
Oct 21 - Oct 22
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (6,034 reviews)
"Over all stay was amazing ‼️‼️ very clean areas and very helpful staff . Breakfast had so many varieties and tasted fresh and delicious. I will definitely be returning ."
Reviewed on Oct 7, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
The price is P6,708 per night from Oct 20 to Oct 21
P6,708
P7,379 total
Oct 20 - Oct 21
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,004 reviews)
"Awful!"
Reviewed on Oct 6, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
The price is P8,412 per night from Nov 6 to Nov 7
P8,412
P9,668 total
Nov 6 - Nov 7
includes taxes & fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (2,754 reviews)
"Great stay and very accommodating staff"
Reviewed on Oct 6, 2026
Megapolis Hotel Panamá
Avenida Balboa Panama City
The price is P8,720 per night from Oct 21 to Oct 22
P8,720
P8,720 total
Oct 21 - Oct 22
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (1,770 reviews)
"My stay at Megapolis was good overall. I booked two rooms, which felt a bit outdated, and one had an unpleasant mouldy smell. After housekeeping cleaned one room, it was left without towels or water. I requested both from the front desk and a cleaner nearby, but only the towels were brought back; ..."
Reviewed on Oct 7, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Photo by Fabiola Tile
Open Photo by Fabiola Tile
Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
