Santa Ana Trips (flight + hotel)

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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
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Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
The price is P5,217 per night from Sep 1 to Sep 2
P5,217
P5,738 total
Sep 1 - Sep 2
includes taxes & fees
9.2/10 Wonderful! (42 reviews)
"Very helpful and offered great suggestions. Cant wait to return!"

Reviewed on Jul 12, 2025

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
The price is P6,777 per night from Aug 11 to Aug 12
P6,777
P7,455 total
Aug 11 - Aug 12
includes taxes & fees
9/10 Wonderful! (4,140 reviews)
"Muy conveniente y agradable, excelente desayuno e instalaciones, excelente ubicación y personal de primera"

Reviewed on Aug 1, 2025

Hotel Riu Plaza Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is P7,693 per night from Aug 31 to Sep 1
P7,693
P8,462 total
Aug 31 - Sep 1
includes taxes & fees
8.4/10 Very Good! (914 reviews)
"Me and my husband loved staying there! Superb hotel beyond international standards! The staff was so friendly and attentive. The hotel is gorgeous! The pool is amazing and so is the spa. The breakfast buffet is excellent. I only have the best words to describe this place! I hope to stay there when ..."

Reviewed on Jul 26, 2025

Sheraton Grand Panama
See all 1,504 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as . Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Fuerte Amador Resort & Marina

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Check out the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,448
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
The Panama Barcrawl - The OG Crawl

The Panama Barcrawl - The OG Crawl

P3,685
per adult
96% of travellers recommend
The Panama Barcrawl - The OG Crawl
Bridge of the Americas

Private or Small Group Panama Canal & City Half-Day Tour

P3,799
per adult
Private or Small Group Panama Canal & City Half-Day Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.