Santa Ana
Panama City
Visit Santa Ana
Stay near popular Santa Ana attractions
Things to do
Half day of Panama city and canal tour: shared and private
P4,102
per adult
98% of travellers recommend
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City
P6,092
per adult
94% of travellers recommend
Panama City: POIN Swing Experience
P1,975
per adult
100% of travellers recommend
Visit San Blas Paradise: Day Tour to 4 Islands with Lunch & Drink
P5,107
per adult
88% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
P1,975
per adult
100% of travellers recommend
Top hotels in Santa Ana
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
The price is P4,114 per night from Aug 13 to Aug 14
P4,114
P6,355 total
Aug 13 - Aug 14
includes taxes & fees
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
9/10 Wonderful! (103 reviews)
"Amazing location and comfort"
Reviewed on Aug 8, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
The price is P8,043 per night from Sep 1 to Sep 2
P8,043
P8,847 total
Sep 1 - Sep 2
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (5,815 reviews)
"The breakfast was fantastic! Great service and overall hotel very well maintained. Staff was always available for any of our needs."
Reviewed on Aug 10, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
The price is P8,229 per night from Sep 6 to Sep 7
P8,229
P9,454 total
Sep 6 - Sep 7
includes taxes & fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (2,657 reviews)
"This property is convenient to the airport. The hotel is very clean and well maintained, the staff is very friendly and helpful, and the restaurant was excellent. Five stars!"
Reviewed on Aug 9, 2026
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo Panama City Panama
The price is P11,179 per night from Sep 9 to Sep 10
P11,179
P12,297 total
Sep 9 - Sep 10
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
The price is P16,595 per night from Aug 23 to Aug 24
P16,595
P16,595 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.6/10 Good! (1,056 reviews)
"Excelente, volvería mil veces"
Reviewed on Aug 10, 2026
Megapolis Hotel Panamá
Avenida Balboa Panama City
The price is P11,952 per night from Aug 28 to Aug 29
P11,952
P13,147 total
Aug 28 - Aug 29
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Photo by My World
Open Photo by My World
Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Luxor Towers might round out your trip.
San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
Punta Paitilla
Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.
