Santa Ana

Panama City

Photo by Isa
Photo by Isa

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Avenida Balboa

Avenida Balboa

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
Panama

Miraflores Locks

Learn about the local history of Ancon with a stop at Miraflores Locks. Visit the shops and casinos in this vibrant area.

Miraflores Locks
Fuerte Amador Resort & Marina

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Check out the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina
Calle 50

Calle 50

You can find out about the history of Panama City with a trip to Calle 50. Discover the area's shops, or seek out its local tours.

Calle 50

Things to do

Slingshot Tour Panama

Slingshot Tour Panama

P6,612
per adult
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,448
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

P1,820
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Panama: Visit an Indian village Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

P2,835
per adult
94% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City Tour and Panama Canal – Miraflores Locks Experience

Panama City Tour and Panama Canal – Miraflores Locks Experience

P1,984
per adult
100% of travellers recommend
Panama City Tour and Panama Canal – Miraflores Locks Experience
The Panama Barcrawl - The OG Crawl

The Panama Barcrawl - The OG Crawl

P3,685
per adult
96% of travellers recommend
The Panama Barcrawl - The OG Crawl
See all activities in Panama City

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
Stay at this 3-star condo in Panama City. Enjoy free WiFi, premium bedding, and in-room washers/dryers. Popular attractions Albrook Shopping Mall and Cinta Costera ...
9.2/10 Wonderful! (41 reviews)
"Very helpful and offered great suggestions. Cant wait to return!"

Reviewed on Jul 12, 2025

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Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
The price is P6,321 per night from Aug 20 to Aug 21
P6,321
P6,953 total
Aug 20 - Aug 21
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,119 reviews)
"Best breakfast I have ever had at a hotel. Hands down. So many options. The hotel is very lovely, spacious and comfortable. Only thing that bothered me is you could hear people walking or running above you at night. Hotel is very busy and guests are loud sometimes if you’re a light sleeper like me. ..."

Reviewed on Jul 22, 2025

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
The price is P9,385 per night from Aug 17 to Aug 18
P9,385
P9,385 total
Aug 17 - Aug 18
includes taxes & fees
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.2/10 Good! (1,016 reviews)
"It is a nice resort for all type customers adults only or with family. located by the ocean , great scenery, very kind and nice staffs with good service ,away from the city with clean air quality."

Reviewed on Jul 24, 2025

Dreams Playa Bonita Panama - All Inclusive
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is P7,089 per night from Aug 10 to Aug 11
P7,089
P7,798 total
Aug 10 - Aug 11
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (905 reviews)
"Food was good but not excellent ,bedrooms clean but in the tired side"

Reviewed on Jul 19, 2025

Sheraton Grand Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
The price is P6,800 per night from Aug 9 to Aug 10
P6,800
P7,480 total
Aug 9 - Aug 10
includes taxes & fees
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (2,167 reviews)
"Was great."

Reviewed on Jul 24, 2025

Crowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
The price is P4,539 per night from Jul 27 to Jul 28
P4,539
P4,993 total
Jul 27 - Jul 28
includes taxes & fees
Stay at this 4-star spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
9/10 Wonderful! (362 reviews)
"The property itself was nice, but I just had a few things that annoyed me. As soon as we got there, the television wasn't working. They got someone up there to check it, but he left saying he would return. He never did. The next day I stopped at the desk on my way out and told them. When I returned, ..."

Reviewed on Jul 23, 2025

Waymore Hotel Spa & Casino
See all 1,466 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Santa Ana

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Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Casco Viejo
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San Felipe

If you're spending some time in San Felipe, Metropolitan Cathedral of Panama and Interoceanic Canal Museum are top sights worth seeing.

San Felipe
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El Chorrillo

While there might not be top attractions in El Chorrillo, you can explore the larger area and discover places like Albrook Shopping Mall and Metropolitan Cathedral of Panama.

El Chorrillo
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Curundu

While Curundu isn't home to many top sights, Albrook Shopping Mall and Iglesia del Carmen are some notable places to visit nearby.

Curundu
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Calidonia

You might enjoy the shopping while in Calidonia. Cinta Costera is a notable sight, and you can get around town at Estación Lotería or Santo Tomas Station to see more of the city.

Calidonia
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Balboa

The restaurants and shopping are a few reasons travelers visit Balboa. Though there aren't many top sights in the neighborhood, you can visit Albrook Shopping Mall and Bridge of the Americas, a few notable attractions nearby.

Balboa

Santa Ana