Photo by PhotoJoy

Luxury Hotels in Panama

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Luxury Hotels

This weekend
Next weekend

Our top choices for Panama luxury hotels

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1002)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is P18,178
P19,995 total
includes taxes & fees
Jan 3 - Jan 4, 2026
JW Marriott Panama

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is P11,782
P12,960 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Bristol Panama, a Registry Collection Hotel

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1000)
"I loved everything about my stay "
United States
Stephanie
The price is P12,955
P14,251 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Waldorf Astoria Panama

American Trade Hotel

American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (607)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
The price is P17,126
P18,839 total
includes taxes & fees
Jan 4 - Jan 5, 2026
American Trade Hotel

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Everything was clean and the staff was very cooperative."
United States
Deangelo
The price is P9,338
P10,272 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1000)
"Nice room! Clean. Nice balcony, "
United States
Cassandra
The price is P11,833
P13,017 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hilton Panama

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very Good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
5.0 star property
El Chiru
9.2 out of 10, Wonderful, (689)
"Great place for a short stay "
United States
jeffrey
The price is P14,883
P16,372 total
includes taxes & fees
Jan 25 - Jan 26, 2026
The Buenaventura Golf & Beach Resort Panama, Autograph Collection

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1010)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is P9,217
P10,139 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Las Americas Golden Tower Panama

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1001)
"Great hotel and staff!"
United States
Catherine
The price is P9,456
P10,401 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Marriott Panama Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Panama Hotel Reviews

Explore a world of travel with Expedia