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Top destinations in Panama

Panama City

El Valle de Anton
Panama Vacation
While Panama is perhaps best known for its mighty canal, there’s so much more to this Central American country. Visitors will also be wowed by lush rainforests, idyllic beaches, rich indigenous culture and a unique colonial history.
Panama Hotel + Flights
Expedia has 3,280 hotels available here starting at P4,596 a night. But if you want to save some serious money, combine your hotel and flights into a Panama Vacation Package. You can also add car rental and activities to your booking to create an unforgettable getaway. With the dollars you save, why not book a tour and visit island paradises or taste famous local flavors like ceviche?
Your Panama Vacation Itinerary
Day 1-2: Start your adventure in the national capital, Panama City, and head straight to Casco Viejo (the Old Quarter). Wander narrow cobblestone streets and discover colorful Spanish colonial houses, beautiful churches and an impressive gastronomic scene. Plan a day trip to the Panama Canal to watch mammoth ships slip through the Miraflores Locks.
Day 3-5: Stay on some of the world’s most spectacular islands in San Blas. Owned and operated by the Kuna people, this untouched paradise on the Caribbean side of Panama is the perfect place to live out your Robinson Crusoe fantasies.
Day 6-8: Head back to Panama City and fly to the mountain town of Boquete. A top destination for outdoor lovers, it offers jungle hikes, whitewater rafting, canopy tours, zip lining and more.
Panama Information
Party with the locals at Carnival, Panama’s largest annual celebration. You’ll find the biggest events in Panama City and Las Tablas.
If you’ll be spending most of your time in the nation’s capital, check out our Panama City Vacation PackagesOpens in a new window.
Want to really experience the carefree vibe of this Latin American gem? Book one of our Panama All Inclusive Resorts and say adios to vacation planning stress.
Top hotels in Panama

Hotel Riu Plaza Panama
Reviewed on Aug 13, 2025

Sheraton Grand Panama
Reviewed on Aug 6, 2025

Waymore Hotel Spa & Casino
Reviewed on Aug 11, 2025
Frequently asked questions
Popular places to visit

Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Cinta Costera
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Fuerte Amador Resort & Marina
Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Check out the shops and top-notch restaurants in this vibrant area.
What to do in Panama

Day Tour in San Blas Islands All Included Visiting 4 Islands

Panama City: Poin Glass Observation Deck Ticket with VR Tour
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