Santa Cruz Hotels

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Check prices for these dates

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

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Our top choices for Santa Cruz hotels

Front of property
Hotel El Zarzo

Hotel El Zarzo

Hotel El Zarzo
4.0 star property
El Poblado
9.6 out of 10, Exceptional, (251)
"Great hotel and location. Amazing staff and very clean. "
United States
Jeremy
The price is P11,782
P11,782 total
Jan 27 - Jan 28, 2026
Hotel El Zarzo
Front of property
HOTEL SELIS

HOTEL SELIS

HOTEL SELIS
3.5 star property
El Poblado
9.6 out of 10, Exceptional, (295)
"Clean room nice staff"
United States
Arlene
The price is P4,809
P4,809 total
Jan 5 - Jan 6, 2026
HOTEL SELIS
Restaurant
23Hotel Medellin

23Hotel Medellin

23Hotel Medellin
3.5 star property
El Poblado
9.4 out of 10, Exceptional, (346)
"Great place "
Mexico
David
23Hotel Medellin
Restaurant
The Click Clack Hotel Medellin

The Click Clack Hotel Medellin

The Click Clack Hotel Medellin
5.0 star property
El Poblado
9.2 out of 10, Wonderful, (1075)
"Great hotel."
United States
Luz Alma
The price is P12,282
P12,282 total
Jan 20 - Jan 21, 2026
The Click Clack Hotel Medellin
Terrace/patio
The Somos Bold Hotel

The Somos Bold Hotel

The Somos Bold Hotel
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (228)
"WAS PERFECT!"
Canada
Irina
The price is P5,913
P5,913 total
Jan 14 - Jan 15, 2026
The Somos Bold Hotel
Alfresco dining
Selvario 36 Hotel

Selvario 36 Hotel

Selvario 36 Hotel
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (590)
"We really loved the FOOD and drinks at the hotel. The staff was friendly and fully bilingual. They were helpful in telling us great places to visit nearby and I felt extremely safe during my stay."
United States
Tonya
The price is P13,412
P13,412 total
Jan 8 - Jan 9, 2026
Selvario 36 Hotel
Reception
The Host Medellin Only Adults

The Host Medellin Only Adults

The Host Medellin Only Adults
3.0 star property
El Poblado
9.8 out of 10, Exceptional, (13)
"Great ambience and room, excellent breakfast "
United States
Shailendra
The price is P13,840
P13,840 total
Jan 7 - Jan 8, 2026
The Host Medellin Only Adults
32-inch TV with cable channels
The Art Hotel Medellin

The Art Hotel Medellin

The Art Hotel Medellin
3.5 star property
El Poblado
7.8 out of 10, Good, (1000)
"The staff was great! It was really close to everything in El Poblado. The restaurant was really good too. Definitely recommend!"
United States
Miguel Jose Sanchez
The price is P4,944
P4,944 total
Dec 30 - Dec 31
The Art Hotel Medellin
Property grounds
ANTÍPODA HOTEL

ANTÍPODA HOTEL

ANTÍPODA HOTEL
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (180)
"Great location clean room and great staff. A bit noisy though"
Canada
Yuting
The price is P3,213
P4,006 total
Dec 29 - Dec 30
ANTÍPODA HOTEL
Free daily buffet breakfast
Hotel Du Parc

Hotel Du Parc

Hotel Du Parc
4.5 star property
El Poblado
9.4 out of 10, Exceptional, (1004)
"Great hotel. Excellent and friendly staff. Breakfast is fantastic. Great location. "
United States
Steven
The price is P10,575
P10,575 total
Jan 13 - Jan 14, 2026
Hotel Du Parc
Arcade
Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (1006)
"This hotel is so good , stay here when I go to Medellin "
United States
Luis
The price is P6,888
P6,888 total
Jan 11 - Jan 12, 2026
Diez Hotel Categoria Colombia
Hypo-allergenic bedding, down comforters, pillowtop beds, minibar
The Somos Beats Hotel & Rooftop

The Somos Beats Hotel & Rooftop

The Somos Beats Hotel & Rooftop
3.5 star property
El Poblado
8.4 out of 10, Very Good, (348)
"Great stay no complaints at all "
United States
Casey
The price is P4,870
P4,870 total
Jan 4 - Jan 5, 2026
The Somos Beats Hotel & Rooftop
Indoor pool, outdoor pool, sun loungers
York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton
4.0 star property
El Poblado
9.6 out of 10, Exceptional, (1427)
"The rooms were clean, the view was stunning, and the staff were incredibly friendly and professional."
United States
RAMON
The price is P7,646
P7,646 total
Jan 27 - Jan 28, 2026
York Medellin, Curio Collection by Hilton
Reception
Moet Medellin Hotel

Moet Medellin Hotel

Moet Medellin Hotel
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (125)
"Very clean and friendly environment "
United States
Jennifer
Moet Medellin Hotel
Bar (on property)
Binn Hotel

Binn Hotel

Binn Hotel
4.5 star property
El Poblado
9.2 out of 10, Wonderful, (1004)
"Excellent hotel and staff! Rooftop restaurant and pool was amazing "
Canada
Sahar
The price is P11,865
P11,865 total
Jan 10 - Jan 11, 2026
Binn Hotel
Terrace/patio
Lettera Hotel

Lettera Hotel

Lettera Hotel
3.5 star property
El Poblado
9.8 out of 10, Exceptional, (456)
"Excellent hotel and staff "
United States
Jose
Lettera Hotel
Front of property
Hotel Lleras 10

Hotel Lleras 10

Hotel Lleras 10
3.0 star property
El Poblado
8.2 out of 10, Very Good, (334)
"Great hotel , staff is great "
United States
Luis
Hotel Lleras 10
Minibar, in-room safe, desk, blackout drapes
Hotel Lagoon

Hotel Lagoon

Hotel Lagoon
3.5 star property
Rionegro
9.2 out of 10, Wonderful, (301)
"Nice property, very good food, very relaxing."
United States
Kevin
The price is P7,983
P7,983 total
Jan 6 - Jan 7, 2026
Hotel Lagoon
Terrace/patio
Landmark Hotel

Landmark Hotel

Landmark Hotel
4.0 star property
El Poblado
9.6 out of 10, Exceptional, (232)
"Very nice hotel. "
United States
Andres F.
The price is P8,170
P8,170 total
Jan 13 - Jan 14, 2026
Landmark Hotel
Jetted tub
La Martina Boutique Hotel

La Martina Boutique Hotel

La Martina Boutique Hotel
3.5 star property
El Poblado
8.4 out of 10, Very Good, (290)
"Very nice hotel, will be staying here again when I come back to Medellín "
United States
Ryan
La Martina Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

York Luxury Suites Medellín

York Luxury Suites Medellín

10/10 Excellent
"The rooms were clean, the view was stunning, and the staff were incredibly friendly and professional."
RAMON 6-night trip
Posted 2 days ago
York Luxury Suites Medellín

More cheap stays in Santa Cruz

Hotel Villanueva Comfort

Hotel Villanueva Comfort

57-12 Cra. 49 Medellín Antioquia
The price is P2,098 per night from Dec 31 to Jan 1
P2,098
P2,098 total
Dec 31 - Jan 1, 2026
8.6/10 Excellent! (29 reviews)

Frequently asked questions

Where is the best place to stay in Santa Cruz?
Located 5.9 mi (9.4 km) from the heart of Santa Cruz, Heiss Hotel By Jalo is a top choice for your stay based on our traveler data. Other good choices for your trip to the area are Calle Flora Hotel by Jalo and York Medellin, Curio Collection by Hilton. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
La Gracia Hotel & Spa: This vacation home rental near Santa Cruz offers a terrace, a garden, and free WiFi to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What is staying in Santa Cruz like?
Visitors are sure to enjoy all that Santa Cruz has to offer. In Santa Cruz, there are 3 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What are the top places to visit in Santa Cruz?
Places to visit in the wider area include Medellin Botanical Garden, Explora Park, and Arvi Park. You'll also find Antioquia Museum and Botero Plaza in the area. Check out what more to see and do in Expedia's Santa Cruz guide.
How can I get around Santa Cruz?
Head over to Andalucía MetroCable Station for metro transit. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually August and July with an average temp of 66°F, while the coldest months are December and January with an average of 64°F. The rainiest months in Santa Cruz are May, April, October, and November, with each month seeing an average of 16 inches of rainfall.

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