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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Santa Cruz vacation rentals

A person relaxing in a hot tub with a scenic view of mountains and clouds.

1. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
The price is P3,553
P4,456 total
Oct 1 - Oct 2
Skyline Ecoliving
A rooftop patio with tables and chairs, a bar area, and a view of the cityscape.

2. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (25 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
The price is P3,571
P3,571 total
Sep 29 - Sep 30
B 48 Living by B Rent
A neatly made bed with a wooden headboard, a bedside table with a bottle and a glass, and a chair in a bright room with a large window.

3. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.0 out of 10, Wonderful, (295 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is P4,102
P4,102 total
Oct 2 - Oct 3
Portal del Rodeo ApartaHotel - Arkadia Mall
A modern hotel room with a large bed, a flat-screen TV, and a view of the city through large windows.

4. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (145 reviews)
"The staff were terrific and helpful. The room was perfect in an ideal location."
United States
Amy
The price is P4,349
P6,047 total
Sep 30 - Oct 1
Factory Lofts
A modern kitchen with an island, bar stools, and a dining area with a sofa and coffee table.

5. Luxury Suites Prana By Cadissa

Luxury Suites Prana By Cadissa
5.0 star property
Laureles - Estadio
9.4 out of 10, Exceptional, (57 reviews)
"The hotel is Nestled in the middle of many attractions. Whick is like a quick 15 minutes from most popular attractions. The rental is more like an apartment with a full kitchen and the rooms are air conditioned."
United States
Jimmy
The price is P4,877
P7,425 total
Oct 12 - Oct 13
Luxury Suites Prana By Cadissa
A modern apartment with a living area, kitchenette, and large windows offering city views.

6. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (177 reviews)
"Excellent place to stay."
United States
Rexford
The price is P3,343
P3,343 total
Oct 2 - Oct 3
Kyux by Jalo
A modern living room with a large window, a sofa set, a coffee table, and a potted plant.

7. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
8.8 out of 10, Excellent, (88 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is P2,710
P4,084 total
Sep 29 - Sep 30
Metropolitan Living by HOUSY
A modern interior with marble flooring, a reception area, and a seating area with tables and chairs.

8. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (735 reviews)
"When I travel to Medellin I always stay at Haven. Everything is always great!!!"
United States
Aaron
The price is P6,289
P6,289 total
Sep 29 - Sep 30
Haven, A Design Hotel
A modern bedroom with a large bed, a built-in wardrobe, a kitchen area, and a balcony with plants.

9. Living by Armoniko

Living by Armoniko
4.0 star property
Laureles
9.4 out of 10, Exceptional, (83 reviews)
"We liked the location and that they have parking on their property."
United States
Richard
The price is P7,162
P7,539 total
Sep 29 - Sep 30
Living by Armoniko
A bedroom with a bed, a bedside table with a plant, a sofa, and a wall with a large blue arch.

10. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.6 out of 10, Excellent, (4 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is P1,720
P1,720 total
Oct 9 - Oct 10
Hotel Moore 45
A hotel room with a large bed, a nightstand, a lamp, and a window with a city view.

11. VENTO MOLINO

VENTO MOLINO
3.0 star property
Belen
The price is P3,141
P3,141 total
Sep 29 - Sep 30
VENTO MOLINO
A modern bedroom with a bed, a wooden desk, and a chair.

12. The Somos Flats Laureles

The Somos Flats Laureles
4.0 star property
Laureles
9.0 out of 10, Wonderful, (67 reviews)
"Great property and very accommodating host."
United States
Joseph
The price is P3,881
P3,881 total
Oct 5 - Oct 6
The Somos Flats Laureles
A modern kitchen with a central island, wooden cabinets, and a view of a cityscape through large windows.

13. GRAND BY LINARES

GRAND BY LINARES
3.0 star property
El Poblado
10.0 out of 10, Exceptional, (6 reviews)
"Amazing host and property. 10/10"
United States
Manny
The price is P4,043
P5,930 total
Sep 29 - Sep 30
GRAND BY LINARES
A balcony with a hot tub, wooden steps, and a potted plant.

14. Wake Living

Wake Living
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (232 reviews)
"Great place"
United States
Pedro
The price is P9,800
P9,800 total
Sep 30 - Oct 1
Wake Living
A staircase with black railings and wooden steps, leading to a wooden wall.

15. zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (72 reviews)
"Room was perfect, if you’re staying for a long trip, I highly recommend getting the room with the washer. Super clean and amazing location."
United States
Kirman
The price is P1,856
P1,856 total
Sep 29 - Sep 30
zenia
An outdoor café with tables and chairs, surrounded by potted plants and a view of buildings.

16. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (104 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is P2,595
P2,595 total
Sep 29 - Sep 30
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
A balcony with a city view, a seating area with a sofa and chairs, and a modern interior design.

17. Feeling Residences

Feeling Residences
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (296 reviews)
"Great place to stay!"
United States
marcos
The price is P6,228
P6,228 total
Oct 6 - Oct 7
Feeling Residences
A modern hotel room with a bed, a desk, a TV, and a balcony with a view.

18. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (217 reviews)
"My favorite place to stay by far! Everything is within few blocks! Bars,discos, restaurants! You named!! The staff is like family to me ! I highly recommend this hotel!!"
United States
Luis
The price is P3,475
P3,475 total
Sep 29 - Sep 30
Origen Local Suites
A modern spa with a rectangular hot tub, three lit candles on a wooden tray, and a beige sofa in the background.

19. Devú

Devú
5.0 star property
El Poblado
9.8 out of 10, Exceptional, (40 reviews)
"Great rooms, location of the building is a little uncomfortable for walking or taking transport due to the high speed of the road right in front."
United States
Juan
The price is P9,720
P9,720 total
Oct 18 - Oct 19
Devú
A modern bathroom with a bathtub, a window with a city view, and a wooden ceiling.

20. The Arena House

The Arena House
4.5 star property
El Poblado
The price is P4,368
P6,821 total
Sep 29 - Sep 30
The Arena House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

8/10 Good
"Roof top, mal servicio"
Yadiel Antonio 5-night trip
Posted 2 hours ago
Hashtag 98 Hotel By Jalo

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.