Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Oct 10 - Oct 12
In two months
Nov 21 - Nov 23
In three months
Dec 19 - Dec 21
In four months
Jan 16 - Jan 18

Vacation Rentals in Santa Cruz

York Luxury Suites Medellín
Indoor pool, outdoor pool, sun loungers

York Luxury Suites Medellín

4.0 star property
9.6 out of 10, Exceptional, (1328)
"The staff were friendly, and the amenities were great—a great place to stay. "
York Luxury Suites Medellín
Sites Hotel
Rooftop pool

Sites Hotel

4.0 star property
9.2 out of 10, Wonderful, (1078)
"excellent service & comfortable suites"
The price is P4,876
P4,876 total
Oct 12 - Oct 13
Sites Hotel
Factory Lofts
1 bedroom, Egyptian cotton sheets, premium bedding, down comforters

Factory Lofts

4.0 star property
9.8 out of 10, Exceptional, (86)
"Wonderful place in a walkable area. "
The price is P2,905
P4,243 total
Sep 28 - Sep 29
Factory Lofts
Haven
Lobby

Haven

4.0 star property
8.8 out of 10, Excellent, (610)
"Todo excelente "
The price is P5,783
P5,783 total
Sep 29 - Sep 30
Haven
Royal Living Poblado
Terrace/patio

Royal Living Poblado

4.0 star property
9.2 out of 10, Wonderful, (43)
"Great place"
Royal Living Poblado
Botánica Manila by HOUSY HOST
Television

Botánica Manila by HOUSY HOST

3.0 star property
9.0 out of 10, Wonderful, (37)
"Staff was nice, property was pretty clean, even had a kitchen and refrigerator. Area around the property is nice FOR THE AREA. "
Botánica Manila by HOUSY HOST
Estelar Apartamentos Medellin
7 bedrooms, premium bedding, memory foam beds, in-room safe

Estelar Apartamentos Medellin

3.5 star property
8.8 out of 10, Excellent, (444)
"Is a perfect hitel as it's close to one of the most popular malls which is Santa Fé and is easy accessible "
The price is P5,230
P5,230 total
Oct 25 - Oct 26
Estelar Apartamentos Medellin
Kyux by Jalo
Living area

Kyux by Jalo

4.0 star property
9.6 out of 10, Exceptional, (28)
"Great place"
Kyux by Jalo
zenia
Staircase

zenia

3.0 star property
9.2 out of 10, Wonderful, (30)
"Seamless and excellent communication, will book again if I am in the area. "
The price is P1,265
P1,265 total
Sep 29 - Sep 30
zenia
Wake Living
Living area

Wake Living

4.0 star property
8.8 out of 10, Excellent, (152)
"Amazing Property would stay again "
The price is P8,436
P8,436 total
Sep 29 - Sep 30
Wake Living
Apartment Go Living & Suites by HOUSY HOST
Coffee shop

Apartment Go Living & Suites by HOUSY HOST

3.5 star property
8.4 out of 10, Very Good, (375)
"Great stay!! I always stay here when I visit Medellin "
Apartment Go Living & Suites by HOUSY HOST
Origen Local Suites
Street view

Origen Local Suites

3.0 star property
9.4 out of 10, Exceptional, (174)
"Good location I always stay at this hotel no complain highly recommended 👍"
The price is P3,115
P3,115 total
Sep 29 - Sep 30
Origen Local Suites
Seissta Medellin
Restaurant

Seissta Medellin

4.0 star property
9.2 out of 10, Wonderful, (195)
"best stay i’ve ever had in my life. love this hotel and the staff"
The price is P6,289
P6,289 total
Oct 6 - Oct 7
Seissta Medellin
Quadrato Studios
Outdoor spa tub

Quadrato Studios

3.0 star property
9.4 out of 10, Exceptional, (58)
"This place was amazing Great staff"
Quadrato Studios
Alcázar de Oviedo By EE Hotels
Living area

Alcázar de Oviedo By EE Hotels

3.0 star property
9.4 out of 10, Exceptional, (156)
"I had a great time at the hotel. The rooms were comfortable, and the staff were very kind, thanks to Juliana and Daisy especially for their attention"
The price is P5,338
P5,338 total
Sep 27 - Sep 28
Alcázar de Oviedo By EE Hotels
Hotel Molinos Plaza
Interior

Hotel Molinos Plaza

3.5 star property
9.0 out of 10, Wonderful, (44)
"The hotel staff was very helpful and kind. "
Hotel Molinos Plaza
Laureles Guest House - LGH Hotel
Lobby lounge

Laureles Guest House - LGH Hotel

3.5 star property
9.2 out of 10, Wonderful, (70)
"Staff was excellent. Helpful, supportive, kind. Free breakfast was made fresh as ordered, and delicious."
The price is P1,991
P1,991 total
Sep 28 - Sep 29
Laureles Guest House - LGH Hotel
Aparta Hotel Portal del Rodeo
Dining room

Aparta Hotel Portal del Rodeo

3.5 star property
9.0 out of 10, Wonderful, (236)
"Everything was good .. 👍 nice place to stay with family very safe.. nice people.."
The price is P3,327
P3,327 total
Sep 27 - Sep 28
Aparta Hotel Portal del Rodeo
Hotel Santa Ana
City view

Hotel Santa Ana

4.0 star property
9.2 out of 10, Wonderful, (9)
"Excellent place to stay, ver nice staff and friendly "
The price is P4,127
P4,127 total
Sep 28 - Sep 29
Hotel Santa Ana
Soul Lifestyle Apartments
1 bedroom, premium bedding, pillowtop beds, in-room safe

Soul Lifestyle Apartments

3.5 star property
9.0 out of 10, Wonderful, (105)
"One of the best places to stay, super clean and new facility, the staff is amazing, the place is super secure "
Soul Lifestyle Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Landmark Hotel

Landmark Hotel

10/10 Excellent
"Very clean nice staff"
elvin 9-night trip
Posted 3 days ago
Landmark Hotel

Find out more about Santa Cruz

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

EP Casa Uribe Architecture Art & Nature: Visitors like this Santa Cruz vacation home rental. It is located in a shopping district and has an outdoor pool, a balcony, and laundry facilities to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.