Santa Cruz Vacation Rentals

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Check prices for these dates

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Santa Cruz vacation rentals

1 bedroom, free WiFi
Shabbat Hotel Boutique

Shabbat Hotel Boutique

Shabbat Hotel Boutique
2.0 star property
San Vicente
10.0 out of 10, Exceptional, (1)
The price is P3,648
P3,648 total
Dec 29 - Dec 30
Shabbat Hotel Boutique
Living area
Skyline Ecoliving

Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.2 out of 10, Wonderful, (37)
"Great all around. Incredible views."
United States
Victor
Skyline Ecoliving
Minibar, individually decorated, individually furnished, free WiFi
Wasikuna cabañas rurales tipo glamping

Wasikuna cabañas rurales tipo glamping

Wasikuna cabañas rurales tipo glamping
3.0 star property
Guarne
10.0 out of 10, Exceptional, (4)
"Nice place "
United States
GERARDO
Wasikuna cabañas rurales tipo glamping
Desk, laptop workspace, free WiFi
Cumbres Luxury Glamping

Cumbres Luxury Glamping

Cumbres Luxury Glamping
3.0 star property
Guarne
8.8 out of 10, Excellent, (3)
"Hot tub outside was an experience. Very clean "
United States
FRANK
The price is P6,027
P6,027 total
Jan 12 - Jan 13, 2026
Cumbres Luxury Glamping
Exterior
Country hotel near Jose Maria Cordova Airport

Country hotel near Jose Maria Cordova Airport

Country hotel near Jose Maria Cordova Airport
5.0 star property
Rionegro
7.6 out of 10, Good, (11)
"We had a really good experience. They were super helpful and friendly. "
Canada
Carolina
The price is P2,676
P10,448 total
Jan 12 - Jan 13, 2026
Country hotel near Jose Maria Cordova Airport
Exterior
Sky View Glamping

Sky View Glamping

Sky View Glamping
2.0 star property
Girardota
9.0 out of 10, Wonderful, (2)
"Great view and the hospitality was very good.. The cabins were clean. "
United States
Chris
The price is P6,344
P6,344 total
Jan 1 - Jan 2, 2026
Sky View Glamping
Dining
Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very Good, (466)
"Good property. "
United States
Ruth Marcela
Travelers Rio Verde Living Suites
Outdoor spa tub
Metropolitan Living by HOUSY

Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.4 out of 10, Exceptional, (29)
"Great location."
United States
Nekitta
The price is P2,547
P4,309 total
Dec 29 - Dec 30
Metropolitan Living by HOUSY
Lobby
Haven

Haven

Haven
4.0 star property
El Poblado
8.8 out of 10, Excellent, (642)
"Friendly staff, great rooftop bar and pool, very clean."
United States
Jason
The price is P6,436
P6,436 total
Jan 4 - Jan 5, 2026
Haven
Fridge, microwave, stovetop, cookware/dishes/utensils
PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU
3.0 star property
Rionegro
8.8 out of 10, Excellent, (42)
"Everything was perfect"
United States
Ancizar
PORTANOVA SUITES by ADVENTU
Minibar, desk, laptop workspace, blackout drapes
Mali Experience

Mali Experience

Mali Experience
3.0 star property
Rionegro
The price is P4,396
P4,396 total
Jan 3 - Jan 4, 2026
Mali Experience
Front of property
Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Hotel Rioverde- 5 minutos de cercanía al aeropuerto
4.5 star property
Rionegro
7.4 out of 10, Good, (56)
"Clean room and good amenities. Close to the airport which was useful after a long flight "
Australia
DAVID
Hotel Rioverde- 5 minutos de cercanía al aeropuerto
In-room safe, desk, laptop workspace, soundproofing
Go Living and Suites by Jalo

Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (80)
"Great place for a getaway"
United States
Mateusz
The price is P4,175
P4,175 total
Dec 29 - Dec 30
Go Living and Suites by Jalo
Terrace/patio
Royal Living Poblado

Royal Living Poblado

Royal Living Poblado
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (52)
"Comfortable and safe stay"
United States
Julian
Royal Living Poblado
Indoor pool, outdoor pool, sun loungers
York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton
4.0 star property
El Poblado
9.6 out of 10, Exceptional, (1427)
"The rooms were clean, the view was stunning, and the staff were incredibly friendly and professional."
United States
RAMON
The price is P7,646
P7,646 total
Jan 27 - Jan 28, 2026
York Medellin, Curio Collection by Hilton
In-room safe, desk, blackout drapes, free WiFi
Edificio Bloom

Edificio Bloom

Edificio Bloom
3.5 star property
Laureles - Estadio
The price is P2,580
P2,580 total
Dec 29 - Dec 30
Edificio Bloom
Private kitchen
Cabañas Cielo Verde

Cabañas Cielo Verde

Cabañas Cielo Verde
3.0 star property
Rionegro
The price is P6,344
P7,613 total
Dec 29 - Dec 30
Cabañas Cielo Verde
Down comforters, in-room safe, desk, laptop workspace
Firenze Lofts

Firenze Lofts

Firenze Lofts
3.0 star property
La América
9.6 out of 10, Exceptional, (380)
"Great place, quiet, clean and the staff was nice "
United States
maria
Firenze Lofts
Hallway
Edificio Cielo Verde

Edificio Cielo Verde

Edificio Cielo Verde
3.0 star property
Rionegro
The price is P8,247
P9,833 total
Dec 29 - Dec 30
Edificio Cielo Verde
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent
"Clean and spacious rooms. Staff was amazing. Very helpful"
Karamjit 3-night trip
Posted 3 hours ago
V Grand Hotel, a member of Radisson Individuals

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
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  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

La Gracia Hotel & Spa: Visitors like this Santa Cruz vacation home rental. It offers a terrace, a garden, and free WiFi to help you feel perfectly comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Explora Park, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.