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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Aug 28 - Aug 30
In two months
Oct 9 - Oct 11
In three months
Nov 6 - Nov 8
In four months
Dec 4 - Dec 6

Our top choices for Santa Cruz vacation rentals

1 bedroom, premium bedding, down comforters, in-room safe

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (291 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is P4,272
P4,272 total
Aug 16 - Aug 17
Portal del Rodeo ApartaHotel - Arkadia Mall
Lobby

2. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (721 reviews)
"Excellent food in the restaurant, with a beautiful view from the rooftop. Great staff!!"
United States
Miguel
The price is P5,561
P5,561 total
Aug 17 - Aug 18
Haven, A Design Hotel
Reception

3. Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1,155 reviews)
"Excelente hotel."
United States
Fernanda
The price is P5,244
P5,244 total
Sep 12 - Sep 13
Sites Hotel
Front of property

4. Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (273 reviews)
"Very Clean and Friendly Staff."
United States
Paul
The price is P6,399
P6,399 total
Aug 25 - Aug 26
Seissta Medellin
Free daily full breakfast

5. Laureles Guest House - LGH Hotel

Laureles Guest House - LGH Hotel
3.5 star property
Laureles
9.2 out of 10, Wonderful, (102 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is P2,866
P2,866 total
Aug 17 - Aug 18
Laureles Guest House - LGH Hotel
Restaurant

6. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (69 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is P2,537
P2,537 total
Sep 14 - Sep 15
Edificio Helena
In-room safe, blackout drapes, iron/ironing board (on request)

7. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (212 reviews)
"Great place.!"
United States
jeremy
The price is P3,969
P3,969 total
Sep 14 - Sep 15
Origen Local Suites
View from room

8. San Peter Suites

San Peter Suites
3.0 star property
Laureles
8.0 out of 10, Very Good, (54 reviews)
"This ia a great place, super relaxed and friendly staff "
United States
Duncan
The price is P3,855
P3,855 total
Sep 11 - Sep 12
San Peter Suites
Living area

9. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (43 reviews)
"Exelente servicio"
United States
Ernesto
The price is P3,700
P4,641 total
Aug 17 - Aug 18
Skyline Ecoliving
WiFi (free)

10. hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.8 out of 10, Excellent, (3 reviews)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is P1,899
P1,899 total
Aug 25 - Aug 26
hotel civitas medellin
View from room

11. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very Good, (484 reviews)
"Good"
United States
Christian
The price is P5,906
P5,906 total
Aug 17 - Aug 18
Travelers Rio Verde Living Suites
Living area

12. Alcázar de Oviedo By EE Hotels

Alcázar de Oviedo By EE Hotels
3.0 star property
El Poblado
9.4 out of 10, Exceptional, (178 reviews)
"Great"
United States
Jin
The price is P7,781
P7,781 total
Aug 15 - Aug 16
Alcázar de Oviedo By EE Hotels
1 bedroom, minibar, desk, iron/ironing board (on request)

13. Soy Local Provenza

Soy Local Provenza
3.0 star property
El Poblado
8.2 out of 10, Very Good, (150 reviews)
"Great location, great service."
United States
MELANY
The price is P3,298
P3,298 total
Aug 17 - Aug 18
Soy Local Provenza
Living area

14. Hotel Santa Ana

Hotel Santa Ana
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (39 reviews)
"Great location, superb staff and service and great breakfasts and food options."
United States
Juan Vicente
The price is P3,459
P3,459 total
Aug 31 - Sep 1
Hotel Santa Ana
1 bedroom, premium bedding, pillowtop beds, in-room safe

15. Soul Lifestyle Apartments

Soul Lifestyle Apartments
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (142 reviews)
"Great spot and very friendly staff who go out of their way to help you! Super good experience and very happy!"
United States
Matthew
The price is P8,251
P10,315 total
Aug 18 - Aug 19
Soul Lifestyle Apartments
Exterior

16. Botánica 106-estándar

Botánica 106-estándar
2.0 star property
El Poblado
Botánica 106-estándar
Egyptian cotton sheets, premium bedding, down comforters

17. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (139 reviews)
"All the staff were absolutely great with a special thanks to Andres and Santiago! The cleaning was great and the location very convenient to everything and honestly a lot quieter than most of Calle 70.. Would definitely recommend and hope to visit soon"
United States
Firas Ghazi
The price is P5,646
P7,415 total
Sep 1 - Sep 2
Factory Lofts
Front of property

18. Living 10-36 Dieztreintayseis Short & Long Term

Living 10-36 Dieztreintayseis Short & Long Term
3.5 star property
El Poblado
9.2 out of 10, Wonderful, (51 reviews)
"Loved the room I stayed in and the staff was always accommodating. Great Boutique Hotel to stay."
United States
Rob
The price is P4,574
P4,574 total
Aug 17 - Aug 18
Living 10-36 Dieztreintayseis Short & Long Term
Coffee shop

19. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (22 reviews)
"I love the people & I love the area. One of the best place to stay in Medellin. "
United States
Lusene
The price is P3,684
P3,684 total
Aug 16 - Aug 17
B 48 Living by B Rent
Jetted tub

20. GRES Apartamentos

GRES Apartamentos
3.0 star property
El Poblado
10.0 out of 10, Exceptional, (59 reviews)
"This will Always be the place I stay at when I’m in Medellin Wonderful service wonderful stay"
United States
Kenny
The price is P5,622
P5,622 total
Sep 12 - Sep 13
GRES Apartamentos
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent
"Cuarto me gusto"
eddie 3-night trip
Posted less than an hour ago
V Grand Hotel, a member of Radisson Individuals

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.