Santa Cruz Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Vacation Rentals in Santa Cruz

Hotel 10-36

2.5 star property
El Poblado
The price is P5,748
P5,748 total
Nov 25 - Nov 26
Hotel 10-36

Shabbat Hotel Boutique

2.0 star property
San Vicente
10.0 out of 10, Exceptional, (1)
The price is P4,159
P4,159 total
Nov 13 - Nov 14
Shabbat Hotel Boutique

Cumbres Luxury Glamping

3.0 star property
Guarne
8.8 out of 10, Excellent, (3)
"This place was what we needed for a few days. Relaxing in the mountains 20 minutes from the airport of Jose Maria Cordova Medellin. I've been to the city and love Medellin, but it gets a bit hectic at times and this place allows some perfect R&R with an incredible view of the Andes mountain range. It's private and safe and overall a great experience from the jacuzzi on the patio to the great bathroom. The overall attentiveness of the staff made the stay even more welcoming and incredible....
Canada
Anthony
The price is P5,965
P5,965 total
Nov 13 - Nov 14
Cumbres Luxury Glamping

Skyline Ecoliving

3.0 star property
El Rosario
9.0 out of 10, Wonderful, (32)
"What a beautiful cabin. Will def come back. 10/10"
United States
Ali
Skyline Ecoliving

Wasikuna cabañas rurales tipo glamping

3.0 star property
Guarne
10.0 out of 10, Exceptional, (4)
"Nice place "
United States
GERARDO
Wasikuna cabañas rurales tipo glamping

Sky View Glamping

2.0 star property
Girardota
The price is P6,150
P6,150 total
Nov 19 - Nov 20
Sky View Glamping

Haven

4.0 star property
El Poblado
8.8 out of 10, Excellent, (622)
"Everything about Haven is great. "
United States
Aaron
The price is P6,448
P6,448 total
Nov 13 - Nov 14
Haven

Casa Los Curazaos

3.5 star property
Rionegro
The price is P6,367
P6,367 total
Nov 18 - Nov 19
Casa Los Curazaos

Hotel Rioverde- 5 minutos de cercanía al aeropuerto

4.5 star property
Rionegro
7.6 out of 10, Good, (52)
"Is near the airport"
United States
Fred
Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Metropolitan Living by HOUSY

4.0 star property
San Diego
9.6 out of 10, Exceptional, (7)
"Room was really clean and look decent."
United States
Norman and Natalia
The price is P2,311
P2,311 total
Nov 13 - Nov 14
Metropolitan Living by HOUSY

PORTANOVA SUITES by ADVENTU

3.0 star property
Rionegro
8.6 out of 10, Excellent, (35)
"It’s ok. Not great. But clean and with a full kitchen. Not giving five stars because staff is not that useful and because the door is clearly not a door but a wooden table (its weird, but any 7 years old could break into it). "
United States
Jose
PORTANOVA SUITES by ADVENTU

APARTA HOTEL PROVENZA

2.0 star property
El Poblado
10.0 out of 10, Exceptional, (1)
"Everything was good, thanks."
United States
Melvin
The price is P3,138
P3,927 total
Nov 19 - Nov 20
APARTA HOTEL PROVENZA

Travelers Rio Verde Living Suites

3.5 star property
Rionegro
8.4 out of 10, Very Good, (457)
"Nice place to stay"
United States
Rene
Travelers Rio Verde Living Suites

Wake BioHotel

5.0 star property
El Poblado
8.4 out of 10, Very Good, (13)
"The hotel was simply awesome. A great place to recover, everything was immaculate. The lobby, the pool, the spa, the restaurant, the room, just everything was super clean. Coming back soon."
United States
Alejandro
The price is P14,855
P15,640 total
Nov 13 - Nov 14
Wake BioHotel

York Luxury Suites Medellín

4.0 star property
El Poblado
9.6 out of 10, Exceptional, (1390)
"Great place to stay !"
United States
Lendsey
The price is P9,699
P9,699 total
Dec 1 - Dec 2
York Luxury Suites Medellín

Cabañas Cielo Verde

3.0 star property
Rionegro
The price is P6,308
P7,570 total
Nov 13 - Nov 14
Cabañas Cielo Verde

Royal Living Poblado

4.0 star property
El Poblado
9.2 out of 10, Wonderful, (46)
"Great place"
United States
Dante
Royal Living Poblado

Edificio Cielo Verde

3.0 star property
Rionegro
The price is P8,200
P9,777 total
Nov 13 - Nov 14
Edificio Cielo Verde
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

La Gracia Hotel & Spa: Visitors like this Santa Cruz vacation home rental. It offers a terrace, a garden, and free WiFi to help you feel perfectly comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.