Santa Cruz Trips (flight + hotel)

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Top hotels in Santa Cruz

Hotel Dorado La 70

Hotel Dorado La 70

4 out of 5
Carrera 70 No 44 B-66, Laureles, Medellín
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (1,576 reviews)
"Hotel muy limpio incluyendo lo que es la habitación, el personal atento, buen desayuno. La comida del restaurante muy buena. Lo único que el mattre de la cama es muy duro pero al informarlo en recepción rápido resolvieron ese detalle. En fin, sí volvería a quedarme, me encantó!"

Reviewed on Jul 28, 2025

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Hotel Dorado La 70
Heiss Hotel - By Jalo

Heiss Hotel - By Jalo

4 out of 5
1460 Cra. 43F, Medellín, Antioquia
Fully refundable
9/10 Wonderful! (723 reviews)
"Love everthing"

Reviewed on Aug 6, 2025

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Heiss Hotel - By Jalo
York Luxury Suites Medellín

York Luxury Suites Medellín

4 out of 5
Carrera 43a 17sur 63, Medellín, Antioquia
Fully refundableReserve now, pay when you stay
The price is P11,691 per night from Aug 16 to Aug 17
P11,691
P11,691 total
Aug 16 - Aug 17
9.4/10 Exceptional! (1,261 reviews)
"Wonderful hotel. The view from the room was incredible. The breakfast was delicious and the staff was very kind a quick to respond to or requests. I would definitely come back again!"

Reviewed on Aug 2, 2025

York Luxury Suites Medellín
See all 4,251 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Santafé Mall

Santafé Mall

During your visit to Medellín, you can search for that perfect souvenir at Santafé Mall. Check out the lively bars or top-notch restaurants in this walkable area.

Santafé Mall
Pueblito Paisa featuring religious aspects and a church or cathedral

Pueblito Paisa

Take a trip back in time to a replica of a typical old town from the region with a stunning view of the new city.

Pueblito Paisa

El Tesoro Shopping Park

During your visit to Medellín, you can find the perfect gifts to bring home at El Tesoro Shopping Park. Check out the top-notch restaurants or lively bars in this walkable area.

El Tesoro Shopping Park

What to do in Santa Cruz

Comuna 13 Graffiti Tour with Street Food

Comuna 13 Graffiti Tour with Street Food

P916
per adult
98% of travellers recommend
Comuna 13 Graffiti Tour with Street Food
Pablo Escobar Tour Medellin

Pablo Escobar Tour Medellin

P1,928
per adult
82% of travellers recommend
Pablo Escobar Tour Medellin
SMALL GROUP Guatape tour with Luxury Boat, Meals and Llamas farm

SMALL GROUP Guatape tour with Luxury Boat, Meals and Llamas farm

P1,776
per adult
SMALL GROUP Guatape tour with Luxury Boat, Meals and Llamas farm
See all activities in Santa Cruz

Frequently asked questions

How much does a Santa Cruz vacation package cost?
You can grab a vacation package to this top destination on Expedia. However, how much your vacation to Santa Cruz costs will depend on factors like the length of stay, season and hotel choice.
What are the cheapest months to go to Santa Cruz?
To score cheap Santa Cruz vacation packages, organize your getaway outside of busy periods like public holidays and major festivals. You'll generally find lower prices and better availability for flights and hotels.
How many days is enough for Santa Cruz?
The ideal length for your Santa Cruz vacation depends on what you'd like to see. Generally, a handful of days to a week will give you time to tick off all the major sights and discover some hidden treasures along the way.
How to find the best Santa Cruz package deals?
Start your search for a Santa Cruz package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the perfect Santa Cruz package deal straight away, simply change your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz escape underway.
Is it cheaper to book a Santa Cruz vacation as a package?
An Expedia vacation package could score you significant savings when compared to booking accommodations and flights separately. Better still, you can personalize your Santa Cruz getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to Santa Cruz?
If you have your Santa Cruz vacation dates finalized, book as soon as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa Cruz?

  1. Choose the ideal time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to travel to Santa Cruz.
  2. Budget wisely: In addition to the price of your hotel, you should consider other expenses. These include transportation, food and flights. Also, set aside a little extra for unexpected costs that may arise during your trip to Santa Cruz.
  3. Decide how long to go away for: Now that you're up to speed on Santa Cruz, you can work out the ideal length of your vacation. Create a rough plan and allocate enough time to cover everything you want to see.
  4. Bundle your flights and hotel: Epic destination, check. Length of stay, check. All that's left now is to pick a Santa Cruz vacation package that brings all your bookings together.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.