Vacation Homes in Panama

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Aug 22 - Aug 24
In two weeks
Aug 29 - Aug 31
In one month
Sep 12 - Sep 14
In two months
Oct 10 - Oct 12

Featured Vacation Homes in Panama

Surfari Bocas
Private kitchen

Surfari Bocas

2.5 star property
9.0 out of 10, Wonderful, (50)
"Excelente !!"
The price is P1,788
P1,966 total
includes taxes & fees
Aug 19 - Aug 20
Surfari Bocas
Casa de Campo Mia
View from property

Casa de Campo Mia

2.5 star property
8.6 out of 10, Excellent, (18)
"gargona is a very nice place , the property is very nice though it may benifit from some maintenance improvements. generally it is very comfortable moderately priced specifically when compared to all the new high rises in the area. I definitely find it as a good choice for my money."
Casa de Campo Mia
Casa Little Italy
Private kitchen

Casa Little Italy

3.0 star property
6.0 out of 10, (1)
"Didn't accept credit card payment "
Casa Little Italy
Sand Dollar Villa
Boating

Sand Dollar Villa

3.5 star property
10.0 out of 10, Exceptional, (1)
"Excellent place !"
Sand Dollar Villa
Villa Nomada
Outdoor pool

Villa Nomada

3.5 star property
10.0 out of 10, Exceptional, (3)
Villa Nomada
Casa Piedra
Egyptian cotton sheets, premium bedding, memory foam beds

Casa Piedra

3.5 star property
Casa Piedra
Orange House - Over the Water Rental
Sundeck

Orange House - Over the Water Rental

3.0 star property
8.0 out of 10, Very Good, (1)
"Sehr freundlicher Empfang und wir konnten mit jeder Frage kommen, sie wurde stets beantwortet. Sehr schönes Anwesen, das ich gerne wieder besuchen würde. "
Orange House - Over the Water Rental
Casita Del Mar
Individually decorated, individually furnished, free WiFi, bed sheets

Casita Del Mar

3.5 star property
10.0 out of 10, Exceptional, (1)
"No hay suficientes palabras que hagan honor o lo maravilloso del sitio, la casa, la atencion. Es un paraiso terrenal. Imposible equipar mejor la casa, llevamos tantas cosas que ni falta hicieron ya que estaban en casa. El amanecer, el atardecer, el transcurrir del dia y de la noche es inexplicablemente asombroso en ese sitio. Deberia quitarles todos los puntos y calificarlos en 1 solo por quebrarnos el corazon de esa manera al tener que despedir la casa. Jejeje. Quien lea este mensaje y quiera...
Casita Del Mar
Casa Del Mar
Terrace/patio

Casa Del Mar

3.5 star property
Casa Del Mar
Purple House- Over the Water Rentals
Terrace/patio

Purple House- Over the Water Rentals

3.0 star property
6.0 out of 10, (1)
"House is exactly as on the website's picture. Very cute and stylish. Hosts are nice and informative. Neighborhood is a way too authentic - poor and dirty. "
Purple House- Over the Water Rentals
Coronado Hideaway with Private Pool
Exterior

Coronado Hideaway with Private Pool

2.0 star property
The price is P3,721
P5,806 total
includes taxes & fees
Aug 17 - Aug 18
Coronado Hideaway with Private Pool
Quinta Pavo Real by Acomodo
Room

Quinta Pavo Real by Acomodo

2.0 star property
Quinta Pavo Real by Acomodo
Casa De Las Olas
Property grounds

Casa De Las Olas

3.5 star property
Casa De Las Olas
Casa Portales by Acomodo Buenaventura
Room

Casa Portales by Acomodo Buenaventura

2.0 star property
Casa Portales by Acomodo Buenaventura
Casa Mirango Boquete
Food court

Casa Mirango Boquete

3.5 star property
10.0 out of 10, Exceptional, (2)
" CASA MIRANGO is a cozy, charming clean guest house in alto Boquete, Panama, complete with 2 bedrooms, 1 bath, dining room, living room, and kitchen. Accommodations exceeded expectations. Located in a well maintained, authentic, out of the way-non urban countryside setting. Not a hotel, no maid service, no pool on the premises, no problem. Mostly quiet except for roosters crowing at daybreak. With advance notice and for reasonable rates, proprietors offer roundtrip transport between airport and...
Casa Mirango Boquete
Villa Condesa Del Mar
Terrace/patio

Villa Condesa Del Mar

3.0 star property
Villa Condesa Del Mar
Casa Acomodo Casco Viejo 4bdr Historic Mansion
Room

Casa Acomodo Casco Viejo 4bdr Historic Mansion

2.0 star property
Casa Acomodo Casco Viejo 4bdr Historic Mansion
Marina beach house
Terrace/patio

Marina beach house

3.0 star property
Marina beach house
Hacienda mi Montañita
Garden

Hacienda mi Montañita

3.0 star property
6.0 out of 10, (5)
"b"
Hacienda mi Montañita
Pacific View
On the beach

Pacific View

3.5 star property
Pacific View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Panama Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Our stay here was excellent. The staff were very professional and polite. The food was amazing especially the breakfast. There were healthy options for everyone to choose from. The room was clean and the bed was very comfortable. I would definitely stay here again. "
Lurlene 1-night trip
Posted 11 hours ago
Hotel Riu Plaza Panama