Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the lively festivals and great live music in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed theater scene and great live music in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's fascinating museums and acclaimed art scene.
University of Houston
Enjoy the collegiate vibe around University of Houston, a top university in Houston. Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Houston Botanic Garden Entry Ticket
Houston City Tour and Downtown Aquarium All Rides Pass
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
Reviewed on Jul 27, 2025
Hotel Zaza Houston Museum District
Reviewed on Jul 30, 2025
The Whitehall Houston
Reviewed on Jul 31, 2025
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Reviewed on Aug 2, 2025
Hilton Houston Plaza/Medical Center
Reviewed on Aug 2, 2025
Club Quarters Hotel Downtown, Houston
Reviewed on Jul 31, 2025
Other neighbourhoods around South Main
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Houston Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Houston Museum District. You can visit top attractions like Houston Zoo and Children's Museum of Houston, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Houston Zoo or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Midtown
The restaurants and live music are just a few things visitors like about Midtown. Continental Club and Midtown Arts and Theater Center Houston are worthwhile spots to check out, and you can hop on the metro at McGowen Station or Ensemble/HCC Station to get around the larger area.