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South Main Hotels near Houston

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,388 reviews)
"Free parking.lobby is nice."
United States
Zhiguang
The price is P5,475
P6,406 total
includes taxes & fees
Aug 20 - Aug 21
Wyndham Houston at Reliant Park & Medical Center

2. Wingate Houston at Reliant Park & Medical Center

Wingate Houston at Reliant Park & Medical Center
3.0 star property
South Main
6.6 out of 10, (1,003 reviews)
"Good parking"
United States
joseph
The price is P4,424
P5,176 total
includes taxes & fees
Aug 18 - Aug 19
Wingate Houston at Reliant Park & Medical Center

3. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,008 reviews)
"Friendly staff. Nice comfortable room at a very reasonable rate. Lobby area was very clean. The pool area however left much to be desired; it was small and not clean at all."
United States
ken
The price is P6,006
P7,027 total
includes taxes & fees
Sep 8 - Sep 9
Comfort Suites Houston near Medical Center- NRG Stadium

4. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,002 reviews)
"Excellent customer service."
United States
Olavo
The price is P4,010
P4,691 total
includes taxes & fees
Aug 29 - Aug 30
Quality Inn & Suites NRG Park - Medical Center

5. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (891 reviews)
"This place had"
United States
Marvin
The price is P4,793
P5,608 total
includes taxes & fees
Sep 1 - Sep 2
Candlewood Suites Houston Medical Center by IHG

6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,008 reviews)
"My stay was great"
United States
Cheryl
The price is P7,005
P8,246 total
includes taxes & fees
Aug 20 - Aug 21
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

7. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,643 reviews)
"Great stay"
United States
Michael
The price is P7,687
P9,042 total
includes taxes & fees
Aug 20 - Aug 21
Hyatt Place Houston Medical Center

8. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,873 reviews)
"Beautiful hotel"
United States
Alyssa
The price is P9,019
P10,553 total
includes taxes & fees
Aug 22 - Aug 23
Blossom Hotel Houston, Curio Collection by Hilton

9. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,278 reviews)
"Very reliable hotel"
United States
Leland
The price is P7,457
P8,770 total
includes taxes & fees
Aug 22 - Aug 23
Hyatt House Houston Medical Center

10. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.4 out of 10, Very Good, (1,552 reviews)
"Great staff and room"
United States
Meryem
The price is P4,897
P6,037 total
includes taxes & fees
Aug 23 - Aug 24
Hotel Ylem

11. Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX
3.0 star property
Texas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,002 reviews)
"Is a nice hotel"
United States
Nelva
The price is P6,500
P7,605 total
includes taxes & fees
Aug 23 - Aug 24
Hilton Garden Inn Houston Medical Center, TX

12. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,183 reviews)
"Amazing property, friendly staff"
United States
Bailey
The price is P8,827
P10,987 total
includes taxes & fees
Sep 6 - Sep 7
The Westin Houston Medical Center/Museum District

13. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (403 reviews)
"Clean quiet rooms nice breakfast great staff"
United States
Keitha
The price is P4,977
P5,824 total
includes taxes & fees
Aug 18 - Aug 19
Best Western Plus Pearland/Houston Medical Center Hotel

14. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very Good, (1,820 reviews)
"excellent hotel"
United States
samuel
The price is P4,485
P5,247 total
includes taxes & fees
Aug 22 - Aug 23
DoubleTree by Hilton Hotel Houston - Greenway Plaza

15. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Tyson
The price is P6,500
P7,605 total
includes taxes & fees
Aug 22 - Aug 23
Home2 Suites by Hilton at the Galleria

16. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (2,102 reviews)
"Brilliant location and pool"
United Kingdom
Daniel
The price is P5,019
P5,944 total
includes taxes & fees
Sep 7 - Sep 8
Hilton Houston Plaza/Medical Center

17. Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1,570 reviews)
"I always stay at this hotel. Comfortable beds and breakfast is great!"
United States
Natasha
The price is P5,948
P7,000 total
includes taxes & fees
Aug 19 - Aug 20
Hyatt Place Houston/Galleria

18. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,006 reviews)
"Clean, reasonably priced, accommodating, helpful staff, great location."
United States
Sarah
The price is P14,232
P19,079 total
includes taxes & fees
Aug 17 - Aug 18
Hotel Zaza Houston Museum District

19. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,514 reviews)
"Beautiful place"
United States
Luis
The price is P5,530
P6,470 total
includes taxes & fees
Aug 23 - Aug 24
Drury Inn & Suites Houston Near the Galleria

20. Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
10.2 km from South Main
9.2 out of 10, Wonderful, (1,122 reviews)
"Clean rooms, friendly staff, and great breakfast."
United States
ROMAN
The price is P7,258
P8,492 total
includes taxes & fees
Aug 23 - Aug 24
Best Western Plus Downtown Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Desk, laptop workspace, iron/ironing board (on request)
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,008 reviews
View
Exterior
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,388 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
891 reviews
View
Lobby
Wingate Houston at Reliant Park & Medical Center
3.0 star property
6.6
1,003 reviews
View
Hypo-allergenic bedding available, in-room safe, desk, blackout drapes
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,002 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

Top South Main Hotel Reviews

Find out more about South Main

Top reasons to visit South Main

  • Cultural Hub: South Main features a vibrant blend of historic and modern universities, art museums, and cultural events, enriching the experience for visitors.
  • Entertainment Options: Enjoy music concerts, movie showings, and various campus events that cater to diverse interests.
  • Convenient Location: Its proximity to downtown Houston makes South Main an ideal base for exploring local attractions.
  • Dynamic Sports Scene: Engage in numerous sports activities, with notable venues like Stockton Arena and Ballpark.
  • Diverse Accommodations: Choose from a wide range of hotels and aparthotels, ensuring a comfortable stay for all types of travellers.

Find great hotels near South Main

South Main, Houston, offers a diverse selection of accommodations, including both hotels and aparthotels, catering to various traveller needs. With a focus on business amenities, pet-friendly options, and an inclusive atmosphere for the LGBTQIA community, visitors can enjoy a welcoming and comfortable stay. Whether you're searching for the best hotels or top choices in Stockton, South Main provides a remarkable array of lodging to enhance your holiday experience.

  • Club Quarters Hotel Downtown, Houston: This 4-star hotel embodies a blend of modern convenience and a vibrant shopping atmosphere, making it ideal for business travellers and pet owners alike. Located 11.3km from South Main, it features a welcoming pet policy that includes free amenities for furry companions. Guests can enjoy the convenience of being in a bustling shopping district while benefiting from amenities such as food and water bowls for pets, ensuring a comfortable stay for all members of the family. The hotel's focus on business travel is evident in its well-equipped facilities, catering to those who need to balance work and play.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: Situated 8.0km from South Main, this 4-star hotel is the epitome of family-friendly hospitality with a special emphasis on inclusivity for the LGBTQIA community. The hotel offers a warm and welcoming atmosphere, complemented by thoughtful amenities for children, including cribs and window guards. Guests love the signature DoubleTree chocolate chip cookie upon arrival, adding a delightful touch to their stay. The proximity to the Galleria's shopping and dining options makes it a prime choice for families seeking both comfort and convenience.
  • The Royal Sonesta Houston Galleria: Just 8.0km from South Main, this 4-star hotel is perfect for those who appreciate a luxurious shopping experience combined with pet-friendly policies. The Royal Sonesta offers a sophisticated atmosphere with amenities tailored to both business and leisure travellers. Its pet policy includes restrictions to ensure a pleasant stay for all guests while offering the convenience of being located in a vibrant shopping district. Guests are particularly fond of the elegant rooms and attentive service, making it a top choice for those seeking a stylish escape.

Where to stay near South Main

Visitors to South Main, Houston, will discover a vibrant mix of culture and urban charm. This neighbourhood boasts a convenient location near downtown, making it an ideal base for exploring local attractions. Enjoy family-friendly activities, experience the bustling atmosphere of Main Street, and indulge in the dynamic sports scene. With its friendly people and rich cultural experiences, South Main promises a memorable getaway that caters to both business and leisure travellers alike.

  • Houston: As a vibrant metropolis, Houston serves as the heart of South Main. This bustling city is a hub for family-oriented activities, business ventures, and entertainment experiences. With visitor numbers peaking in March, May, and July, Houston offers a dynamic atmosphere enriched with shopping centres, music concerts, and lively sports stadiums. Explore local landmarks such as the event conference venues and convention centres, which host a variety of attractions throughout the year, ensuring a memorable travel experience.
  • Texas Medical Center: Located a mere 3.2km from South Main, the Texas Medical Center is a distinguished neighbourhood renowned for its focus on business, culture, and education. Visitors flock here mainly in April, July, and September, drawn by its modern college universities and cutting-edge research facilities. The area boasts an array of shopping malls and centres, making it a convenient spot to combine leisure with learning. The nearby sports stadium adds an extra layer of excitement for sports enthusiasts.
  • Willow Meadows/Willowbend Area: Also situated 3.2km from South Main, the Willow Meadows/Willowbend Area invites travellers seeking a mix of business, sports, and city experiences. With peak visitation in March, May, and July, this neighbourhood is perfect for enjoying shopping centres, music concerts, and vibrant community events. Local landmarks, including sports facilities and modern educational institutions, contribute to the area's charm, making it a delightful destination for both relaxation and exploration.

Things to do near South Main

South Main offers a delightful mix of activities for sports enthusiasts and culture seekers alike. Enjoy educational opportunities, music concerts, and vibrant shopping experiences at the local mall centre. Be sure to catch movie showings and engage in various campus events, all set against the backdrop of Houston's dynamic atmosphere. Whether you're in the mood for entertainment or learning, South Main has something to offer every visitor.

Shopping

Experience shopping in South Main with nearby gems like The Galleria, 8.0km away, offering a vibrant mix of entertainment and family-friendly vibes. Also, visit River Oaks District, a public market just 8.0km away, where you’ll find a blend of city and business atmospheres for unique gifts.

Recreation

At the nearby NRG Astrodome, immerse yourself in the exhilarating atmosphere of live sports events. Experience the upscale charm of the Houston Polo Club, where you can indulge in luxury while enjoying polo matches. The Toyota Center offers a vibrant sports environment, perfect for an energetic outing.

Adventure

Experience the thrill of free-fall at iFLY Indoor Skydiving, located 16.1km from South Main. For family fun, visit Chancellors Family Center, 8.0km away, which offers various adventure activities. Also, enjoy a spirited game at Homer Ford Tennis Center, situated 8.0km from South Main.

Nightlife

The nightlife in South Main offers a delightful mix. Enjoy a romantic show at Main Street Theater, or catch a family-friendly film at Regal Edwards Greenway Grand Palace. For a bit of fun, head to Zuma Fun Center for arcade adventures that the whole family will enjoy.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for South Main

To save on your trip to South Main, consider visiting in August or December to January when accommodation prices are lower. Sundays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to filter for eco-friendly hotels and sort by price to find the best deals. Additionally, book a package deal that combines flights, accommodation, and activities for added savings. Explore free attractions in the area and utilise public transport for an economical way to get around, ensuring a budget-friendly experience.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to customise your preferences, such as your budget, preferred location, and the type of hotel you desire. For instance, selecting the Eco-certified filter will showcase sustainable and eco-friendly accommodation options currently available. To find the most affordable prices and best deals, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your South Main hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near South Main

South Main in Houston, Texas, offers a diverse range of activities ideal for sports enthusiasts, business travellers, and culture seekers alike. Visitors can explore historic and modern universities, as well as art museums, providing enriching experiences for families and culture lovers. Notable attractions include Stockton Arena and Stockton Ballpark, along with various nearby points of interest, ensuring a memorable stay for all who venture to this vibrant area.

  • Lakewood Church: Experience the vibrant atmosphere of Lakewood Church, known for its uplifting services and community spirit. This expansive venue, located 6.4km from South Main, hosts inspiring events and concerts, making it a cultural hub for visitors and locals alike.
  • Houston Baptist University: Discover the modern architecture and lively environment of Houston Baptist University, situated 9.7km from South Main. This institution boasts a diverse student body and offers various events, providing a genuine city vibe that reflects the heart of Houston.
  • Houston Center for Photography: Immerse yourself in the artistic world at the Houston Center for Photography, located 8.0km from South Main. This venue showcases stunning photographic exhibitions and workshops, celebrating creativity and culture in a welcoming setting.

Best time to go to South Main

The best time to visit South Main is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

Travelling to South Main, Houston, is convenient with three major airports nearby. Houston, TX (IAH-George Bush Intercontinental) is situated 35.4km away, offering excellent hotels like the DoubleTree by Hilton Houston Intercontinental Airport, 4.8km from the airport, and the Houston Airport Marriott at George Bush Intercontinental, which is located on-site. Alternatively, Houston, TX (HOU-William P. Hobby) is 14.5km away, with luxurious options such as the JW Marriott Houston Downtown. Lastly, Houston, TX (EFD-Ellington Field) lies 25.7km from South Main, featuring hotels like the Doubletree by Hilton Houston Hobby Airport, 11.3km from the airport. Each airport provides efficient transportation services to their respective hotels.

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.