Photo by Hazem Abdul

South Main Hotels near Houston

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near South Main, Houston

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (256)
"Nice place at a good rate "
The price is P3,490
P4,083 total
includes taxes & fees
Aug 4 - Aug 5
Bluestar Inn

Signature Inn Houston Galleria

2.5 star property
8.4 out of 10, Very Good, (527)
"The room was stinky and comfortable looked thin, itchy and unsanitary. The hotel give motels vibes."
The price is P3,560
P4,165 total
includes taxes & fees
Aug 9 - Aug 10
Signature Inn Houston Galleria

Americas Best Value Inn & Suites NE Houston Downtown I-610

2.0 star property
8.6 out of 10, Excellent, (602)
"Nice place. Amazing staff "
The price is P3,609
P4,223 total
includes taxes & fees
Aug 10 - Aug 11
Americas Best Value Inn & Suites NE Houston Downtown I-610

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (787)
"Will definitely be back again!"
The price is P4,130
P4,832 total
includes taxes & fees
Aug 22 - Aug 23
Candlewood Suites Houston Medical Center by IHG

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1134)
"A well kept hotel with great service and atmosphere."
The price is P4,895
P5,726 total
includes taxes & fees
Aug 4 - Aug 5
Wyndham Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.4 out of 10, (1004)
"Great place to stay right next to the NRG stadium "
The price is P3,429
P4,012 total
includes taxes & fees
Sep 1 - Sep 2
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (930)
"Great location, rooms were hot/warm. Needs a huge make over."
The price is P3,906
P4,569 total
includes taxes & fees
Sep 1 - Sep 2
Wingate Houston near NRG Park/Medical Center

Palace Inn Blue Edgebrook

2.5 star property
9.6 out of 10, Exceptional, (126)
"Really great hospitality"
The price is P4,758
P5,733 total
includes taxes & fees
Aug 4 - Aug 5
Palace Inn Blue Edgebrook

Prestige Inn

2.5 star property
8.6 out of 10, Excellent, (231)
"Staff is nice and property is clean !!!"
Prestige Inn

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (536)
"Awesome Hotel love the vibe!!"
The price is P6,224
P7,418 total
includes taxes & fees
Aug 31 - Sep 1
Moxy Houston Downtown

Palace Inn Westpark

2.0 star property
8.8 out of 10, Excellent, (122)
"The staff was very helpful and friendly. "
The price is P4,653
P5,444 total
includes taxes & fees
Aug 4 - Aug 5
Palace Inn Westpark

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1065)
"We loved our stay. Great room, staff, and service."
The price is P6,456
P7,594 total
includes taxes & fees
Aug 9 - Aug 10
Hyatt House Houston Medical Center

Americas Best Value Inn NRG Park Medical Center

2.0 star property
7.8 out of 10, Good, (764)
"Excellent location for one or two nights near the stadium for a concert. Clean and super nice check in staff"
The price is P4,188
P4,900 total
includes taxes & fees
Aug 4 - Aug 5
Americas Best Value Inn NRG Park Medical Center

Palace Inn 290 & Jones Rd

2.5 star property
8.8 out of 10, Excellent, (450)
"Always a great stay "
The price is P3,432
P4,015 total
includes taxes & fees
Aug 4 - Aug 5
Palace Inn 290 & Jones Rd

Four Points by Sheraton Houston West

3.5 star property
8.2 out of 10, Very Good, (566)
"I have no complaints, it was such a nice hotel. Quiet, clean, helpful and friendly staff. "
The price is P5,467
P6,397 total
includes taxes & fees
Aug 10 - Aug 11
Four Points by Sheraton Houston West

Hotel Park Place

2.5 star property
9.0 out of 10, Wonderful, (149)
"This place is amazing place to stay at "
The price is P4,130
P4,832 total
includes taxes & fees
Aug 4 - Aug 5
Hotel Park Place

WoodSpring Suites Houston Northwest

2.5 star property
7.6 out of 10, Good, (475)
"Enjoy the stay"
The price is P3,257
P3,745 total
includes taxes & fees
Sep 1 - Sep 2
WoodSpring Suites Houston Northwest

Americas Best Value Inn Medical Center Downtown

2.0 star property
7.8 out of 10, Good, (1000)
"Highly recommended.. I will stay again."
The price is P4,345
P5,083 total
includes taxes & fees
Aug 4 - Aug 5
Americas Best Value Inn Medical Center Downtown

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

3.0 star property
8.8 out of 10, Excellent, (1483)
"Nice place"
The price is P4,758
P5,597 total
includes taxes & fees
Aug 24 - Aug 25
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

The Residency Suites

2.0 star property
9.0 out of 10, Wonderful, (219)
"I enjoyed my stay and the staff is super friendly "
The Residency Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston map

Downtown Houston

3 out of top 10 points of interest in this area

Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Toyota Center and Daikin Park are major draws, and you can catch the metro at Central Station Main or Theater District Station to see more of the city.

The Galleria map

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center map

Texas Medical Center

1 out of top 10 points of interest in this area

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose map

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District map

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 57 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.