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South Main Hotels near Houston

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Our top choices for South Main hotels

1. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,000 reviews)
"Great location."
United States
Sandra P
The price is P5,784
P6,767 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Suites Houston near Medical Center- NRG Stadium

2. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,519 reviews)
"Great stay!!"
United States
Matthew
The price is P6,309
P7,381 total
includes taxes & fees
Nov 16 - Nov 17
Wyndham Houston at Reliant Park & Medical Center

3. Wingate Houston near Reliant Park/Medical Center

Wingate Houston near Reliant Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,000 reviews)
"Great place"
United States
Crystal
The price is P5,672
P6,636 total
includes taxes & fees
Nov 16 - Nov 17
Wingate Houston near Reliant Park/Medical Center

4. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,004 reviews)
"We had a excellent stay"
United States
Jasmine
The price is P3,827
P4,477 total
includes taxes & fees
Dec 14 - Dec 15
Quality Inn & Suites NRG Park - Medical Center

5. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (903 reviews)
"Amazing friendly staff."
United States
Olga
The price is P4,971
P5,816 total
includes taxes & fees
Nov 17 - Nov 18
Candlewood Suites Houston Medical Center by IHG

6. 3 BR Condo near Reliant/NRG Stadium

3 BR Condo near Reliant/NRG Stadium
2.0 star property
South Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
United States
Jeffrey
The price is P7,206
P20,733 total
includes taxes & fees
Nov 16 - Nov 17
3 BR Condo near Reliant/NRG Stadium

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,003 reviews)
"Great stay."
United States
Francisco
The price is P7,520
P8,850 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

8. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,717 reviews)
"Great place to stay"
United States
Joel
The price is P7,931
P9,328 total
includes taxes & fees
Nov 20 - Nov 21
Hyatt Place Houston Medical Center

9. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,260 reviews)
"Clean rooms, helpful staff, and great breakfast."
United States
Nikki
The price is P7,931
P9,328 total
includes taxes & fees
Nov 21 - Nov 22
Hyatt House Houston Medical Center

10. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.2 out of 10, Very good, (1,606 reviews)
"Clean rooms, nice staff. Will definitely again."
United States
Angela
The price is P4,353
P5,411 total
includes taxes & fees
Nov 25 - Nov 26
Hotel Ylem

11. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
2.7 km from South Main
8.8 out of 10, Excellent, (1,004 reviews)
"The hotel was conveniently located for walking to Rice University and the room was clean and comfortable."
United States
Reagan
The price is P6,252
P7,390 total
includes taxes & fees
Dec 14 - Dec 15
Courtyard By Marriott Houston Medical Center Reliant Park

12. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,789 reviews)
"Great hotel definitely would stay again."
United States
Michael
The price is P9,354
P10,980 total
includes taxes & fees
Nov 22 - Nov 23
Blossom Hotel Houston, Curio Collection by Hilton

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,287 reviews)
"Great location and wonderful staff!"
United States
Cynthia
The price is P7,186
P8,945 total
includes taxes & fees
Nov 21 - Nov 22
The Westin Houston Medical Center/Museum District

14. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.6 out of 10, Excellent, (2,256 reviews)
"Very nice, would stay again!"
United States
Amanda
The price is P5,927
P7,008 total
includes taxes & fees
Nov 23 - Nov 24
Hilton Houston Plaza/Medical Center

15. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,103 reviews)
"Great place to stay."
United States
Jeffrey
The price is P6,741
P7,887 total
includes taxes & fees
Nov 22 - Nov 23
Home2 Suites by Hilton at the Galleria

16. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,757 reviews)
"Great stay"
United States
Lorenzo
The price is P4,206
P4,921 total
includes taxes & fees
Dec 14 - Dec 15
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

17. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.4 out of 10, Very good, (4,721 reviews)
"Great stay"
United States
Hernando
The price is P7,255
P8,549 total
includes taxes & fees
Nov 25 - Nov 26
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

18. Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1,689 reviews)
"Great place to stay"
Australia
Katrina
The price is P7,638
P8,978 total
includes taxes & fees
Nov 22 - Nov 23
Hyatt Place Houston/Galleria

19. Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX
3.0 star property
Texas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,003 reviews)
"Will stay again , highly recommend!"
United States
Shatara
The price is P6,741
P7,887 total
includes taxes & fees
Nov 21 - Nov 22
Hilton Garden Inn Houston Medical Center, TX

20. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,446 reviews)
"Great place to stay Would definitely come back"
United States
Bruce
The price is P7,583
P8,873 total
includes taxes & fees
Nov 23 - Nov 24
The Royal Sonesta Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with a reception desk, two sofas, a coffee station, and large windows providing natural light.
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,000 reviews
View
A person opening a wooden cabinet with multiple shelves, some containing kitchenware.
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
903 reviews
View
A modern dining area with a leather couch, a dining table with plates, a napkin, and two martini glasses.
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,519 reviews
View
A lobby with seating areas, a reception desk, and a view of the outdoors.
Wingate Houston near Reliant Park/Medical Center
3.0 star property
6.6
1,000 reviews
View
A modern hotel lobby with a leather sofa, a dining table, and chairs. There is a reception desk in the background with a large window.
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,004 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Find out more about South Main

Top reasons to visit South Main

  • Cultural Hub: South Main features a vibrant blend of historic and modern universities, art museums, and cultural events, enriching the experience for visitors.
  • Entertainment Options: Enjoy music concerts, movie showings, and various campus events that cater to diverse interests.
  • Convenient Location: Its proximity to downtown Houston makes South Main an ideal base for exploring local attractions.
  • Dynamic Sports Scene: Engage in numerous sports activities, with notable venues like Stockton Arena and Ballpark.
  • Diverse Accommodations: Choose from a wide range of hotels and aparthotels, ensuring a comfortable stay for all types of travellers.

Find great hotels near South Main

South Main, Houston, offers a diverse selection of accommodations, including both hotels and aparthotels, catering to various traveller needs. With a focus on business amenities, pet-friendly options, and an inclusive atmosphere for the LGBTQIA community, visitors can enjoy a welcoming and comfortable stay. Whether you're searching for the best hotels or top choices in Stockton, South Main provides a remarkable array of lodging to enhance your holiday experience.

  • Club Quarters Hotel Downtown, Houston: This 4-star hotel embodies a blend of modern convenience and a vibrant shopping atmosphere, making it ideal for business travellers and pet owners alike. Located 11.3km from South Main, it features a welcoming pet policy that includes free amenities for furry companions. Guests can enjoy the convenience of being in a bustling shopping district while benefiting from amenities such as food and water bowls for pets, ensuring a comfortable stay for all members of the family. The hotel's focus on business travel is evident in its well-equipped facilities, catering to those who need to balance work and play.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: Situated 8.0km from South Main, this 4-star hotel is the epitome of family-friendly hospitality with a special emphasis on inclusivity for the LGBTQIA community. The hotel offers a warm and welcoming atmosphere, complemented by thoughtful amenities for children, including cribs and window guards. Guests love the signature DoubleTree chocolate chip cookie upon arrival, adding a delightful touch to their stay. The proximity to the Galleria's shopping and dining options makes it a prime choice for families seeking both comfort and convenience.
  • The Royal Sonesta Houston Galleria: Just 8.0km from South Main, this 4-star hotel is perfect for those who appreciate a luxurious shopping experience combined with pet-friendly policies. The Royal Sonesta offers a sophisticated atmosphere with amenities tailored to both business and leisure travellers. Its pet policy includes restrictions to ensure a pleasant stay for all guests while offering the convenience of being located in a vibrant shopping district. Guests are particularly fond of the elegant rooms and attentive service, making it a top choice for those seeking a stylish escape.

Where to stay near South Main

Visitors to South Main, Houston, will discover a vibrant mix of culture and urban charm. This neighbourhood boasts a convenient location near downtown, making it an ideal base for exploring local attractions. Enjoy family-friendly activities, experience the bustling atmosphere of Main Street, and indulge in the dynamic sports scene. With its friendly people and rich cultural experiences, South Main promises a memorable getaway that caters to both business and leisure travellers alike.

  • Houston: As a vibrant metropolis, Houston serves as the heart of South Main. This bustling city is a hub for family-oriented activities, business ventures, and entertainment experiences. With visitor numbers peaking in March, May, and July, Houston offers a dynamic atmosphere enriched with shopping centres, music concerts, and lively sports stadiums. Explore local landmarks such as the event conference venues and convention centres, which host a variety of attractions throughout the year, ensuring a memorable travel experience.
  • Texas Medical Center: Located a mere 3.2km from South Main, the Texas Medical Center is a distinguished neighbourhood renowned for its focus on business, culture, and education. Visitors flock here mainly in April, July, and September, drawn by its modern college universities and cutting-edge research facilities. The area boasts an array of shopping malls and centres, making it a convenient spot to combine leisure with learning. The nearby sports stadium adds an extra layer of excitement for sports enthusiasts.
  • Willow Meadows/Willowbend Area: Also situated 3.2km from South Main, the Willow Meadows/Willowbend Area invites travellers seeking a mix of business, sports, and city experiences. With peak visitation in March, May, and July, this neighbourhood is perfect for enjoying shopping centres, music concerts, and vibrant community events. Local landmarks, including sports facilities and modern educational institutions, contribute to the area's charm, making it a delightful destination for both relaxation and exploration.

Things to do near South Main

South Main offers a delightful mix of activities for sports enthusiasts and culture seekers alike. Enjoy educational opportunities, music concerts, and vibrant shopping experiences at the local mall centre. Be sure to catch movie showings and engage in various campus events, all set against the backdrop of Houston's dynamic atmosphere. Whether you're in the mood for entertainment or learning, South Main has something to offer every visitor.

Shopping

Experience shopping in South Main with nearby gems like The Galleria, 8.0km away, offering a vibrant mix of entertainment and family-friendly vibes. Also, visit River Oaks District, a public market just 8.0km away, where you’ll find a blend of city and business atmospheres for unique gifts.

Recreation

At the nearby NRG Astrodome, immerse yourself in the exhilarating atmosphere of live sports events. Experience the upscale charm of the Houston Polo Club, where you can indulge in luxury while enjoying polo matches. The Toyota Center offers a vibrant sports environment, perfect for an energetic outing.

Adventure

Experience the thrill of free-fall at iFLY Indoor Skydiving, located 16.1km from South Main. For family fun, visit Chancellors Family Center, 8.0km away, which offers various adventure activities. Also, enjoy a spirited game at Homer Ford Tennis Center, situated 8.0km from South Main.

Nightlife

The nightlife in South Main offers a delightful mix. Enjoy a romantic show at Main Street Theater, or catch a family-friendly film at Regal Edwards Greenway Grand Palace. For a bit of fun, head to Zuma Fun Center for arcade adventures that the whole family will enjoy.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for South Main

To save on your trip to South Main, consider visiting in August or December to January when accommodation prices are lower. Sundays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to filter for eco-friendly hotels and sort by price to find the best deals. Additionally, book a package deal that combines flights, accommodation, and activities for added savings. Explore free attractions in the area and utilise public transport for an economical way to get around, ensuring a budget-friendly experience.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to customise your preferences, such as your budget, preferred location, and the type of hotel you desire. For instance, selecting the Eco-certified filter will showcase sustainable and eco-friendly accommodation options currently available. To find the most affordable prices and best deals, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your South Main hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near South Main

South Main in Houston, Texas, offers a diverse range of activities ideal for sports enthusiasts, business travellers, and culture seekers alike. Visitors can explore historic and modern universities, as well as art museums, providing enriching experiences for families and culture lovers. Notable attractions include Stockton Arena and Stockton Ballpark, along with various nearby points of interest, ensuring a memorable stay for all who venture to this vibrant area.

  • Lakewood Church: Experience the vibrant atmosphere of Lakewood Church, known for its uplifting services and community spirit. This expansive venue, located 6.4km from South Main, hosts inspiring events and concerts, making it a cultural hub for visitors and locals alike.
  • Houston Baptist University: Discover the modern architecture and lively environment of Houston Baptist University, situated 9.7km from South Main. This institution boasts a diverse student body and offers various events, providing a genuine city vibe that reflects the heart of Houston.
  • Houston Center for Photography: Immerse yourself in the artistic world at the Houston Center for Photography, located 8.0km from South Main. This venue showcases stunning photographic exhibitions and workshops, celebrating creativity and culture in a welcoming setting.

Best time to go to South Main

The best time to visit South Main is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

Travelling to South Main, Houston, is convenient with three major airports nearby. Houston, TX (IAH-George Bush Intercontinental) is situated 35.4km away, offering excellent hotels like the DoubleTree by Hilton Houston Intercontinental Airport, 4.8km from the airport, and the Houston Airport Marriott at George Bush Intercontinental, which is located on-site. Alternatively, Houston, TX (HOU-William P. Hobby) is 14.5km away, with luxurious options such as the JW Marriott Houston Downtown. Lastly, Houston, TX (EFD-Ellington Field) lies 25.7km from South Main, featuring hotels like the Doubletree by Hilton Houston Hobby Airport, 11.3km from the airport. Each airport provides efficient transportation services to their respective hotels.

Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to Reliant Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveler data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighborhood?
Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like Reliant Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.