Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's lively festivals and fascinating museums.
Space Center Houston
Visit the heart of the American space industry in the control centre that put man on the moon.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and great live music in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and entertainment choices in this vibrant area.
Things to do
Houston's Official City & Mural Tour!
Houston Museum of Natural Sciences: Planetarium Ticket
Space Center Houston Admission Ticket
Houston Museum of Natural Science General Admission Ticket
Houston Museum of Natural Science and Cockrell Butterfly Center
Houston: Houston Botanic Garden Entry Ticket
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great location and friendly staff. The room looked slightly dated, it was very clean, spacious and comfortable
Reviewed on Nov 15, 2025
Holiday Inn Houston Downtown by IHG
Ian at the front desk was fantastic. Good representative for the company. Room was clean.
Reviewed on Nov 16, 2025
The Royal Sonesta Houston Galleria
It was great
Reviewed on Nov 15, 2025
Blossom Hotel Houston, Curio Collection by Hilton
Great property, beautiful room, great staff!
Reviewed on Nov 15, 2025
Club Quarters Hotel Downtown, Houston
Good handicapped room, with space but needs bars to hold onto in shower, toilet has a bar but shower does not. Like the Nespresso machine in the room.
Reviewed on Nov 8, 2025
The Whitehall Houston
Great stay.
Reviewed on Nov 13, 2025
Other neighbourhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Midtown Arts and Theater Center Houston or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
