Panama City 4 Stars Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama City 4 Star Hotels

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Panama City 4-star hotels

Outdoor pool, pool umbrellas, sun loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
Tocumen
8.4 out of 10, Very Good, (2326)
"Great breakfast was included and the airport shuttle was conveniently located "
United States
Adrienne
The price is P6,462
P7,108 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Crowne Plaza Panama Airport by IHG
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very Good, (1317)
"Clean convenient beautiful hotel. "
United States
Daniel
The price is P15,591
P17,150 total
includes taxes & fees
Dec 29 - Dec 30
Megapolis Hotel Panamá
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is P9,220
P10,141 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Las Americas Golden Tower Panama
Terrace/patio
Marriott Panama Hotel

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1000)
"Great hotel and staff!"
United States
Catherine
The price is P9,458
P10,404 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Marriott Panama Hotel
Front of property
Novotel Panama City

Novotel Panama City

Novotel Panama City
4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1044)
"The hotel was very nice and the staff was great."
United States
Cena
The price is P6,398
P7,037 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Novotel Panama City
Restaurant
Studio Coliving

Studio Coliving

Studio Coliving
4.5 star property
Bella Vista
7.8 out of 10, Good, (585)
"Staff very helpful "
United States
Jean
Studio Coliving
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1466)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is P8,261
P9,087 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Decapolis Hotel Panama City
Outdoor pool, pool umbrellas, sun loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1128)
"The room was clean and the location was great."
United States
Wendy
The price is P5,757
P6,333 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Front of property - evening/night
American Trade Hotel

American Trade Hotel

American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (610)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
The price is P17,131
P18,844 total
includes taxes & fees
Jan 4 - Jan 5, 2026
American Trade Hotel
Terrace/patio
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (999)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is P7,878
P8,666 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sheraton Grand Panama
Outdoor pool
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
Bella Vista
9.0 out of 10, Wonderful, (628)
"Very great hotel and service "
United States
Prakash
The price is P4,308
P6,397 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Waymore Hotel Spa & Casino
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1005)
"Location Location Location! Clean, safe, beautiful. Loved it!"
United States
Sharon Gobern Dorray and Jason
The price is P6,442
P7,086 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Courtyard by Marriott Panama Metromall
Exterior
Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG
4.0 star property
Bella Vista
8.8 out of 10, Excellent, (1004)
"Clean room , friendly staff "
United States
Junique
The price is P4,700
P5,493 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Holiday Inn Panama Distrito Financiero by IHG
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
Casco Viejo
9.2 out of 10, Wonderful, (1009)
"Nice hotel in the historic center, excellent location for sightseeing and walking around at night."
United States
Antonio
The price is P20,932
P23,025 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Central Hotel Panama Casco Viejo
Exterior
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Staff was very helpful. Great location."
United States
John
The price is P5,443
P5,987 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Courtyard by Marriott Panama Multiplaza Mall
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, sun loungers
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (544)
"Room was clean and staff was courteous."
United States
John
The price is P9,928
P10,921 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Residence Inn by Marriott Panama City
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (139)
"Great hotel fair price"
United States
Santiago
The price is P9,209
P10,129 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hyatt Regency Panama City
Front of property
Hotel San Felipe

Hotel San Felipe

Hotel San Felipe
4.0 star property
Casco Viejo
9.4 out of 10, Exceptional, (254)
"Nice hotel, perfect area in the old quarter. Clean, comfortable, great staff. Highly recommend!"
Canada
Neil
The price is P6,852
P7,537 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Hotel San Felipe
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (259)
"Great location!"
United States
Erik
The price is P20,074
P22,081 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hotel La Compañía Casco Antiguo
2 outdoor pools, pool umbrellas, sun loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador
8.4 out of 10, Very Good, (1002)
"Wonderful staff and easy checkin!"
United States
Kristin
The price is P4,844
P5,328 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Radisson Hotel Panama Canal
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Panama City.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
The price is P7,194 per night from Jan 12 to Jan 13
P7,194
P7,913 total
Jan 12 - Jan 13, 2026
includes taxes & fees
9/10 Wonderful! (4,723 reviews)
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
Panoramic view at the Downtown of Panama City - Panama

Top Panama City Hotel Reviews

Novotel Panama City

Novotel Panama City

10/10 Excellent
"Bien ubicado bien servicio "
ADRIANA CORRALES 3-night trip
Posted 2 days ago
Novotel Panama City

Frequently asked questions

What are the best 4-star hotels in Panama City?
Continental Hotel Panamá is a 4-star hotel in Panama City that's popular among Expedia customers. An art gallery and proposal/romance packages are just a couple of its amenities. Travelers also recommend Hotel El Panama by Faranda Grand, a member of Radisson Individuals. From a swimming pool to a steam room, it offers conveniences that cater to every aspect of your relaxation and entertainment.
How much does it cost to stay in a 4-star hotel in Panama City?
To lock in a 4-star hotel in Panama City that fits your budget, make use of Expedia's handy search filters. Take a look at the availability during your vacation dates and use our pricing filter to set your limit. You can also sort your results by the most affordable escape first.

  • Search for the lowest price from P7,913

What's the difference between 5-star and 4-star hotels in Panama City?
Offering a friendly traveler experience and upmarket décor, 4-star hotels are a fantastic option for your Panama City vacation. These types of accommodations generally feature loads of useful amenities that make it a breeze to unpack and unwind — think 24-hour room service, gyms and pools. Or enjoy even more lavishness at a 5-star hotel designed to indulge you in high-end perks and amenities. Concierge assistance, complimentary toiletries and fine dining are typically included at these swanky properties.

Explore a world of travel with Expedia