Medical Center District Trips (flight + hotel)

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Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

4 out of top 10 points of interest in this area

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is P5,599 per night from Nov 10 to Nov 11
P5,599
P6,681 total
Nov 10 - Nov 11
includes taxes & fees
8.4/10 Very Good! (3,782 reviews)
"Good breakfast"

Reviewed on Nov 9, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is P5,876 per night from Dec 10 to Dec 11
P5,876
P7,049 total
Dec 10 - Dec 11
includes taxes & fees
8.6/10 Excellent! (1,201 reviews)
"Room was not cleaned well. Dust everywhere, bed skirt was frayed. Furniture was worn and scuffed pretty bad. I had to wipe the sink clean when I arrived because it was clearly dirty with makeup. There were dirt and crumbs on the floor, some bits of trash, appeared to not have been vacuumed. The windows ..."

Reviewed on Nov 9, 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is P5,674 per night from Nov 15 to Nov 16
P5,674
P6,771 total
Nov 15 - Nov 16
includes taxes & fees
Drury Inn & Suites San Antonio Northwest Medical Center
See all 4,933 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Medical Center District vacation package cost?
Starting from just , a vacation package is your passport to low-priced travel. Create your own Medical Center District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Center District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Center District vacation package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your vacation your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Medical Center District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Center District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Center are two of the most well-known hotels in Medical Center District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Center District vacation?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Center District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Center District vacation.
What should I know before booking a Medical Center District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Center District Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Center District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Center District vacation package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Center District vacation package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Stay near popular Medical Center District attractions

Cinemark San Antonio 16

You can take time to visit Cinemark San Antonio 16 during your travels to San Antonio.
See properties

Things to do

SEA LIFE San Antonio

SEA LIFE San Antonio

P1,632
per adult
76% of travellers recommend
SEA LIFE San Antonio
San Antonio: Witte Museum Admission Ticket

San Antonio: Witte Museum Admission Ticket

P1,065
per adult
86% of travellers recommend
San Antonio: Witte Museum Admission Ticket
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.