Medical Center District Hotels near San Antonio

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Our top choices for Medical Center District hotels

Pool
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1005)
"Everything was great, staff really kind ..."
United States
traci
The price is P5,287
P6,173 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Front of property
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3134)
"Great place "
United States
Amado
The price is P5,217
P6,166 total
includes taxes & fees
Dec 29 - Dec 30
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Exterior
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1006)
"Clean room, very close to medical center, and personnel at check in were very friendly."
United States
Melinda
The price is P5,228
P6,181 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott Medical Center San Antonio
Lobby
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1006)
"Best hotel!"
United States
Valeria
The price is P6,442
P7,655 total
includes taxes & fees
Jan 2 - Jan 3, 2026
San Antonio Marriott Northwest Medical Center
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1289)
"Great place to stay and visit "
United States
Harry
The price is P5,287
P6,249 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Inn & Suites San Antonio Northwest Medical Center
Premium bedding, pillowtop beds, in-room safe, desk
SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1001)
"good staff. good stay"
United States
Divya
The price is P5,933
P7,014 total
includes taxes & fees
Jan 10 - Jan 11, 2026
SpringHill Suites by Marriott San Antonio Medical Center/NW
Front of property
Atria Inn & Suites

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (274)
"Nice, comfortable space for a reasonable price. "
United States
Cynthia
Atria Inn & Suites
Free daily on-the-go breakfast
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1004)
"Easy and convenient location "
United States
Monique
The price is P3,446
P4,023 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Exterior
OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (226)
"Always great stay"
United States
Juan
The price is P3,172
P3,909 total
includes taxes & fees
Jan 11 - Jan 12, 2026
OYO Inn & Suites Medical Center San Antonio
Desk, laptop workspace, blackout drapes, free WiFi
Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.2 out of 10, Good, (222)
"Good stay and safe area"
United States
Mario
The price is P2,864
P3,344 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Studio 6 San Antonio, Tx - Northwest Medical Center
Reception
Park Inn by Radisson

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1001)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is P3,545
P4,139 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Park Inn by Radisson
Desk, laptop workspace, free WiFi, bed sheets
Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.6 out of 10, (795)
"Very convenient"
United States
Melony
The price is P2,796
P3,422 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Studio 6 San Antonio, TX - Medical Center
Desk, iron/ironing board, free WiFi, bed sheets
Flex Studios

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (498)
"heb is nearby. "
United States
Sayeed
The price is P2,432
P2,875 total
includes taxes & fees
Dec 29 - Dec 30
Flex Studios
Free WiFi, bed sheets
Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1000)
"Great experience "
United States
John
The price is P2,511
P2,969 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Motel 6 San Antonio, TX - Northwest Medical Center
Free continental breakfast on weekends
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
3.0 star property
9 km from Medical Center District
9.2 out of 10, Wonderful, (1121)
"Great clean hotel, we came in with my family happy and left happy! "
United States
Samuel
The price is P4,917
P5,741 total
includes taxes & fees
Jan 17 - Jan 18, 2026
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
Water park
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1318)
"Beautiful location and great staff"
United States
Miguel
The price is P4,195
P7,385 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Lobby
Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB
2.5 star property
7.7 km from Medical Center District
8.4 out of 10, Very Good, (1001)
"Great staff, loved the breakfast "
United States
Thomas
The price is P3,545
P4,139 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB
Indoor pool, outdoor pool
Courtyard by Marriott San Antonio SeaWorld - Westover Hills

Courtyard by Marriott San Antonio SeaWorld - Westover Hills

Courtyard by Marriott San Antonio SeaWorld - Westover Hills
3.0 star property
Far West Side, 12.1 km from Medical Center District
8.6 out of 10, Excellent, (1100)
"It was clean and quiet and the staff was as always amazing"
United States
Chastity
The price is P4,944
P5,874 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott San Antonio SeaWorld - Westover Hills
Lobby
SpringHill Suites by Marriott San Antonio SeaWorld Lackland

SpringHill Suites by Marriott San Antonio SeaWorld Lackland

SpringHill Suites by Marriott San Antonio SeaWorld Lackland
3.0 star property
Far West Side, 9.7 km from Medical Center District
8.2 out of 10, Very Good, (1003)
"It’s a clean and good place to stay"
United States
alfredo
The price is P4,195
P4,958 total
includes taxes & fees
Jan 1 - Jan 2, 2026
SpringHill Suites by Marriott San Antonio SeaWorld Lackland
Exterior
Best Western near Lackland AFB/SeaWorld

Best Western near Lackland AFB/SeaWorld

Best Western near Lackland AFB/SeaWorld
2.5 star property
Far West Side, 6.9 km from Medical Center District
8.0 out of 10, Very Good, (1135)
"Everything mentioned above, Like always comfortable !"
United States
Albert
The price is P3,246
P3,789 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Best Western near Lackland AFB/SeaWorld
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most.
Downtown - Riverwalk featuring heritage architecture, a river or creek and boating

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Uptown

While visiting Uptown, you might make a stop by sights like San Antonio River and Marion Koogler McNay Art Museum.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista while you're in town.

Near East Side

If you're spending some time in Near East Side, Alamodome and Carver Community Cultural Center are top sights worth seeing.

Top Medical Center District Hotel Reviews

Crockett Hotel

Crockett Hotel

10/10 Excellent
"Parking was easy and the hotel looked great"
Jody 1-night trip
Posted 14 hours ago
Crockett Hotel

Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Courtyard by Marriott Medical Center San Antonio.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute, and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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