Medical Center District

San Antonio

River walk in San Antonio
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
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Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is P4,833 per night from May 28 to May 29
P4,833
P5,713 total
May 28 - May 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (3,339 reviews)
Very comfortable stay! Bed was comfy! Shower had good water pressure. Breakfast was delicious!

Reviewed on May 7, 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is P6,111 per night from May 15 to May 16
P6,111
P7,261 total
May 15 - May 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (1,054 reviews)
Love this place. Nice and clean rooms.

Reviewed on May 5, 2026

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is P5,920 per night from May 17 to May 18
P5,920
P6,998 total
May 17 - May 18
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,009 reviews)
When I checked for a week and payed CASH IN TOWN FOR A MILITARY EVENT AT LACKLAND AFB DRIVE 25 hours, NO ONE INFORMED ME IF I HAD TO LEAVE EARLY I NEED TO GIVE A NOTICE OR THE HOTEL WOULD RETAIN A FEE OF 129.00. It just not a way to handle playing customers of over 25 years!

Reviewed on May 8, 2026

Courtyard by Marriott Medical Center San Antonio
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is P8,215 per night from May 20 to May 21
P8,215
P9,711 total
May 20 - May 21
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (4,602 reviews)
Breakfast was good although repetitive and fairly limited. For example, same thing every day. Sausage was tasty but never had bacon. I never found fruit. We did not use the pool. The employees were excellent and extremely helpful. Parking is a little pricey and the valet parking was slow at times. ...

Reviewed on May 7, 2026

Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is P5,383 per night from May 19 to May 20
P5,383
P6,363 total
May 19 - May 20
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (6,457 reviews)
Everything was good except that, they didn't include the parking in the hotel. But we end up getting valet parking and they were great.

Reviewed on May 8, 2026

Riverwalk Plaza
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
The price is P20,489 per night from May 12 to May 13
P20,489
P28,951 total
May 12 - May 13
includes taxes & fees
Book a stay at this golf hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,004 reviews)
Gorgeous place and jacob at the desk sang happy birthday to my wife upon check in! Beautiful stay!

Reviewed on Apr 28, 2026

Hyatt Regency Hill Country Resort and Villas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

SanAntonio_UniversityofTexasSanAntonio_502634_03

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

Northwest Side
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Shearer Hills - Ridgeview

If you're spending some time in Shearer Hills - Ridgeview, North Star Mall and San Pedro Driving Range & Par 3 Course are top sights worth seeing.

Shearer Hills - Ridgeview
River Walk in San Antonio, Texas

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or San Antonio River while you're exploring the area.

Midtown
Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
Tobin Hill

Tobin Hill

Though Tobin Hill might not have many top sights, you can venture to the surrounding area to see attractions like San Antonio Zoo and Aquarium and San Antonio Museum of Art.

Tobin Hill
Dallas Skyline Reflection on Trinity River During Sunset, Dallas, Texas.

Uptown

While visiting Uptown, you might make a stop by sights like San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum.

Uptown


Medical Center District