"We had an great time at this property. Amazing nightlight outside and short walk to the Vatican and hop on and off tours. The host was very helpful and assisted us in a taxi transfer at 3am with less than 12hours notice!!! Definitely recommend this location."
"My wife and I loved our stay here! It was a cute little spot that felt more like a local studio apartment than a hotel. The hosts were polite and helpful, the location was amazing, and we would recommend it to anyone visiting Rome! "
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
"Great staff. Great atmosphere. Clean hotel. Comfortable bed. Would recommend this hotel definitely can’t go wrong if you’re thinking where to stay. You’ll appreciate the simple mess with luxury and cozy at the same time. "
"I stayed with 3 of my longtime friends and was our first time visiting Rome in July 2025. The Quirinale combines old-world charm with modern comfort. Rooms are spacious with high ceilings and classic décor, and the buffet breakfast offers plenty of tasty choices in a lovely setting. The front desk and bell staff were welcoming and helpful throughout our stay. Location is excellent — close to Termini, the metro, and within walking distance of Rome’s main attractions. A perfect choice for travelers who want history, comfort, and convenience in the heart of the city."
"This hotel is well situated, near the Termini train station, walking distance from Basilica Sata Marcia Maggiore and San Giovanni Laterano. The rooms are clean, the staff is friendly, and we are sleeping very well with quiet at night. "
Learn about the local history of Rome with a stop at Complesso Monumentale Santo Spirito in Saxia. Experience the acclaimed theater scene and fascinating museums in this vibrant area.
What's the area like around Santo Spirito Hospital?
Santo Spirito Hospital is located in a historic area of Rome known for its stunning cathedral and notable monuments. If you're looking for a convenient place to stay, check out the 5155 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Santo Spirito Hospital?
How many hotels will I be able to find close to Santo Spirito Hospital?
Expedia has 5155 hotels and other accommodations within a mile from Santo Spirito Hospital.
If I need to cancel the hotel reservation for my stay near Santo Spirito Hospital, will I receive a refund?
Yes! The majority of hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to get top deals close to Santo Spirito Hospital.
Where can I learn more about changing or cancelling my trip in the area near Santo Spirito Hospital?
For more information about changing or cancelling your stay near Santo Spirito Hospital, head over to our customer service page.
What can I see and do near Santo Spirito Hospital?
You might want to spend some time browsing the exhibits at Vatican Museums, Castel Sant'Angelo, or Cloister of Bramante. Piazza Navona, Pantheon, and Trevi Fountain are well-known local landmarks worth a visit. You can check out the local talent at Auditorium Conciliazione, Paul VI Audience Hall, and Sistina Theater.
How can I get to Santo Spirito Hospital?
With so many choices for transportation, seeing all of the area near Santo Spirito Hospital is simple. You can access metro transit at Venezia Tram Stop, Arenula-Cairoli Tram Station, and Barberini Station. If you'd like to explore more of the area, hop aboard a train from Rome Piazzale Flaminio Station, Rome Termini Station, or Rome (XRJ-Termini Rail Station).
