Medical Center District

San Antonio

Photo by Linda Cronan
Photo by Linda Cronan

Popular places to visit

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

South Texas Medical Center

Though South Texas Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of San Antonio while you are here.

South Texas Medical Center

University of Texas Health and Science Center at San Antonio

Though University of Texas Health and Science Center at San Antonio might be what brings you to town, perhaps you'll have a chance to explore more of San Antonio while you are here.

University of Texas Health and Science Center at San Antonio

University Hospital - University Health System

Though University Hospital - University Health System might be what brings you to town, perhaps you'll have a chance to explore more of San Antonio while you are here.

University Hospital - University Health System

CHRISTUS Santa Rosa Hospital - Medical Center

Though CHRISTUS Santa Rosa Hospital - Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of San Antonio while you are here.

CHRISTUS Santa Rosa Hospital - Medical Center

Methodist Healthcare

Though Methodist Healthcare might be what brings you to town, perhaps you'll have a chance to explore more of San Antonio while you are here.

Methodist Healthcare

Things to do

San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

P2,052
per adult
92% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
SEA LIFE San Antonio

SEA LIFE San Antonio

P1,419
per adult
78% of travellers recommend
SEA LIFE San Antonio
San Antonio: Tower of the Americas Entry Ticket

San Antonio: Tower of the Americas Entry Ticket

P1,203
per adult
San Antonio: Tower of the Americas Entry Ticket
Best of San Antonio Tour

Best of San Antonio Tour

P9,347
per adult
94% of travellers recommend
Best of San Antonio Tour
San Antonio: San Antonio Zoo Any Day Ticket

San Antonio: San Antonio Zoo Any Day Ticket

P1,686
per adult
94% of travellers recommend
San Antonio: San Antonio Zoo Any Day Ticket
San Antonio: Witte Museum Admission Ticket

San Antonio: Witte Museum Admission Ticket

P969
per adult
74% of travellers recommend
San Antonio: Witte Museum Admission Ticket
See all activities in San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
The price is P5,073 per night from Sep 23 to Sep 24
P5,073
per night
Sep 23 - Sep 24
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,939 reviews)
"Charlotte, the night manager was very cordial. She even got my laptop to working. I had accidently hit a key that put it into sleep mode. Also, I could not figure out Analog and Digital on the TV. They sent a man up right away who showed me how to do that. The bed was comfortable too."

Reviewed on Sep 16, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
The price is P5,438 per night from Oct 3 to Oct 4
P5,438
per night
Oct 3 - Oct 4
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,010 reviews)
"Very comfortable beds, clean and quiet"

Reviewed on Sep 17, 2025

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
The price is P5,084 per night from Sep 28 to Sep 29
P5,084
per night
Sep 28 - Sep 29
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,005 reviews)
"The room"

Reviewed on Sep 20, 2025

Courtyard by Marriott Medical Center San Antonio
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
The price is P5,027 per night from Oct 19 to Oct 20
P5,027
per night
Oct 19 - Oct 20
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,014 reviews)
"Great location and facilities, people at the front desk super nice"

Reviewed on Sep 19, 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (5,809 reviews)
Cleanliness
"Although clean enough it was very dated and run down which made it look grubby. Info on QR about the menu in restaurant was wrong. Very disjointed building which made it hard to find room at start"

Reviewed on Sep 15, 2025

Get rates
Riverwalk Plaza
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
The price is P6,969 per night from Sep 28 to Sep 29
P6,969
per night
Sep 28 - Sep 29
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,754 reviews)
"The only problem was the cost of parking around your hotel. I have no problem with the cost. Could have been better if we knew the cost before hand."

Reviewed on Sep 16, 2025

Drury Plaza Hotel San Antonio Riverwalk
See all 4,627 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Los Angeles Heights

If you're looking for some top things to see and do in Northwest Los Angeles Heights and surrounding area, you can visit Alamo and Alamodome.

Northwest Los Angeles Heights
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Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

Northwest Side
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by The DoSeum or San Antonio Zoo and Aquarium while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Though Tobin Hill might not have many top sights, you can venture to the surrounding area to see attractions like Alamo and San Antonio Museum of Art.

Tobin Hill
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Uptown

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

Uptown

Medical Center District