Medical Center District

San Antonio

Photo by Linda Cronan

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is P5,076 per night from Jul 28 to Jul 29
P5,076
P6,000 total
Jul 28 - Jul 29
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,766 reviews)
"Ideal location everything was was within 6 minutes away"

Reviewed on Jul 20, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
The price is P4,985 per night from Aug 11 to Aug 12
P4,985
P5,923 total
Aug 11 - Aug 12
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,012 reviews)
"standard hotel but on top of service"

Reviewed on Jul 14, 2025

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
The price is P5,299 per night from Aug 2 to Aug 3
P5,299
P6,264 total
Aug 2 - Aug 3
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,007 reviews)
"Hotel was very clean and spacious. Just the smoke alarm went off for the entire hotel the night we stayed. The first floor going to the gym/pool smelled like smoke. Other than that my family and I enjoyed our stay. Would book again and I recommend it for families."

Reviewed on Jul 18, 2025

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (5,557 reviews)
"Very nice hotel, it’s an older hotel so hallways and certain things are outdated"

Reviewed on Jul 18, 2025

Riverwalk Plaza
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
The price is P6,859 per night from Aug 3 to Aug 4
P6,859
P8,108 total
Aug 3 - Aug 4
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,536 reviews)
"Wow! We loved this hotel. Highly recommend. It was a bank that was converted. We can’t say enough kind words about this hotel."

Reviewed on Jul 18, 2025

Drury Plaza Hotel San Antonio Riverwalk
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham, San Antonio, TX
The price is P5,483 per night from Aug 4 to Aug 5
P5,483
P6,481 total
Aug 4 - Aug 5
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,427 reviews)
"Will definitely be back"

Reviewed on Jul 21, 2025

Crockett Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Los Angeles Heights

If you're looking for some top things to see and do in Northwest Los Angeles Heights and surrounding area, you can visit San Antonio Zoo and Aquarium and Alamo.

Northwest Los Angeles Heights
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Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

Northwest Side
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Shearer Hills - Ridgeview

If you're spending some time in Shearer Hills - Ridgeview, North Star Mall and Blessed Sacrament Catholic Church are top sights worth seeing.

Shearer Hills - Ridgeview
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

If you're spending some time in Tobin Hill, San Antonio River and Temple Beth-El are top sights worth seeing.

Tobin Hill

Medical Center District