Photo by PhotoJoy

Hotels with Spa in Panama

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Top Cities in Panama

Check availability on Panama Hotels with Spa

Our top choices for Panama hotels with a spa

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Bella Vista
8.8 out of 10, Excellent, (1003)
"Amazing amazing service"
United States
KFIR
The price is P9,343
P10,277 total
includes taxes & fees
Dec 21 - Dec 22
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
Tocumen
8.4 out of 10, Very Good, (2328)
"Spacious room, clean, good breakfast "
United States
Juan
The price is P6,477
P8,100 total
includes taxes & fees
Dec 18 - Dec 19
Crowne Plaza Panama Airport by IHG

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (638)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is P13,177
P14,495 total
includes taxes & fees
Jan 17 - Jan 18, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1004)
"Great hotel and staff!"
United States
Catherine
The price is P8,330
P9,163 total
includes taxes & fees
Dec 21 - Dec 22
Marriott Panama Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1005)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is P11,788
P12,966 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Bristol Panama, a Registry Collection Hotel

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1008)
"Great vibes"
United States
Ashley
The price is P13,185
P14,503 total
includes taxes & fees
Jan 4 - Jan 5, 2026
W Panama

Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino
4.0 star property
Barrio Sur
8.2 out of 10, Very Good, (823)
"Staff was great room was clean"
United States
Bridgett
The price is P5,310
P5,841 total
includes taxes & fees
Dec 20 - Dec 21
Radisson Colon 2,000 Hotel & Casino

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (557)
"Great hotel and location "
United Kingdom
Russell
The price is P22,741
P25,015 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Sofitel Legend Casco Viejo, Panama City

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (993)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is P7,442
P8,186 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sheraton Grand Panama

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1002)
"Room was spacious and comfortable. Views are magnificent. Servece is excellent. Breakfast is good, but they were periodically running out some food "
United States
alexandra
The price is P12,419
P13,661 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hilton Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Panama Hotel Reviews

Explore a world of travel with Expedia