Upstate South Carolina Trips (flight + hotel)

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville featuring a garden, a bridge and fall colors

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Top hotels in Upstate South Carolina

Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is P7,708 per night from Aug 17 to Aug 18
P7,708
P8,733 total
Aug 17 - Aug 18
includes taxes & fees
8.6/10 Excellent! (1,004 reviews)
"Clean and nice place."

Reviewed on Aug 4, 2025

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
The price is P5,424 per night from Aug 24 to Aug 25
P5,424
P5,966 total
Aug 24 - Aug 25
includes taxes & fees
8.4/10 Very Good! (1,005 reviews)
"Staff was great hotel was clean"

Reviewed on Aug 8, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
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Wooded Cottage - 3 Mi to Clemson University
See all 2,826 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Fred W. Symmes Chapel

Fred W. Symmes Chapel

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

Fred W. Symmes Chapel

Haywood Mall

During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.

Haywood Mall

Frequently asked questions

How much does a Upstate South Carolina vacation package cost?
Our Upstate South Carolina vacation packages, which begin from just , are an awesome way to save loads of cash. Choose your preferred flights, hotels and rental cars to create your dream getaway.
How do I get a cheap travel package to Upstate South Carolina?
You'll save piles of cash if you bundle your hotels, flights and car rentals into a Upstate South Carolina vacation package. Sometimes cheap packages mean fewer options. But that's not the case with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of options to choose from. Eager to save even more? Add some fun activities to your package deal to unlock even bigger bargains! After all, travel is about more than simply getting to your destination.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the main things that attracts visitors to Upstate South Carolina, so it makes perfect sense that many choose to book their hotel in Greenville.
What are the top hotels in Upstate South Carolina?
Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall know how to make their guests feel at home in Greenville. If you also plan to explore Seneca, take a look at Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson. Both are very popular with travelers.
How far in advance should I book my Upstate South Carolina vacation?
It can be hard to know exactly when the best time is to book your Upstate South Carolina vacation. But typically the earlier you book, the more affordable the prices. Sometimes, you can lock in your flights and hotels up to 12 months prior to departure. If you're considering a last-minute getaway, no need to fret! There are plenty of fantastic bargains announced on Expedia every single day.
What does an Expedia Upstate South Carolina travel package include?
That depends on what sort of trip you have in mind. Upstate South Carolina vacation deals can include car rentals, flights and hotels. You can mix and match to find the travel package that suits your budget and style. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Upstate South Carolina travel package?
An Expedia travel package can be customized for your budget and is a fantastic way to make your budget go further. What you include is totally up to you. Rental cars, hotels and flights — decide on a combination that suits your style.
Can I choose my airline with a Upstate South Carolina Expedia vacation package?
Yes, of course. Expedia has access to more than 550 airline partners globally, so go with the carrier that best fits your budget and travel needs.
If I'm not able to travel, can I cancel my Upstate South Carolina vacation package?
If your travel plans in Upstate South Carolina have been upended, it's comforting to know that you can cancel your booking. If you made your booking in the last 24 hours, you may be eligible for a refund. If your booking was made more than 24 hours ago, your airline, hotel or car rental company may impose fees. To learn more, check our Customer Service Portal.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.