Photo by Ryan Coleman

Luxury Hotels in Sikeston, Missouri

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Sikeston Luxury Hotels

Top Sikeston Luxury Hotels

Days Inn and Suites by Wyndham Sikeston
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"The room was awesome and the building had a historical thing about it."
The price is P3,785
P4,314 total
includes taxes & fees
Aug 20 - Aug 21
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Excellent place to stay "
The price is P3,995
P4,507 total
includes taxes & fees
Aug 21 - Aug 22
Pear Tree Inn Cape Girardeau Near the Medical Center
Quality Inn
Lobby

Quality Inn

2.5 star property
7.0 out of 10, Good, (626)
"Staff was wonderful and helpful pool was great room was comfortable breakfast needs improvements decent for what they had "
The price is P3,514
P3,964 total
includes taxes & fees
Sep 7 - Sep 8
Quality Inn
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great location "
The price is P5,136
P5,905 total
includes taxes & fees
Aug 24 - Aug 25
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Business center

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (981)
"Easy access and parking"
The price is P5,136
P5,794 total
includes taxes & fees
Aug 22 - Aug 23
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Sikeston Hotel Reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"Always friendly and clean. My go to in the Cape!"
J. Blair 1-night trip
Posted 4 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"I am a sleep walker. The staff took really good care of me. They made accommodations to suit my situation. "
Hardy 3-night trip
Posted 11 days ago
Days Inn and Suites by Wyndham Sikeston

Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience all that Sikeston has to offer when you visit Sikeston Depot Museum, Central Park, and Front Street Studio & Art Gallery. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Hunter-Dawson State Historic Site.