San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

ATLAPA Conventions Center

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.

ATLAPA Conventions Center

Multicentro Panama

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Hospital Punta Pacífica

Though Hospital Punta Pacífica might be what brings you to town, perhaps you'll have a chance to explore more of Panama City while you are here.

Hospital Punta Pacífica

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Panama Canal Murals

You can learn about the history of Panama City with a visit to Panama Canal Murals. Stroll along the seaside in this vibrant area, or check out its lively bars.

Panama Canal Murals

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,371
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

P4,157
per adult
94% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
The Cathedral Basilica of Santa María La Antigua stands as a monumental beacon of faith, the first of its kind in America. Consecrated in 1796, its foundations were laid in 1688, marking over a centur

HALF-DAY City and Panama Canal Tour: Shared or Private

P4,663
per adult
100% of travellers recommend
HALF-DAY City and Panama Canal Tour: Shared or Private
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

P6,124
per adult
All included - Day tour in San Blas Islands - No extra fees
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

P8,034
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

P9,270
per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
See all activities in Panama City

Top hotels in San Francisco

Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is P7,304 per night from Jul 3 to Jul 4
P7,304
P8,034 total
Jul 3 - Jul 4
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (883 reviews)
"Ameh realizo magnifico servicio con nosotros. Muy amable y profesional , Saludos, los Cubanos 😅"

Reviewed on Jun 17, 2025

Sheraton Grand Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is P11,124 per night from Jul 18 to Jul 19
P11,124
P12,237 total
Jul 18 - Jul 19
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,001 reviews)
"Great staff."

Reviewed on Jun 10, 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is P5,829 per night from Jul 1 to Jul 2
P5,829
P6,412 total
Jul 1 - Jul 2
includes taxes & fees
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,004 reviews)
"I really like the stay in the property. It was easy to move around, nice restaurants and the shopping mall was close by . The hotel was clean and nice pool."

Reviewed on Jun 24, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
The price is P7,260 per night from Jun 27 to Jun 28
P7,260
P7,986 total
Jun 27 - Jun 28
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (925 reviews)
"Dining options were limited. the nightclub and sky bar or lounge were all closed. the bell staff and security were amazingly helpful. will recommend"

Reviewed on Jun 21, 2025

Megapolis Hotel Panamá
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
The price is P5,310 per night from Jun 26 to Jun 27
P5,310
P5,841 total
Jun 26 - Jun 27
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,212 reviews)
"Super cómodo. Acogedor,"

Reviewed on Jun 22, 2025

Decapolis Hotel Panama City
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
The price is P9,050 per night from Jul 6 to Jul 7
P9,050
P9,955 total
Jul 6 - Jul 7
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,005 reviews)
"The hotel is located in the most convenient spot in the city. The staff was helpful and friendly. However I was looking forward to the rooftop restaurant and lounge but it looks like it only for hosting events."

Reviewed on Jun 10, 2025

Las Americas Golden Tower Panama
See all 1,456 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around San Francisco

Summer time in Panama City, blue sky and sunny days to enjoy this city. #lifeatexpedia #PanamaCity #travel

Obarrio

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
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Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
Hard Rock Hotel Panama #StunningStructures

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
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Campo Alegre

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
Panama viejo

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo
Default Image

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

Bella Vista

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