San Francisco

Panama City

Photo by Hideki Yamagata
Photo by Hideki Yamagata
Photo by ‎James Barrow
Photo by ‎James Barrow
Photo by Adrian Damian
Photo by Adrian Damian
Photo by Nóra Széll
Photo by Nóra Széll
Photo by Panama Roadrunner
Photo by Panama Roadrunner

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall

ATLAPA Conventions Center

Learn about the events happening at ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area, or check out its lively bars.

ATLAPA Conventions Center

Pacific Center

You can enjoy retail therapy at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.

Pacific Center

Multicentro Panama

During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.

Multicentro Panama

Panama Canal Murals

You can learn about the history of Panama City with a visit to Panama Canal Murals. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.

Panama Canal Murals

Hospital Punta Pacífica

Though Hospital Punta Pacífica might be what brings you to town, perhaps you'll have a chance to explore more of Panama City while you are here.

Hospital Punta Pacífica

Things to do

Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,666
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Boat tour in the Panama Canal to Monkeys and sloths islands

Boat tour in the Panama Canal to Monkeys and sloths islands

P4,304
per adult
96% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
La casa de papel Day tour in San Blas Islands - All inclusive- No hidden fees.

All included - Day tour in San Blas Islands - No extra fees

P6,180
per adult
All included - Day tour in San Blas Islands - No extra fees
Full-Day SAN BLAS ISLAND & Snorkeling Tour + Transport from Panama City

Full-Day SAN BLAS ISLAND Tour + Transport from Panama City

P8,108
per adult
Full-Day SAN BLAS ISLAND Tour + Transport from Panama City
Live the Experience of a Full Day in San Blas

Live the Experience of a Full Day in San Blas

P8,788
per adult
100% of travellers recommend
Live the Experience of a Full Day in San Blas
Tour of Panama City and the Panama Canal

Tour of Panama City and the Panama Canal

P4,819
per adult
100% of travellers recommend
Tour of Panama City and the Panama Canal
See all activities in Panama City

Top hotels in San Francisco

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
The price is P7,650 per night from Aug 19 to Aug 20
P7,650
P8,415 total
Aug 19 - Aug 20
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (923 reviews)
"El hotel es super lindo y el desayuno es muy bueno. La atención también excelente."

Reviewed on Aug 6, 2025

Sheraton Grand Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is P12,559 per night from Aug 23 to Aug 24
P12,559
P13,815 total
Aug 23 - Aug 24
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,005 reviews)
"service 100/100"

Reviewed on Aug 9, 2025

JW Marriott Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is P7,247 per night from Aug 31 to Sep 1
P7,247
P7,972 total
Aug 31 - Sep 1
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (1,006 reviews)
"Everything was fantastic, however the bed sheets could be a little more clean, restock paper towel or hand towel in the bathroom and restock drinks as well as water :). The bathroom could be little more clean. Other than that everything was perfect."

Reviewed on Aug 10, 2025

Megapolis Hotel Panamá
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
The price is P6,401 per night from Sep 10 to Sep 11
P6,401
P7,041 total
Sep 10 - Sep 11
includes taxes & fees
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"Great stay, breakfast was excellent! Excellent location for touring Panama City, easy acess to bus stops and Metro."

Reviewed on Aug 11, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
The price is P5,421 per night from Aug 16 to Aug 17
P5,421
P5,963 total
Aug 16 - Aug 17
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,280 reviews)
Memorable Vacation
"The Decapolis hotel is nestled in the historic Casco Viejo district, an area accessible to transportation, food, restaurants, and close to the downtown center. This hotel along with the sister hotel, Megapolis provides a hot breakfast. Pretty good for the money. The restaurant has great food options. ..."

Reviewed on Aug 11, 2025

Decapolis Hotel Panama City
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
The price is P9,020 per night from Aug 14 to Aug 15
P9,020
P9,922 total
Aug 14 - Aug 15
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,097 reviews)
"Amazing! Would definitely stay again!"

Reviewed on Aug 9, 2025

Plaza Paitilla Inn Hotel
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Other neighbourhoods around San Francisco

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Obarrio

Unique features of Obarrio include the casinos and coffeehouses. Make a stop by Calle 50 or Soho City Center while you're exploring the area.

Obarrio
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Punta Pacifica

Notable for its seaside views, restaurants, and casinos, Punta Pacifica is a sought-after destination for many travelers visiting Panama City. If you want to see some sights in the area, check out Avenida Balboa or Multiplaza Pacific Mall.

Punta Pacifica
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Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Punta Paitilla
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Campo Alegre

If you're spending some time in Campo Alegre, Uruguay Street and Calle 50 are top sights worth seeing.

Campo Alegre
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El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

El Cangrejo
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Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

Bella Vista

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