Serra Mesa
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's entertainment choices and fascinating museums.
SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
San Diego: Museum of Illusions Entry Ticket
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego Whale Watching & Dolphin Cruise
Sunset Sail Along the San Diego Skyline
San Diego: 3 Hour Whale Watching Cruise
Top hotels in Serra Mesa
Paradise Point Resort & Spa
A very nice place, very well maintained, very friendly staff, I recommend it.
Reviewed on Feb 14, 2026
Hard Rock Hotel San Diego
One of the best hotels I’ve stayed but the view could’ve done better
Reviewed on Feb 13, 2026
The DEXTRO Little Italy, BW Premier Collection
Nice hotel i would stay here again.
Reviewed on Feb 13, 2026
The Sofia Hotel
We stayed on the 7th floor in one of the remodeled rooms and it was stunning! So clean. LOVED the nepresso maker. So tastefully decorated. We had a room with 2 beds and it was a bit small compared to other hotels but it was perfect for us, as we didn’t spend much time there anyway. Location was PERFECT! ...
Reviewed on Feb 10, 2026
Wyndham San Diego Bayside
Everything was good except toilet was clogged and problematic for all 4days. They good to waive our parking to compensate for the huge trouble and inconvenience. We appreciate that!! Ty
Reviewed on Feb 13, 2026
Days Inn by Wyndham San Diego Hotel Circle
The location was great, Hotel Circle is central to everything. The room was clean, the staff was excellent! We stayed in a kitchenette room and it was great to have. We'll stay there again!
Reviewed on Feb 12, 2026
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Old Town San Diego
The ample dining options and beautiful seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
