Panama City Trips (flight + hotel)

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Where to stay in Panama City

Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
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Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Panama City

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is P6,526 per night from Aug 25 to Aug 26
P6,526
P7,179 total
Aug 25 - Aug 26
includes taxes & fees
9/10 Wonderful! (4,163 reviews)
"Our stay here was excellent. The staff were very professional and polite. The food was amazing especially the breakfast. There were healthy options for everyone to choose from. The room was clean and the bed was very comfortable. I would definitely stay here again."

Reviewed on Aug 13, 2025

Hotel Riu Plaza Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is P7,187 per night from Aug 31 to Sep 1
P7,187
P7,906 total
Aug 31 - Sep 1
includes taxes & fees
8.4/10 Very Good! (925 reviews)
"El hotel es super lindo y el desayuno es muy bueno. La atención también excelente."

Reviewed on Aug 6, 2025

Sheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
The price is P4,596 per night from Aug 16 to Aug 17
P4,596
P5,056 total
Aug 16 - Aug 17
includes taxes & fees
9/10 Wonderful! (405 reviews)
"The check-in process was quick and easy although there was only one person working and there were several persons waiting to check-in. The room and lobby area were clean. The breakfast had several options which was great. I stayed there during the week previously abd the brekafast was the normal ..."

Reviewed on Aug 11, 2025

Waymore Hotel Spa & Casino
See all 1,437 properties in Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Fuerte Amador Resort & Marina

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Check out the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina

What to do in Panama City

Slingshot Tour Panama

Slingshot Tour Panama

P6,751
per adult
76% of travellers recommend
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

P8,666
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

P1,867
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in Panama City

Frequently asked questions

How much does a Panama City vacation package cost?
You can pick up a vacation package to this destination on Expedia. However, how much your vacation to Panama City costs will depend on factors like your hotel choice, length of stay and season.
What are the cheapest months to go to Panama City?
You're likely to find lower rates and better availability in September, October and November. Take a look at our cheap Panama City vacation packages and you could get some great off-season discounts.
How many days is enough for Panama City?
Dedicate around 3 days for your Panama City vacation in order to discover everything that makes this destination special. Stroll around popular areas, including San Francisco and Campo Alegre. Then check out major sights such as Metropolitan Cathedral of Panama and National Theater. With a good itinerary, you can keep busy with room for some rest time too. Want to travel beyond Panama City? Consider squeezing in an excursion or two.
Is it worth booking a vacation package to Panama City?
Popular for its nature, nightlife and culture, a Panama City vacation is a hit with all types of travelers. Be sure to visit leading sights like Albrook Shopping Mall and Cinta Costera, and consider renting a car for day trips to explore even more.
How to find the best Panama City package deals?
Landing a cheap Panama City package deal is a cinch with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Panama City package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are typically lower.
Is it cheaper to book a Panama City vacation as a package?
You can enjoy significant savings on your Panama City getaway by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to Panama City?
Enjoy incredible discounts by booking your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Panama City trip.
How to plan a trip to Panama City?

  1. Choose when to go: Check your schedule and get your bags packed. Your preferred time of year and the available activities will also help you decide when to visit Panama City.
  2. Plan your budget wisely: As well as the cost of your stay, you'll need to factor in other expenses too. These include food, flights and transportation. Also, put aside a little extra for unexpected costs that could arise during your trip to Panama City.
  3. Work out your trip length: Think about how long you want to spend exploring Panama City. Plan your itinerary so you can get to all the attractions and activities you're interested in at a leisurely pace.
  4. Bundle your bookings: With your travel dates in order, you can combine your car rental, hotels, flights and more into a customized Panama City vacation package.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.