A red train on tracks, palm trees, and modern buildings.

Luxury Hotels in Central San Diego, San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Central San Diego Luxury Hotels

Tonight
Sep 24 - Sep 25
Tomorrow
Sep 25 - Sep 26
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Central San Diego luxury hotels

An outdoor patio with a stone fire pit, outdoor seating, string lights, and a tall, narrow heater.
A swimming pool with a visible water filtration system and a tiled edge.
A beach with clear skies, a rocky cliff, and a lighthouse in the distance.
A hotel room with a large bed, a chair, a nightstand, and a lamp.

1. Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
University City
P12,043
P15,627 total
includes taxes & fees
Sep 27 - Sep 28
Embassy Suites by Hilton San Diego La Jolla
A bar area with a glass ceiling, a central bar counter, and multiple stools.
A dimly lit room with patterned walls, a wooden table, and a chair.
A luxurious interior with a large chandelier, patterned sofas, and a view of a cityscape through a large window.
A large swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a striped facade.

2. Lafayette Hotel & Club

Lafayette Hotel & Club
University Heights
P17,098
P19,654 total
includes taxes & fees
Sep 28 - Sep 29
Lafayette Hotel & Club
An outdoor dining area with tables and chairs, a fire feature, and a bar area with a stone wall and shelves.
A hotel entrance with a covered outdoor seating area, palm trees, and a car parked in front.
A swimming pool with lounge chairs and umbrellas, surrounded by trees and a tall building in the background.
A spacious gym with various exercise equipment, large windows, and a wooden floor.

3. San Diego Marriott La Jolla

San Diego Marriott La Jolla
University City
P12,191
P14,020 total
includes taxes & fees
Oct 24 - Oct 25
San Diego Marriott La Jolla
An outdoor lounge area with seating, a fire feature, and a pool in the background.
A hotel with a large pool surrounded by lounge chairs and umbrellas, palm trees, and a well-lit building facade.
A modern restaurant with multiple seating areas, including booths and tables. There are hanging lights and a variety of plants.
A stone wall with a neon sign that reads "Tom & Jerry."

4. Town and Country San Diego

Town and Country San Diego
Mission Valley
P14,321
P18,622 total
includes taxes & fees
Sep 25 - Sep 26
Town and Country San Diego
A rooftop pool area with lounge chairs, a fire pit, and string lights.
A modern bar area with a long counter, multiple seating options, and pendant lighting.
A hotel room with a large bed, a sofa, a round table, and a view of buildings through the windows.
A spacious lobby with high ceilings, a central staircase, and bookshelves along the walls.

5. Hyatt Regency La Jolla

Hyatt Regency La Jolla
University City
P12,714
P16,663 total
includes taxes & fees
Oct 23 - Oct 24
Hyatt Regency La Jolla
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A pathway leading to a building labeled "LEGACY Hotel."
A swimming pool with blue lounge chairs and umbrellas, surrounded by a building with balconies.
A modern interior with wooden panel ceilings, patterned seating, and a central bar area.

6. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
P9,770
P11,231 total
includes taxes & fees
Sep 29 - Sep 30
Legacy Resort Hotel & Spa
An outdoor dining area with tables set for two, string lights overhead, and a view of a building in the background.
A spacious lobby with a modern staircase, comfortable seating, and large windows offering natural light.
A modern interior with a seating area featuring round tables and chairs, a large mirror, and a unique ceiling light fixture.
A modern lobby with a large window, two sofas, and two black planters with plants.

7. Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
Mission Valley
P7,652
P8,796 total
includes taxes & fees
Sep 30 - Oct 1
Hilton San Diego Mission Valley
An outdoor patio with tables and chairs, string lights, and umbrellas.
A hotel room with a large bed, a TV, a desk with a chair, and a view of the city through large windows.
A modern room with a glass dining table, two bar stools, a sofa, and a TV stand with decorative items.

8. Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
Mission Valley
P10,647
P12,239 total
includes taxes & fees
Sep 28 - Sep 29
Sheraton Mission Valley San Diego Hotel
An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.
A poolside area with a concrete pool, lounge chairs, and a wooden deck.
A spacious lobby with a central seating area, a staircase, and a view of the hallway leading to the entrance.
A modern dining area with a large table, chairs, and hanging plants.

9. DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
Mission Valley
P8,166
P9,386 total
includes taxes & fees
Sep 27 - Sep 28
DoubleTree by Hilton Hotel San Diego - Mission Valley
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.
A modern bedroom with a large bed, a nightstand, a wall-mounted lamp, and a window with curtains.
A modern reception desk with a glass top, a large window offering a view, and a potted plant.
An outdoor seating area with sofas and chairs, a wooden staircase, and potted plants.

10. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
Middletown
  • Luxury retreat with rooftop terrace offers champagne service near San Diego Bay.
P7,453
P10,532 total
includes taxes & fees
Oct 13 - Oct 14
City24 Hotel Little Italy Mission Hills
View all properties

Top Central San Diego Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

10/10 Excellent
"We came out for a quick weekend trip from Vegas . Weather was amazing ! Hotel was very clean , comfy beds , nice staff. Breakfast is the only thing o was disappointed in . The only good thing was the waffles , toast , and bagels . That’s carbs carbs on top of carbs. Eggs tastes like they came out of a box and the meat , smelled like dog food w a blend taste yuck . Potatoes were cold and tasted old , again maybe boxed . Definitely did not enjoy the “free breakfast “ so we made sure to go out to breakfast the next morning. We went found to pacific beach and ate at a burrito spot called Early Bird very highly recommended. Other than that . Yes I would stay here again ."
Carolina 2-night trip
Posted 1 hour ago
Hampton Inn San Diego/Mission Valley
California Suites Hotel

California Suites Hotel

10/10 Excellent
"Great place"
Yvette 1-night trip
Posted 1 hour ago
California Suites Hotel
Kings Inn San Diego

Kings Inn San Diego

10/10 Excellent
"We enjoyed our stay at Kings Inn. The price was reasonable and it is in a good location. The restaurant was great and we will probably stay there again the next time we are in San Diego."
Anthony 1-night trip
Posted 1 hour ago
Kings Inn San Diego
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

8/10 Good
"The lobby was clean and the staff was nice. My unit was upstairs and it was clean and smelled really good too the only thing was the bathroom doesn’t have a working fan so I showered with the window open….you’re welcome."
Robert 1-night trip
Posted 2 days ago
The Atwood Hotel San Diego - SeaWorld/Zoo
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

10/10 Excellent
"Affordability and location can’t be beat. Staff is extremely helpful and attentive, and the amenities are great."
Karla 1-night trip
Posted 2 days ago
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Explore a world of travel with Expedia