Upstate South Carolina 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

Next weekend
In two weeks

Our top choices for Upstate South Carolina 4-star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (480 reviews)
"Great restaurant, hospitality was on point, and beautifully designed."
United States
Ryan
The price is P21,257
P24,020 total
includes taxes & fees
May 17 - May 18
Grand Bohemian Lodge Greenville, Autograph Collection

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (708 reviews)
"Excellent hotel"
United States
Brandon
The price is P10,279
P13,363 total
includes taxes & fees
May 11 - May 12
Hotel Hartness

The Westin Poinsett Greenville

The Westin Poinsett Greenville
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,000 reviews)
"Beautiful hotel, perfect location for walking downtown Greenville! Easy parking in attached garage, friendly staff!"
United States
Mary
The price is P16,337
P18,153 total
includes taxes & fees
May 10 - May 11
The Westin Poinsett Greenville

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (791 reviews)
"Great location great restaurant"
United States
Jennifer
The price is P12,086
P13,415 total
includes taxes & fees
May 10 - May 11
The Shepherd Hotel Downtown Clemson

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (815 reviews)
"Great spot"
United States
david
The price is P6,231
P6,854 total
includes taxes & fees
May 18 - May 19
Mint House Greenville Downtown by Kasa

Greenville Marriott

Greenville Marriott
4.0 star property
Greenville
8.6 out of 10, Excellent, (641 reviews)
"Awesome stay. Staff was super nice"
United States
Joshua
The price is P7,774
P8,833 total
includes taxes & fees
May 17 - May 18
Greenville Marriott

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (592 reviews)
"Amazing hotel, amazing location. Highly recommended. "
United States
Michele
The price is P9,237
P10,254 total
includes taxes & fees
May 11 - May 12
The Abernathy of Clemson

The Station by Compo Hotels

The Station by Compo Hotels
4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (19 reviews)
"Swamp rabbit trail and restaurants very close "
United States
Martin
The price is P15,023
P21,536 total
includes taxes & fees
Apr 27 - Apr 28
The Station by Compo Hotels

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (87 reviews)
"The was by far one of the best bed and breakfast places that I have ever stayed in. The house is beautiful, the rooms and spotless and the breakfast is amazing. "
United States
Jennifer Ann
The price is P7,177
P11,003 total
includes taxes & fees
May 10 - May 11
Liberty Hall Bed and Breakfast

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (33 reviews)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is P24,840
P27,324 total
includes taxes & fees
May 18 - May 19
Hotel Domestique

Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
4.0 star property
Greer
Landing Apartments Greer - Sugar Creek

Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
4.0 star property
Salem
Tee Times & Lake Days! Luxe Keowee Key Living

Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
4.0 star property
Salem
10.0 out of 10, Exceptional, (1 review)
"Property is in a great community, and it was very clean and beautifully decorated."
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!

Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
4.0 star property
Spartanburg
Landing Furnished Apartments - Spartanburg, SC

Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
4.0 star property
Salem
Private Balcony: Lake Keowee Home w/ Pool Access

Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
4.0 star property
Greenwood
10.0 out of 10, Exceptional, (2 reviews)
"Me and my family really enjoyed the property the view. Everything was nice. We really enjoyed it. Hopefully, we’ll be coming back soon."
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio

Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
4.0 star property
Salem
Views, Pools & Marina: Lake Keowee Condo!

Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
4.0 star property
Salem
Salem Vacation Rental w/ Lake Keowee Access!

5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
4.0 star property
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome

Park Place Apartments by Landing

Park Place Apartments by Landing
4.0 star property
Greenville
7.6 out of 10, Good, (46 reviews)
"Loved the apartment! Very spacious, clean, brand new. Access to bike paths. Seemed like a quirky location but everything is close by car or bike. "
United States
Kathie
Park Place Apartments by Landing
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

Photo by Ryan Watts
Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Explore a world of travel with Expedia