Default HTG hotel image

Santee Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 29 - Aug 30
Tomorrow
Aug 30 - Aug 31
Next weekend
Sep 4 - Sep 6
In two weeks
Sep 11 - Sep 13

Filter by

Star rating

Guest rating

Our top choices for Santee hotels

1. Lewis and Clark Resort

Lewis and Clark Resort
Yankton
United States
Melissa
P5,191
P5,486 total
includes taxes & fees
Aug 31 - Sep 1
Lewis and Clark Resort
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Santee Hotel Reviews

Lewis and Clark Resort

Lewis and Clark Resort

10/10 Excellent
"This condo was beautiful! Very clean and well maintained. Great location for everything we wanted to do in the Okoboji area. Would definitely stay here again."
Melissa 3-night trip
Posted 11 days ago
Lewis and Clark Resort

More cheap stays in Santee

Lewis and Clark Resort

Lewis and Clark Resort

43496 Shore Drive Yankton SD
P5,191
P5,486 total
Aug 31 - Sep 1
includes taxes & fees
9/10 Wonderful! (333 reviews)
Lewis and Clark Resort

Frequently asked questions

If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What is staying in Santee like?
Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 66 hotels and other accommodations in the surrounding area. Find out more about Santee.
What are the top places to visit in Santee?
A favorite place to visit is Lewis and Clark Lake. You'll also find Niobrara State Park and Lewis and Clark Recreation Area in the area. Check out what more to see and do in Expedia's Santee guide.
What's the weather like in Santee?
The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. The snowiest months in Santee are January, December, October, and March, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia