Santee Hotels

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 7 - Oct 8
Tomorrow
Oct 8 - Oct 9
This weekend
Oct 10 - Oct 12
Next weekend
Oct 17 - Oct 19

Filter by

Guest rating
Guest rating
Star rating

Top 10 trending Santee hotels

Lewis and Clark Resort
32-inch LCD TV with digital channels, TV

Lewis and Clark Resort

2.5 star property
8.8 out of 10, Excellent, (264)
"I stay here every two years. It's perfect for the price and any outdoorsmen."
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

More cheap stays in Santee

More cheap stays in Santee

Lewis and Clark Resort

Lewis and Clark Resort

43496 Shore Drive, Yankton, SD
Get rates
8.6/10 Excellent! (258 reviews)

Frequently asked questions

If I need to cancel my hotel reservation in Santee, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santee.

Where can I learn more about changing or cancelling my trip to Santee?

For more information about rescheduling or cancelling your trip to Santee, click here.

What is staying in Santee like?

Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 61 hotels and other accommodations in the surrounding area. Find out more about Santee.

What are the top places to visit in Santee?

A favorite place to visit is Lewis and Clark Lake. You'll also find Niobrara State Park and Lewis and Clark Recreation Area in the area. Check out what more to see and do in Expedia's Santee guide.

What's the weather like in Santee?

The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. The snowiest months in Santee are January, December, October, and March, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia

Explore a world of travel with Expedia