Santee Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Feb 26 - Feb 27
Tomorrow
Feb 27 - Feb 28
This weekend
Feb 27 - Mar 1
Next weekend
Mar 6 - Mar 8

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santee hotels

Living area

Lewis and Clark Resort

Lewis and Clark Resort
2.5 star property
Yankton
8.8 out of 10, Excellent, (292 reviews)
"Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!"
United States
Jessica
The price is P4,840
P5,116 total
includes taxes & fees
Mar 29 - Mar 30
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

Lewis and Clark Resort

Lewis and Clark Resort

10/10 Excellent
"Clean room. Beautiful location. Comfortable stay "
Lila 1-night trip
Posted 5 days ago
Lewis and Clark Resort

More cheap stays in Santee

Lewis and Clark Resort

Lewis and Clark Resort

43496 Shore Drive Yankton SD
The price is P4,840 per night from Mar 29 to Mar 30
P4,840
P5,116 total
Mar 29 - Mar 30
includes taxes & fees
8.8/10 Excellent! (292 reviews)

Frequently asked questions

If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What is staying in Santee like?
Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 60 hotels and other accommodations in the surrounding area. Find out more about Santee.
What are the top places to visit in Santee?
A favorite place to visit is Lewis and Clark Lake. You'll also find Niobrara State Park and Pebble Beach in the area. Check out what more to see and do in Expedia's Santee guide.
What's the weather like in Santee?
The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. The snowiest months in Santee are January, December, October, and March, with each month seeing an average of 8 inches of snowfall.

Explore a world of travel with Expedia