Luxury Hotels in Santa Cruz, O'Higgins Region

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Our top choices for Santa Cruz luxury hotels

Couples treatment rooms, hot springs, massages

Hotel Cava Colchagua

Hotel Cava Colchagua
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (175 reviews)
"Barrel rooms are comfortable."
Canada
Anonymous traveler
The price is P9,793
P9,793 total
May 29 - May 30
Hotel Cava Colchagua
Outdoor pool, sun loungers

Santa Cruz Plaza

Santa Cruz Plaza
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (360 reviews)
"spa, sauna and heated pool was nice touch"
Canada
sukhpreet
The price is P8,887
P8,887 total
May 31 - Jun 1
Santa Cruz Plaza
Separate tub and shower, deep soaking tub, free toiletries, hair dryer

Vik Chile

Vik Chile
5.0 star property
San Vicente
9.2 out of 10, Wonderful, (194 reviews)
  • cleanliness
    Relax amid wine country elegance at this San Vicente luxury hotel with 2 restaurants and a winery onsite.
"The rooms are quirky but very comfortable and spotless."
United States
Pamela
The price is P43,159
P43,159 total
May 27 - May 28
Vik Chile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santa Cruz Hotel Reviews

TerraViña

TerraViña

10/10 Excellent
"The hotel had a great buffet breakfast which was included with your stay. The staff were helpful and friendly would offer to book restaurant reservations. The only complaint was we found the air conditioner fan to loud."
Sharon 4-night trip
Posted 3 months ago
TerraViña

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz vacation?
During your visit, you might want to enjoy the tours which Santa Cruz is known for.
What's the best high-end place to stay in Santa Cruz?
Vibo Wine Lodge is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travelers looking for an elegant place to stay.
When can I expect good weather in Santa Cruz?
Planning for the weather is an important factor for making your trip to Santa Cruz a success, especially when you're splurging. The hottest months are usually January and February with an average temp of 70°F, while the coldest months are July and August with an average of 50°F. Average annual precipitation for Santa Cruz is 29 inches.
What's there to see and do in Santa Cruz?
Experience all that Santa Cruz has to offer when you visit Casino Colchagua, Colchagua Campo y Vino, and Lapostolle Clos Apalta Winery. If you have some spare time during your trip, you might want to check out Millahue Valley and Museo de Colchagua.