Hotels near Saint Francis Healthcare System

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Dec 25 - Dec 26
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Dec 26 - Dec 27
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Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Saint Francis Healthcare System hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
3.1 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is P5,285
P5,962 total
includes taxes & fees
Dec 30 - Dec 31
Drury Plaza Hotel Cape Girardeau Conference Center
Room
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (103)
"It was a nice stay"
United States
Douglas
The price is P5,249
P5,975 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Tru By Hilton Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
0.9 km from Saint Francis Healthcare System
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is P3,383
P3,816 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Quality Inn Cape Girardeau North
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
2.7 km from Saint Francis Healthcare System
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is P3,230
P3,774 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Town House Inn Cape Giradreau
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
3.7 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is P6,213
P7,009 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn Cape Girardeau I 55 East
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is P5,285
P5,962 total
includes taxes & fees
Dec 30 - Dec 31
Drury Inn & Suites Cape Girardeau
Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
4.1 km from Saint Francis Healthcare System
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is P8,826
P9,957 total
includes taxes & fees
Dec 28 - Dec 29
Rockwood Inn
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
3.6 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is P5,345
P6,029 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
5.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is P7,342
P8,319 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
4.7 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is P5,168
P5,831 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
3.4 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1002)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is P4,111
P4,637 total
includes taxes & fees
Dec 30 - Dec 31
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
5.3 km from Saint Francis Healthcare System
9.4 out of 10, Exceptional, (477)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is P5,656
P6,381 total
includes taxes & fees
Dec 28 - Dec 29
The Riverview
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
4.2 km from Saint Francis Healthcare System
8.8 out of 10, Excellent, (675)
"Great place "
United States
GUY
The price is P4,942
P5,349 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
4.2 km from Saint Francis Healthcare System
8.2 out of 10, Very Good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is P4,687
P5,072 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Jackson-Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
4.9 km from Saint Francis Healthcare System
8.2 out of 10, Very Good, (885)
"Room was clean and spacious."
United States
George
The price is P4,119
P4,971 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
12.3 km from Saint Francis Healthcare System
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is P4,874
P5,153 total
includes taxes & fees
Dec 28 - Dec 29
Drury Inn & Suites Jackson MO
Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
9.3 km from Saint Francis Healthcare System
7.6 out of 10, Good, (426)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is P4,123
P4,462 total
includes taxes & fees
Dec 28 - Dec 29
Town House Inn
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
3.5 km from Saint Francis Healthcare System
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is P4,111
P4,637 total
includes taxes & fees
Dec 30 - Dec 31
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Saint Francis Healthcare System Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"The room was great. Very clean and the bed was comfortable. "
Josh 1-night trip
Posted 4 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Hotels near other Saint Francis Healthcare System attractions

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Cape Splash Family Aquatic Center

Bring the family to Cape Splash Family Aquatic Center and enjoy this exciting amusement park in Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Saint Francis Healthcare System?
Saint Francis Healthcare System is located in Cape Girardeau. This family-friendly area is known for its array of dining options. You'll find 59 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay close to Saint Francis Healthcare System?
Quality Inn Cape Girardeau North is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.6 mi (0.9 km) from Saint Francis Healthcare System. Other good options within a few miles include Drury Plaza Hotel Cape Girardeau Conference Center and La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau.
How many hotels should I expect to find near Saint Francis Healthcare System?
Expedia has 59 hotels and other accommodations a few miles from Saint Francis Healthcare System.
If I need to cancel the hotel reservation for my stay near Saint Francis Healthcare System, will I receive a refund?
Yes, the majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals available near Saint Francis Healthcare System.
What can I see and do near Saint Francis Healthcare System?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center, and Lazy L Safari Park are fun stops for the whole family while you're in town. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.