Hotels near Isle Casino Cape Girardeau

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 24 - Dec 25
Tomorrow
Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Isle Casino Cape Girardeau hotels

Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
0.7 km from Isle Casino Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is P7,340
P8,318 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott Cape Girardeau Downtown
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
0.2 km from Isle Casino Cape Girardeau
9.4 out of 10, Exceptional, (476)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is P5,655
P6,380 total
includes taxes & fees
Dec 29 - Dec 30
The Riverview
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
3.1 km from Isle Casino Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is P3,237
P3,781 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Town House Inn Cape Giradreau
Lobby
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
1.3 km from Isle Casino Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is P8,844
P9,977 total
includes taxes & fees
Dec 28 - Dec 29
Rockwood Inn
Lobby
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
5.2 km from Isle Casino Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is P5,971
P6,736 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
5.5 km from Isle Casino Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is P5,296
P5,973 total
includes taxes & fees
Dec 29 - Dec 30
Drury Plaza Hotel Cape Girardeau Conference Center
Snack bar
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
8.3 km from Isle Casino Cape Girardeau
9.6 out of 10, Exceptional, (103)
"It was a nice stay"
United States
Douglas
The price is P5,260
P5,986 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tru By Hilton Cape Girardeau
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
5.3 km from Isle Casino Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is P5,344
P6,028 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
5.4 km from Isle Casino Cape Girardeau
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is P5,168
P5,830 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Free daily buffet breakfast
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
5.7 km from Isle Casino Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is P5,296
P5,973 total
includes taxes & fees
Dec 29 - Dec 30
Drury Inn & Suites Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
17 km from Isle Casino Cape Girardeau
9.6 out of 10, Exceptional, (1010)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is P4,884
P5,163 total
includes taxes & fees
Dec 28 - Dec 29
Drury Inn & Suites Jackson MO
Front of property
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
5.2 km from Isle Casino Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is P4,110
P4,637 total
includes taxes & fees
Dec 28 - Dec 29
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
9.5 km from Isle Casino Cape Girardeau
8.8 out of 10, Excellent, (674)
"Great place "
United States
GUY
The price is P4,952
P5,359 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
5.4 km from Isle Casino Cape Girardeau
8.2 out of 10, Very Good, (885)
"Room was clean and spacious."
United States
George
The price is P4,531
P5,435 total
includes taxes & fees
Jan 21 - Jan 22, 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
9.5 km from Isle Casino Cape Girardeau
8.2 out of 10, Very Good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is P4,696
P5,082 total
includes taxes & fees
Dec 28 - Dec 29
Comfort Suites Jackson-Cape Girardeau
Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
14.6 km from Isle Casino Cape Girardeau
7.6 out of 10, Good, (425)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is P4,131
P4,471 total
includes taxes & fees
Dec 25 - Dec 26
Town House Inn
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
6.2 km from Isle Casino Cape Girardeau
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is P3,382
P3,816 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Quality Inn Cape Girardeau North
Free daily buffet breakfast
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
5.6 km from Isle Casino Cape Girardeau
9.0 out of 10, Wonderful, (1000)
"Great stay"
United States
Heather
The price is P4,119
P4,646 total
includes taxes & fees
Dec 29 - Dec 30
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Isle Casino Cape Girardeau Hotel Reviews

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"Hotel was very clean, quiet and has a great location! "
Dustin 1-night trip
Posted 3 days ago
Tru By Hilton Cape Girardeau

Hotels near other Isle Casino Cape Girardeau attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Isle Casino Cape Girardeau?
Isle Casino Cape Girardeau is located in a family-friendly area of Cape Girardeau known for its array of dining options. If you're looking for a convenient place to stay, check out the 26 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Isle Casino Cape Girardeau?
Adjacent to Isle Casino Cape Girardeau, The Riverview is one of the top choices for your stay based on our traveler data, and this hotel offers a casino and 2 restaurants. Another good choice is Courtyard by Marriott Cape Girardeau Downtown, located just 0.4 mi (0.7 km) away.
How many hotels can I expect to find close to Isle Casino Cape Girardeau?
Expedia has 26 hotels and other accommodations within a mile from Isle Casino Cape Girardeau.
If I need to cancel the hotel reservation for my stay near Isle Casino Cape Girardeau, will I receive a refund?
Yes! The majority of room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review top deals close to Isle Casino Cape Girardeau.
What can I see and do near Isle Casino Cape Girardeau?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. If you're looking for something to do, plan a visit to Show Me Center, eDen Spa & Salon, and Devil's Island Wildlife Management Area while you're in the area.