Santa Cruz

Seville

A narrow cobblestone street lined with colorful buildings, shops, and a prominent white archway in the distance.
A historic plaza with ornate Gothic architecture, palm trees, and people walking.
A narrow street lined with trees and buildings, with people sitting at outdoor cafes.
A sunny urban square with tram tracks, historic buildings, and pedestrians.
A historic building with ornate columns, a large archway, and a statue.

Stay near popular Santa Cruz attractions

A courtyard with a central water feature, surrounded by columns and potted trees.

Royal Alcázar of Seville

9.6/10 (8,220 reviews)
Once a Moorish fort, this architectural gem is now the oldest functioning palace in Europe.
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Things to do

a narrow dirt road leading to a town in Spain

White Villages & Ronda Day Trip from Seville

P5,608
per adult
92% of travellers recommend
White Villages & Ronda Day Trip from Seville
Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

P2,584
per adult
88% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Three Cities in One Day: Córdoba, White Villages and Ronda from Sevilla

Three Cities in One Day: Córdoba, White Villages and Ronda from Sevilla

P7,808
per adult
94% of travellers recommend
Three Cities in One Day: Córdoba, White Villages and Ronda from Sevilla
Seville: Casa de la Memoria Flamenco Show

Seville: Casa de la Memoria Flamenco Show

P1,704
per adult
100% of travellers recommend
Seville: Casa de la Memoria Flamenco Show
Landscape of Guadalquivir river area with several buildings in view.

Guadalquivir River Criuse Tour

P1,335
per adult
80% of travellers recommend
Guadalquivir River Criuse Tour
Small-Group Alcazar of Seville Guided Tour with entry ticket

Small Group Alcazar of Seville Guided Tour with Fast Track Ticket

P3,884
per adult
98% of travellers recommend
Small Group Alcazar of Seville Guided Tour with Fast Track Ticket
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Top hotels in Santa Cruz

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
The price is P7,079 per night from Dec 1 to Dec 2
P7,079
P7,786 total
Dec 1 - Dec 2
includes taxes & fees
Book a stay at this spa hotel in Seville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,027 reviews)
"great location and everythikng else"

Reviewed on Nov 1, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
The price is P8,830 per night from Nov 22 to Nov 23
P8,830
P9,713 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this boutique hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
9.6/10 Exceptional! (1,301 reviews)
"Beautiful historic building in the heart of Barrio Santa Cruz. The music theme is well done throughout. Gorgeous decor with a modern touch. Room was spacious, clean, with all the modern appointments. For the location and modern charm you can’t beat this hotel."

Reviewed on Nov 3, 2026

Hotel Amadeus Sevilla
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
The price is P34,573 per night from Dec 2 to Dec 3
P34,573
P38,031 total
Dec 2 - Dec 3
includes taxes & fees
Book a stay at this luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our ...
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
The price is P8,323 per night from Nov 30 to Dec 1
P8,323
P9,156 total
Nov 30 - Dec 1
includes taxes & fees
Book a stay at this business-friendly hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool ...
Hotel Fernando III
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
The price is P8,323 per night from Dec 1 to Dec 2
P8,323
P9,156 total
Dec 1 - Dec 2
includes taxes & fees
Stay at this hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular ...
Hotel Rey Alfonso X
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
The price is P6,033 per night from Nov 29 to Nov 30
P6,033
P6,637 total
Nov 29 - Nov 30
includes taxes & fees
Book a stay at this family-friendly hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (1,108 reviews)
"The hotel was amazing. Beautiful and architecturally amazing. The location is perfect, near to all the attractions. The only challenge is getting there as you can't reach it by car. There is a 2 min walk to get the hotel and you have to bring your luggage by foot, but it is totally worth it. There ..."

Reviewed on Nov 1, 2026

Hotel Murillo
See all 411 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.
A bustling urban street lined with historic buildings and trees.

Historical Center

Casa de la Memoria Cultural Center and Calle Sierpes are a few top attractions in Historical Center. Hop around the city on the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out the area's fantastic nightlife, stunning cathedral, and popular shops.

A river with boats, a historic tower, and a cityscape with trees and buildings.

El Arenal

Travelers choose El Arenal for its ample dining options. Hop aboard the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out top sights like Teatro Maestranza.

A modern architectural structure with a unique, wave-like design.
Photo by Daniel Villafruela.
Open Photo by Daniel Villafruela.

Alfalfa

Unique features of Alfalfa include the bars and historic sites. Make a stop by Calle Sierpes or Casa de la Memoria Cultural Center while you're exploring the area.

A large, illuminated bridge with circular arches over a calm river.

Triana

Known for its abundant dining options and stunning river views, there's plenty to explore in Triana. Top attractions like Triana Market and Triana Bridge are major draws, and you can catch the metro at Plaza de Cuba Station or Cartuja Station to see more of the city.

A modern stadium with a unique curved roof structure, surrounded by urban buildings and a prominent tower in the background.
Photo by Filippo Arena
Open Photo by Filippo Arena

San Bartolomé

Travelers come to San Bartolomé for its lively bars, and you can see top attractions like Pilate's House and Zurbarán Statue while you're in town.

Santa Cruz