Otay Mesa Hotels near San Diego

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Check prices for these dates

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Nov 10 - Nov 11
Tomorrow
Nov 11 - Nov 12
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,962 reviews)
"Good place to stay for work."
United States
Renato
The price is P9,079
P10,327 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A hotel room with a kitchenette, dining area, and a ceiling fan.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,004 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveler
The price is P6,872
P7,817 total
includes taxes & fees
Nov 22 - Nov 23
Quality Suites San Diego Otay Mesa
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

3. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,030 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is P10,770
P11,868 total
includes taxes & fees
Nov 29 - Nov 30
Ayres Hotel San Diego South - Chula Vista
A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

4. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,050 reviews)
"Me and my husband loved it we tried different ones and this one is one of the best from now on is going to be our favorite to stay,very clean and breakfast was so good so many options for breakfast"
United States
Edna
The price is P6,913
P7,618 total
includes taxes & fees
Nov 22 - Nov 23
Best Western Chula Vista/Otay Valley Hotel
A compact hotel room with a kitchenette, a bed, a small seating area, and a window providing natural light.

5. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,657 reviews)
"Great stay"
United States
Daniel
The price is P10,067
P11,074 total
includes taxes & fees
Dec 8 - Dec 9
Holiday Inn Express San Diego South - Chula Vista by IHG
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,733 reviews)
"It was a nice hotel. I’d stay here again."
United States
Lori
The price is P6,841
P7,538 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn Chula Vista San Diego South
A hotel room with two beds, a television, a desk, and a dresser.

7. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,800 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is P6,592
P7,251 total
includes taxes & fees
Nov 22 - Nov 23
La Quinta Inn by Wyndham San Diego Chula Vista
View from property

8. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (822 reviews)
"Great hotel"
United States
leslie
The price is P13,014
P14,341 total
includes taxes & fees
Nov 19 - Nov 20
SpringHill Suites by Marriott Chula Vista Eastlake
A modern living room with a large window, a fireplace, and a kitchen area.

9. Rodeway Inn San Diego South San Ysidro Border

Rodeway Inn San Diego South San Ysidro Border
2.0 star property
5.8 km from Otay Mesa
8.0 out of 10, Very good, (322 reviews)
"Great service beautiful hotel"
United States
Guadalupe
The price is P4,766
P5,422 total
includes taxes & fees
Nov 23 - Nov 24
Rodeway Inn San Diego South San Ysidro Border
A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

10. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,234 reviews)
"Clean room and really nice area for our stay"
United States
Brandon
The price is P8,455
P9,317 total
includes taxes & fees
Nov 29 - Nov 30
Best Western Plus Marina Gateway Hotel
A motel with a sign indicating amenities like Wi-Fi, TV, and pool.

11. Valli Hi Motel

Valli Hi Motel
2.0 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,170 reviews)
"Clean rooms and nice staff"
United States
Wendy
The price is P5,129
P5,844 total
includes taxes & fees
Nov 11 - Nov 12
Valli Hi Motel
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

12. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,584 reviews)
"Really nice place"
United States
justin
The price is P7,049
P7,767 total
includes taxes & fees
Nov 18 - Nov 19
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

13. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,213 reviews)
"Solid place to stay"
United States
Neal
The price is P5,866
P6,787 total
includes taxes & fees
Dec 1 - Dec 2
The Rambler Hotel
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

14. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,428 reviews)
"Great service from the staff!"
United States
Erika
The price is P6,602
P7,510 total
includes taxes & fees
Nov 22 - Nov 23
Best Western Americana Inn
A swimming pool with palm trees and a mountain in the background.

15. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,222 reviews)
"Great stay!"
United States
Kimberly
The price is P5,759
P7,094 total
includes taxes & fees
Nov 16 - Nov 17
Sycuan Casino Resort
A high-rise building complex with multiple floors, large windows, and a waterfront view.

16. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 24.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,896 reviews)
"Beautiful hotel would stay again!"
United States
Petra
The price is P9,639
P14,611 total
includes taxes & fees
Dec 11 - Dec 12
Manchester Grand Hyatt San Diego
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

17. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,464 reviews)
"Clean rooms nice staff"
United States
Wendy
The price is P4,077
P4,484 total
includes taxes & fees
Nov 11 - Nov 12
Hotel Palmeras Chula Vista
An outdoor seating area with a fire feature, string lights, and a view of the city skyline.

18. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
17.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,168 reviews)
"Lovely place to stay, beautiful scenery. The only downside is everything is far away- gas station, restaurants, you have to UBER or have a rental car to travel for amenities outside of what the resort offers."
United States
Josh
The price is P12,324
P17,038 total
includes taxes & fees
Nov 30 - Dec 1
Loews Coronado Bay Resort
A hotel room with two beds, a desk, and a chair.

19. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,194 reviews)
"Great stay for a stay !"
United States
Monserrat
The price is P4,555
P5,019 total
includes taxes & fees
Nov 23 - Nov 24
Howard Johnson by Wyndham National City/San Diego South
A modern outdoor fire feature with a glass enclosure, surrounded by a white wall.

20. Holiday Inn Express & Suites San Diego - Mission Valley by IHG

Holiday Inn Express & Suites San Diego - Mission Valley by IHG
2.5 star property
28.8 km from Otay Mesa
8.8 out of 10, Excellent, (1,009 reviews)
"Breakfast included. Staff are very helpful."
United States
Rosita
The price is P7,914
P9,295 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites San Diego - Mission Valley by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
8.4
Very good
1,962 reviews
View
A hotel room with a kitchenette, dining area, and a ceiling fan.
Quality Suites San Diego Otay Mesa
2.5 star property
7.2
Good
1,004 reviews
View
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,030 reviews
View
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,428 reviews
View
View from property
SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
9.6
Exceptional
822 reviews
View

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Frequently Asked Questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.