Otay Mesa Hotels, San Diego

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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Rafael

P10,019 total

includes taxes & fees

Aug 17 - Aug 18

2. Quality Suites San Diego Otay Mesa

Otay Mesa

Michael A

P8,337 total

includes taxes & fees

Aug 2 - Aug 3

3. Ayres Hotel San Diego South - Chula Vista

6.5 km from Otay Mesa

Deniece

P14,477 total

includes taxes & fees

Aug 16 - Aug 17

4. Best Western Americana Inn

8 km from Otay Mesa

Amir

P8,765 total

includes taxes & fees

Aug 2 - Aug 3

Premium bedding, in-room safe, desk, laptop workspace

5. Best Western Plus Marina Gateway Hotel

16.9 km from Otay Mesa

Abdelghani

P11,546 total

includes taxes & fees

Aug 16 - Aug 17

6. Comfort Inn Chula Vista San Diego South

13 km from Otay Mesa

Francisco

P8,596 total

includes taxes & fees

Aug 17 - Aug 18

7. La Quinta Inn by Wyndham San Diego Chula Vista

12.9 km from Otay Mesa

Lidia

P8,005 total

includes taxes & fees

Aug 9 - Aug 10

8. Holiday Inn Express San Diego South - Chula Vista by IHG

14.5 km from Otay Mesa

P9,944 total

includes taxes & fees

Aug 20 - Aug 21

Premium bedding, desk, blackout drapes, soundproofing

9. Valli Hi Motel

7.9 km from Otay Mesa

AILEEN

P6,317 total

includes taxes & fees

Jul 27 - Jul 28

10. Hercor Hotel - Urban Boutique

13.6 km from Otay Mesa

Leopoldo

P7,421 total

includes taxes & fees

Aug 2 - Aug 3

11. SureStay Hotel by Best Western Chula Vista San Diego Bay

14.7 km from Otay Mesa

Chris

P5,437 total

includes taxes & fees

Aug 16 - Aug 17

Desk, blackout drapes, iron/ironing board (on request), WiFi (free)

12. Hotel Palmeras Chula Vista

14.4 km from Otay Mesa

ERICK GUADALUPE

P5,335 total

includes taxes & fees

Aug 2 - Aug 3

13. The Rambler Hotel

14.8 km from Otay Mesa

Jennifer

P9,549 total

includes taxes & fees

Aug 16 - Aug 17

14. Best Western Chula Vista/Otay Valley Hotel

7.1 km from Otay Mesa

vanessa

P8,019 total

includes taxes & fees

Aug 16 - Aug 17

15. Loews Coronado Bay Resort

17.2 km from Otay Mesa

Shawna

P22,190 total

includes taxes & fees

Aug 10 - Aug 11

16. Best Western Plus La Mesa San Diego

24.6 km from Otay Mesa

Eric

P10,596 total

includes taxes & fees

Aug 2 - Aug 3

Desk, blackout drapes, WiFi (free), bed sheets

17. Hotel Milagro

14.9 km from Otay Mesa

Mary

P5,570 total

includes taxes & fees

Aug 2 - Aug 3

18. Hampton Inn & Suites San Diego Airport Liberty Station

29.2 km from Otay Mesa

Edward

P12,275 total

includes taxes & fees

Aug 3 - Aug 4

19. Lamplighter Inn & Suites at SDSU

24.4 km from Otay Mesa

Bernadette

P11,962 total

includes taxes & fees

Aug 17 - Aug 18

20. Motel 6 El Cajon, CA - San Diego

27 km from Otay Mesa

Jhonny

P5,307 total

includes taxes & fees

Aug 16 - Aug 17

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

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A beach with surfers and swimmers during sunset.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

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Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

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Top Otay Mesa Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

8/10 Good

"Left chargers in the room and got them back from the staff after they found them."

Loews Coronado Bay Resort

10/10 Excellent

"Just an amazing overall experience. The resort was top notch! Staff was friendly and professional and went out of their way to greet you with a pleasant "good morning" or "good afternoon". We did not walk past a staff member without a positive interaction. Room was clean and the pool area was fantastic. Great food and rinks poolside with plenty of wait staff to assist with orders. The front desk staff was EXCELLENT! I highly recommend and we'll be back to this resort next time we visit San Diego/Coronado."

Wyndham Garden San Diego Near SeaWorld

10/10 Excellent

"7/19/26 We only stayed 1 night, but overall, we'd stay there again. Rooms and property were as clean as they should be. Staff were amicable. Plenty of dining options within walking distance, or a very short drive. There is a Panera onsite. Pool looked clean. The only issue we ran into was that the 2 ice makers, nearest to our room, were out of order, but it wasn't a make or break for us."

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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Otay Mesa Hotels near San Diego

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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2. Quality Suites San Diego Otay Mesa

3. Ayres Hotel San Diego South - Chula Vista

4. Best Western Americana Inn

5. Best Western Plus Marina Gateway Hotel

6. Comfort Inn Chula Vista San Diego South

7. La Quinta Inn by Wyndham San Diego Chula Vista

8. Holiday Inn Express San Diego South - Chula Vista by IHG

9. Valli Hi Motel

10. Hercor Hotel - Urban Boutique

11. SureStay Hotel by Best Western Chula Vista San Diego Bay

12. Hotel Palmeras Chula Vista

13. The Rambler Hotel

14. Best Western Chula Vista/Otay Valley Hotel

15. Loews Coronado Bay Resort

16. Best Western Plus La Mesa San Diego

17. Hotel Milagro

18. Hampton Inn & Suites San Diego Airport Liberty Station

19. Lamplighter Inn & Suites at SDSU

20. Motel 6 El Cajon, CA - San Diego

Where to stay in Otay Mesa

Downtown San Diego

Pacific Beach

Mission Beach

Gaslamp Quarter

Mission Bay

Top Otay Mesa Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Frequently asked questions

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