Top 10 Hotels Near Louisville Science Center in Louisville for 2026

The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

1. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from Louisville Science Center

Casey

P11,409

P13,242 total

includes taxes & fees

Sep 29 - Sep 30

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

2. Hotel Distil, Autograph Collection

Downtown Louisville, 0.9 km from Louisville Science Center

Adam

P15,377

P18,093 total

includes taxes & fees

Oct 4 - Oct 5

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, large windows, and classic furniture.

3. The Brown Hotel

Downtown Louisville, 1.2 km from Louisville Science Center

Melanie

P8,878

P10,446 total

includes taxes & fees

Sep 28 - Sep 29

A modern bar area with a circular bar, multiple seating options, and a large screen.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from Louisville Science Center

Cinda

P6,083

P7,157 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

5. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2.1 km from Louisville Science Center

Maria

P7,663

P9,016 total

includes taxes & fees

Oct 4 - Oct 5

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.2 km from Louisville Science Center

Diane

P7,613

P8,957 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

7. Stellar Suites

East Market District, 2.2 km from Louisville Science Center

Benton

P6,158

P10,419 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A building with a sign reading "THE GRADY" at the entrance.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A modern restaurant interior with a staircase, round tables, and a brick wall.

8. The Grady

Downtown Louisville, 0.2 km from Louisville Science Center

Bruce

P10,945

P12,878 total

includes taxes & fees

Oct 11 - Oct 12

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

9. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from Louisville Science Center

Matt

P11,126

P13,404 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

10. Omni Louisville Hotel

Downtown Louisville, 0.8 km from Louisville Science Center

Gilbert

P17,487

P20,575 total

includes taxes & fees

Oct 13 - Oct 14

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from Louisville Science Center

Cameron

P13,302

P15,651 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor seating area with wicker furniture and a fire pit.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

12. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from Louisville Science Center

Scott

P6,889

P8,106 total

includes taxes & fees

Oct 25 - Oct 26

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

13. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Bryan

P8,017

P9,433 total

includes taxes & fees

Oct 11 - Oct 12

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

14. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from Louisville Science Center

Angela

P8,213

P9,663 total

includes taxes & fees

Oct 4 - Oct 5

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

15. AC Hotel Louisville Downtown

East Market District, 2.1 km from Louisville Science Center

Jen

P8,963

P10,545 total

includes taxes & fees

Oct 4 - Oct 5

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A garden pathway with a lantern, potted plants, and a white fence.

16. Central Park Bed & Breakfast

Old Louisville, 3 km from Louisville Science Center

Angie

P10,696

P12,415 total

includes taxes & fees

Sep 29 - Sep 30

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A balcony with a view of a river, a bridge, and a cityscape.

17. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from Louisville Science Center

Saud

P9,420

P11,083 total

includes taxes & fees

Oct 25 - Oct 26

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A brightly lit grocery store with yellow shelving and a central checkout counter.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A bedroom with a bed, a chair, a TV, and a window with curtains.

18. Hotel Genevieve part of JdV by Hyatt

East Market District, 2.1 km from Louisville Science Center

Rebekah

P9,520

P11,201 total

includes taxes & fees

Oct 4 - Oct 5

A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.

A reception area with marble counters, modern pendant lighting, and potted orchids.

A modern bar area with glass partitions, bar stools, and a variety of bottles.

A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.

19. Louisville Marriott Downtown

Downtown Louisville, 0.8 km from Louisville Science Center

Jacobi

P13,412

P15,780 total

includes taxes & fees

Oct 4 - Oct 5

A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.

A hotel room with two beds, a wooden headboard, bedside lamps, a small table, and a patterned rug.

A modern lobby with a curved seating area, a red ottoman, and a television screen.

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.2 km from Louisville Science Center

Carlos

P6,200

P7,295 total

includes taxes & fees

Oct 25 - Oct 26

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Compare popular hotels close to Louisville Science Center

Property	Property class	Guest rating
DuPont Mansion Bed & Breakfast	9.6 Exceptional 147 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 505 reviews	View
The Brown Hotel	9.4 Exceptional 1,321 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,011 reviews	View
Tempo By Hilton Louisville Downtown Nulu	9.4 Exceptional 1,124 reviews	View

Top Louisville Science Center Hotel Reviews

Omni Louisville Hotel

10/10 Excellent

"Extremely nice property downtown close to the KFC arena."

Hyatt Regency Louisville

10/10 Excellent

"Clean rooms, good room service, amazing on site restaraunt and bar. In door pool is kinda small but clean"

The Grady

10/10 Excellent

"Nice place. Fantastic location. Next to major distilleries and bars."

Moxy Louisville Downtown

8/10 Good

"No way to get hot water for tea for guests."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Super easy to walk to a bunch of distilleries and also get to great restaurants and speakeasies."

Louisville Marriott Downtown

10/10 Excellent

"It was completely comfortable"

21c Museum Hotel Louisville

10/10 Excellent

"It was a great stay! The room and location were perfect, and the staff were very accommodating!"

SpringHill Suites by Marriott Louisville Downtown

10/10 Excellent

"Our room was clean and spacious. The staff were nice and helpful."

Other attractions near Louisville Science Center

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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The Frazier History Museum with red doors and a tree in front.

Frazier International History Museum

9.4/10 (10 reviews)

Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's lively festivals or attend a sporting event.

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Frequently asked questions

What's the area like around Louisville Science Center?

Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Louisville Science Center?

Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.

How many hotels can I expect to find close to Louisville Science Center?

Expedia has 292 hotels and other accommodations within a mile from Louisville Science Center.

If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.

What can I see and do near Louisville Science Center?

21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

Hotels near Louisville Science Center

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Our top choices for Louisville Science Center hotels

1. DuPont Mansion Bed & Breakfast

2. Hotel Distil, Autograph Collection

3. The Brown Hotel

4. Cambria Hotel Louisville Downtown-Whiskey Row

5. Tempo By Hilton Louisville Downtown Nulu

6. Homewood Suites by Hilton Louisville Downtown, KY

7. Stellar Suites

8. The Grady

9. 21c Museum Hotel Louisville

10. Omni Louisville Hotel

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

12. Towneplace Suites By Marriott Louisville Downtown

13. Moxy Louisville Downtown

14. Aloft by Marriott Louisville Downtown

15. AC Hotel Louisville Downtown

16. Central Park Bed & Breakfast

17. Galt House Hotel Trademark Collection by Wyndham

18. Hotel Genevieve part of JdV by Hyatt

19. Louisville Marriott Downtown

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Compare popular hotels close to Louisville Science Center

Top Louisville Science Center Hotel Reviews

Omni Louisville Hotel

Hyatt Regency Louisville

The Grady

Moxy Louisville Downtown

Aloft by Marriott Louisville Downtown

Louisville Marriott Downtown

21c Museum Hotel Louisville

SpringHill Suites by Marriott Louisville Downtown

Other attractions near Louisville Science Center

Louisville Slugger Museum

Muhammad Ali Center

Frazier International History Museum

Kentucky Center for the Performing Arts

Kentucky Museum of Art and Craft

Golden Statue of David

SAR Genealogical Research Library: NSSAR Library

Louisville Glassworks

Frequently asked questions