Uptown - Upper Duval

Key West

Key West Butterfly and Nature Conservatory featuring flowers, animals and zoo animals
Key West Butterfly and Nature Conservatory showing animals, zoo animals and flowers
South Beach featuring a coastal town and a beach as well as a large group of people
South Beach featuring a luxury hotel or resort, swimming and a sandy beach
Key West Butterfly and Nature Conservatory featuring signage

Popular places to visit

Southernmost Point

Southernmost Point

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach

South Beach

The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.

South Beach
Key West Butterfly and Nature Conservatory showing zoo animals, animals and food

Key West Butterfly and Nature Conservatory

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

P811
per traveler
78% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
Bahama Village Walking Tour

Bahama Village Walking Tour

P1,685
per adult
Bahama Village Walking Tour
Key West’s Old Town Treasures: A Self-Guided Audio Tour

Key West’s Old Town Treasures: A Self-Guided Audio Tour

P842
per adult
Key West’s Old Town Treasures: A Self-Guided Audio Tour
Florida Key West Self-Guided Walking Audio Tour

Florida Key West Self-Guided Walking Audio Tour Via App

P477
per traveler
Florida Key West Self-Guided Walking Audio Tour Via App
Climb the 88 stairs to the top of the Key West Lighthouse.

Maritime Village to Micro State: A Self Guided Tour of Key West

P674
per adult
Maritime Village to Micro State: A Self Guided Tour of Key West
Key West History And Culture Walking Tour

Southernmost Key West History and Culture Small-Group Walking Tour

P2,247
per adult
Southernmost Key West History and Culture Small-Group Walking Tour
See all activities in Key West

Top hotels in Uptown - Upper Duval

Southernmost Beach Resort and Guesthouses
Southernmost Beach Resort and Guesthouses
4 out of 5
1319 Duval Street, Key West, FL
The price is P12,932 per night from Jul 14 to Jul 15
P12,932
per night
Jul 14 - Jul 15
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,567 reviews)
"The front desk was great. We had a couple set backs as far our room. And we were over charged."

Reviewed on Jun 27, 2025

Southernmost Beach Resort and Guesthouses
The Reach Key West, Curio Collection by Hilton
The Reach Key West, Curio Collection by Hilton
4 out of 5
1435 Simonton Street, Key West, FL
The price is P12,475 per night from Jul 8 to Jul 9
P12,475
per night
Jul 8 - Jul 9
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.2/10 Very Good! (999 reviews)
"The staff was very nice. The restaurant at the hotel offered food with impeccable taste."

Reviewed on Jun 25, 2025

The Reach Key West, Curio Collection by Hilton
The Southernmost Inn - Adults Only
The Southernmost Inn - Adults Only
3 out of 5
525 United Street, Key West, FL
The price is P10,692 per night from Jul 7 to Jul 8
P10,692
per night
Jul 7 - Jul 8
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8/10 Very Good! (1,101 reviews)
"Really nice property, excellent value, friendly staff, great area"

Reviewed on Jun 25, 2025

The Southernmost Inn - Adults Only
Orchid Key Inn - Adults Only
Orchid Key Inn - Adults Only
3.5 out of 5
1004 Duval St, Key West, FL
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
9.8/10 Exceptional! (1,005 reviews)
"We were on our honeymoon and booked this hotel for three days in Key West. They allowed us to check in 2 hours earlier and even upgraded us to their largest suite! The best thing was we didn’t mention we were on honeymoon and they upgraded us, and they even gave us free drinks at the bar. They did ..."

Reviewed on Jun 27, 2025

Get rates
Orchid Key Inn - Adults Only
Southernmost House
Southernmost House
4 out of 5
1400 Duval Street, Key West, FL
The price is P10,129 per night from Jul 9 to Jul 10
P10,129
per night
Jul 9 - Jul 10
Stay at this 4-star beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (998 reviews)
"Beautiful, romantic location right on the water. Infinity pool overlooking the Gulf. We stayed in Bungalow 103 which was right next to the pool and had a view of the ocean. Room was great with kitchen and walk in shower. We will be back!!"

Reviewed on Jun 21, 2025

Southernmost House
Southwinds Motel
Southwinds Motel
2 out of 5
1321 Simonton Street, Key West, FL
The price is P8,723 per night from Jun 30 to Jul 1
P8,723
per night
Jun 30 - Jul 1
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,118 reviews)
"Was very clean, air conditioner worked very well, pool was good, but closed pretty early. Great value considering its one of the cheaper places in Kwy West. Will definitely be staying there for our next trip."

Reviewed on Jun 25, 2025

Southwinds Motel
See all 2,802 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Uptown - Upper Duval

Key West Historic District

Old Town Key West

If you're spending some time in Old Town Key West, Duval Street and Saint Mary Star of the Sea are top sights worth seeing.

Old Town Key West
Key West featuring a marina, a coastal town and general coastal views

Downtown Key West

If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.

Downtown Key West
Harry S. Truman Little White House which includes a house and cycling

Bahama Village

Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
Clarence S. Higgs Memorial Beach Park which includes landscape views, tropical scenes and a sandy beach

Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
Audubon House and Tropical Gardens featuring a house

Key West Historic District

Travelers to Key West Historic District praise its fantastic nightlife. If you've got some more time to explore, be sure to make a stop by Duval Street and Saint Mary Star of the Sea.

Key West Historic District
Great location for great pictures, very nice beach

White Street Gallery District

When in White Street Gallery District, you can plan a visit to Duval Street and Saint Mary Star of the Sea, some noteworthy sights in the nearby area.

White Street Gallery District

Uptown - Upper Duval