Uptown - Upper Duval

Key West

Key West Butterfly and Nature Conservatory featuring flowers, animals and zoo animals
Key West Butterfly and Nature Conservatory showing animals, zoo animals and flowers
South Beach featuring a coastal town and a beach as well as a large group of people
South Beach featuring a luxury hotel or resort, swimming and a sandy beach
Key West Butterfly and Nature Conservatory featuring signage

Popular places to visit

Southernmost Point

Southernmost Point

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach

South Beach

The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.

South Beach
Key West Butterfly and Nature Conservatory showing zoo animals, animals and food

Key West Butterfly and Nature Conservatory

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

P988
per traveler
78% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
Bahama Village Walking Tour

Bahama Village Walking Tour

P1,745
per adult
Bahama Village Walking Tour
Key West’s Old Town Treasures: A Self-Guided Audio Tour

Key West’s Old Town Treasures: A Self-Guided Audio Tour

P872
per adult
Key West’s Old Town Treasures: A Self-Guided Audio Tour
Florida Key West Self-Guided Walking Audio Tour

Florida Key West Self-Guided Walking Audio Tour Via App

P581
per traveler
Florida Key West Self-Guided Walking Audio Tour Via App
Climb the 88 stairs to the top of the Key West Lighthouse.

Maritime Village to Micro State: A Self Guided Tour of Key West

P697
per adult
Maritime Village to Micro State: A Self Guided Tour of Key West
An Audio Guide of Key West’s Journey From Village to Micro State

An Audio Guide of Key West’s Journey From Village to Micro State

P697
per adult
An Audio Guide of Key West’s Journey From Village to Micro State
See all activities in Key West

Top hotels in Uptown - Upper Duval

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street, Key West, FL
The price is P9,671 per night from Aug 27 to Aug 28
P9,671
P14,733 total
Aug 27 - Aug 28
includes taxes & fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,677 reviews)
"Property is nice, horrible smell around via the rotting sea weed on the beach. If you like walking round wifh a beer in hand browsing shops then this is a great location as it is at the start of Duval street. Lots of food options about. Would not call this or any other destinations on the island ..."

Reviewed on Aug 13, 2025

Southernmost Beach Resort and Guesthouses
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street, Key West, FL
The price is P13,560 per night from Aug 24 to Aug 25
P13,560
P18,680 total
Aug 24 - Aug 25
includes taxes & fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,007 reviews)
Tropical paradise within your Reach
"Staff friendly and so accommodating! My wife somewhat particular about view from room; Phiwe and her colleague guided us to the perfect room overlooking pool and, a few feet beyond, the sandy beach. Lots of extras and you are able to walk over to sister property Casa Marina and hang out there too. ..."

Reviewed on Aug 10, 2025

The Reach Key West, Curio Collection by Hilton
Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street, Key West, FL
The price is P7,101 per night from Aug 17 to Aug 18
P7,101
P9,585 total
Aug 17 - Aug 18
includes taxes & fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,153 reviews)
"Great location, nice rooms, the staff is super friendly & provides a great vacation experience."

Reviewed on Aug 11, 2025

Southwinds Motel
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

3 out of 5
525 United Street, Key West, FL
The price is P5,618 per night from Aug 19 to Aug 20
P5,618
P8,873 total
Aug 19 - Aug 20
includes taxes & fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,150 reviews)
"I love the continental breakfast and the cheese and wine happy hour. It makes paying $40 a night for a resort fee less painful. I also liked that they did not charge an incidental fee assuming you’re gonna trash the hotel room. In fact, most hotels I stayed at while in Key West. Don’t collect both. ..."

Reviewed on Aug 10, 2025

The Southernmost Inn - Adults Only
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

3.5 out of 5
1004 Duval St, Key West, FL
The price is P12,873 per night from Aug 20 to Aug 21
P12,873
P14,482 total
Aug 20 - Aug 21
includes taxes & fees
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
9.8/10 Exceptional! (1,005 reviews)
"Excellent friendly staff and beautiful property."

Reviewed on Aug 10, 2025

Orchid Key Inn - Adults Only
Southernmost House

Southernmost House

4 out of 5
1400 Duval Street, Key West, FL
The price is P10,396 per night from Aug 28 to Aug 29
P10,396
P16,963 total
Aug 28 - Aug 29
includes taxes & fees
Stay at this 4-star beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,002 reviews)
"The mansion is beautiful very historic. The staff were so nice and welcoming. We really didn't have to leave the grounds for anything, will be back again!"

Reviewed on Aug 9, 2025

Southernmost House
See all 2,773 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Uptown - Upper Duval

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Old Town Key West

If you're spending some time in Old Town Key West, Duval Street and Saint Mary Star of the Sea are top sights worth seeing.

Old Town Key West
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Downtown Key West

If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.

Downtown Key West
Harry S. Truman Little White House showing a house and cycling

Bahama Village

Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
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Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
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Key West Historic District

Travelers to Key West Historic District praise its fantastic nightlife. If you've got some more time to explore, be sure to make a stop by Duval Street and Saint Mary Star of the Sea.

Key West Historic District
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White Street Gallery District

When in White Street Gallery District, you can plan a visit to Duval Street and Saint Mary Star of the Sea, some noteworthy sights in the nearby area.

White Street Gallery District

Uptown - Upper Duval