South Main Hotels near Houston

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Our top choices for South Main hotels

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1004)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is P5,136
P6,009 total
includes taxes & fees
Dec 22 - Dec 23
Comfort Suites Houston near Medical Center- NRG Stadium

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1004)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is P3,270
P3,826 total
includes taxes & fees
Dec 28 - Dec 29
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (988)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is P4,076
P4,769 total
includes taxes & fees
Dec 16 - Dec 17
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1197)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is P5,258
P6,151 total
includes taxes & fees
Dec 22 - Dec 23
Wyndham Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (823)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is P4,135
P4,838 total
includes taxes & fees
Dec 22 - Dec 23
Candlewood Suites Houston Medical Center by IHG

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very Good, (3946)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is P4,694
P5,492 total
includes taxes & fees
Dec 27 - Dec 28
Club Quarters Hotel Downtown, Houston

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1708)
"Nice hotel, the staff was very friendly "
United States
Debra
The price is P5,104
P6,003 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1602)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is P8,084
P9,577 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hilton Americas-Houston

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31 km from South Main
8.2 out of 10, Very Good, (1016)
"Room was clean, staff friendly "
United States
Jessica
The price is P4,395
P5,170 total
includes taxes & fees
Dec 20 - Dec 21
Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX
3.0 star property
15 km from South Main
8.8 out of 10, Excellent, (1009)
"Staff was great and ver helpful. Food was amazing and I would stay there again."
United States
Arlyne
The price is P4,139
P4,843 total
includes taxes & fees
Dec 22 - Dec 23
Hilton Garden Inn Houston Hobby Airport, TX

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1077)
"Great place to stay "
United States
Hammed Sirleau
The price is P5,975
P6,991 total
includes taxes & fees
Dec 26 - Dec 27
Courtyard by Marriott Houston Intercontinental Airport

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1013)
"Location and cleanliness were wonderful "
United States
Cory
The price is P3,716
P4,348 total
includes taxes & fees
Dec 18 - Dec 19
Platinum Inn & Suites Webster

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1005)
"The staff was super nice and the location worked great for us! "
Mexico
Valeria
The price is P4,442
P5,198 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Tru by Hilton Houston Webster NASA

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1614)
"The rooms have been excellent each time I come in town and stay there. "
United States
Dalmon
The price is P5,473
P6,404 total
includes taxes & fees
Dec 19 - Dec 20
SpringHill Suites by Marriott Houston Intercontinental Arprt

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1267)
"The breakfast was phenomenal and everything was clean"
United States
Pablo
The price is P5,494
P6,467 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Place Houston/Galleria

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very Good, (1466)
"Wonderful hotel!"
United States
Debbie
The price is P6,569
P7,686 total
includes taxes & fees
Dec 19 - Dec 20
The Royal Sonesta Houston Galleria

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1173)
"Staff was very courteous, Vallet was super helpful and nice, and room was excellent. Hotel was beautifully decorated for holidays. "
United States
Coleen
The price is P6,498
P9,399 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Regency Houston/Galleria

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
4.4 km from South Main
8.4 out of 10, Very Good, (1755)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is P5,222
P6,179 total
includes taxes & fees
Dec 22 - Dec 23
Hilton Houston Plaza/Medical Center

Hampton Inn Houston Downtown

Hampton Inn Houston Downtown
2.5 star property
10.8 km from South Main
8.8 out of 10, Excellent, (1004)
"Clean rooms and nice staff! They were very accommodating for our event with late check out! "
United States
Gwen
The price is P6,097
P7,133 total
includes taxes & fees
Dec 23 - Dec 24
Hampton Inn Houston Downtown

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very Good, (1190)
"Nice, comfortable room by airport"
United States
Douglas
The price is P4,055
P4,744 total
includes taxes & fees
Dec 18 - Dec 19
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Top South Main Hotel Reviews

Find out more about South Main

Top reasons to visit South Main

  • Cultural Hub: South Main features a vibrant blend of historic and modern universities, art museums, and cultural events, enriching the experience for visitors.
  • Entertainment Options: Enjoy music concerts, movie showings, and various campus events that cater to diverse interests.
  • Convenient Location: Its proximity to downtown Houston makes South Main an ideal base for exploring local attractions.
  • Dynamic Sports Scene: Engage in numerous sports activities, with notable venues like Stockton Arena and Ballpark.
  • Diverse Accommodations: Choose from a wide range of hotels and aparthotels, ensuring a comfortable stay for all types of travellers.

Find great hotels near South Main

South Main, Houston, offers a diverse selection of accommodations, including both hotels and aparthotels, catering to various traveller needs. With a focus on business amenities, pet-friendly options, and an inclusive atmosphere for the LGBTQIA community, visitors can enjoy a welcoming and comfortable stay. Whether you're searching for the best hotels or top choices in Stockton, South Main provides a remarkable array of lodging to enhance your holiday experience.

  • Club Quarters Hotel Downtown, Houston: This 4-star hotel embodies a blend of modern convenience and a vibrant shopping atmosphere, making it ideal for business travellers and pet owners alike. Located 11.3km from South Main, it features a welcoming pet policy that includes free amenities for furry companions. Guests can enjoy the convenience of being in a bustling shopping district while benefiting from amenities such as food and water bowls for pets, ensuring a comfortable stay for all members of the family. The hotel's focus on business travel is evident in its well-equipped facilities, catering to those who need to balance work and play.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: Situated 8.0km from South Main, this 4-star hotel is the epitome of family-friendly hospitality with a special emphasis on inclusivity for the LGBTQIA community. The hotel offers a warm and welcoming atmosphere, complemented by thoughtful amenities for children, including cribs and window guards. Guests love the signature DoubleTree chocolate chip cookie upon arrival, adding a delightful touch to their stay. The proximity to the Galleria's shopping and dining options makes it a prime choice for families seeking both comfort and convenience.
  • The Royal Sonesta Houston Galleria: Just 8.0km from South Main, this 4-star hotel is perfect for those who appreciate a luxurious shopping experience combined with pet-friendly policies. The Royal Sonesta offers a sophisticated atmosphere with amenities tailored to both business and leisure travellers. Its pet policy includes restrictions to ensure a pleasant stay for all guests while offering the convenience of being located in a vibrant shopping district. Guests are particularly fond of the elegant rooms and attentive service, making it a top choice for those seeking a stylish escape.

Where to stay near South Main

Visitors to South Main, Houston, will discover a vibrant mix of culture and urban charm. This neighbourhood boasts a convenient location near downtown, making it an ideal base for exploring local attractions. Enjoy family-friendly activities, experience the bustling atmosphere of Main Street, and indulge in the dynamic sports scene. With its friendly people and rich cultural experiences, South Main promises a memorable getaway that caters to both business and leisure travellers alike.

  • Houston: As a vibrant metropolis, Houston serves as the heart of South Main. This bustling city is a hub for family-oriented activities, business ventures, and entertainment experiences. With visitor numbers peaking in March, May, and July, Houston offers a dynamic atmosphere enriched with shopping centres, music concerts, and lively sports stadiums. Explore local landmarks such as the event conference venues and convention centres, which host a variety of attractions throughout the year, ensuring a memorable travel experience.
  • Texas Medical Center: Located a mere 3.2km from South Main, the Texas Medical Center is a distinguished neighbourhood renowned for its focus on business, culture, and education. Visitors flock here mainly in April, July, and September, drawn by its modern college universities and cutting-edge research facilities. The area boasts an array of shopping malls and centres, making it a convenient spot to combine leisure with learning. The nearby sports stadium adds an extra layer of excitement for sports enthusiasts.
  • Willow Meadows/Willowbend Area: Also situated 3.2km from South Main, the Willow Meadows/Willowbend Area invites travellers seeking a mix of business, sports, and city experiences. With peak visitation in March, May, and July, this neighbourhood is perfect for enjoying shopping centres, music concerts, and vibrant community events. Local landmarks, including sports facilities and modern educational institutions, contribute to the area's charm, making it a delightful destination for both relaxation and exploration.

Things to do near South Main

South Main offers a delightful mix of activities for sports enthusiasts and culture seekers alike. Enjoy educational opportunities, music concerts, and vibrant shopping experiences at the local mall centre. Be sure to catch movie showings and engage in various campus events, all set against the backdrop of Houston's dynamic atmosphere. Whether you're in the mood for entertainment or learning, South Main has something to offer every visitor.

Shopping

Experience shopping in South Main with nearby gems like The Galleria, 8.0km away, offering a vibrant mix of entertainment and family-friendly vibes. Also, visit River Oaks District, a public market just 8.0km away, where you’ll find a blend of city and business atmospheres for unique gifts.

Recreation

At the nearby NRG Astrodome, immerse yourself in the exhilarating atmosphere of live sports events. Experience the upscale charm of the Houston Polo Club, where you can indulge in luxury while enjoying polo matches. The Toyota Center offers a vibrant sports environment, perfect for an energetic outing.

Adventure

Experience the thrill of free-fall at iFLY Indoor Skydiving, located 16.1km from South Main. For family fun, visit Chancellors Family Center, 8.0km away, which offers various adventure activities. Also, enjoy a spirited game at Homer Ford Tennis Center, situated 8.0km from South Main.

Nightlife

The nightlife in South Main offers a delightful mix. Enjoy a romantic show at Main Street Theater, or catch a family-friendly film at Regal Edwards Greenway Grand Palace. For a bit of fun, head to Zuma Fun Center for arcade adventures that the whole family will enjoy.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for South Main

To save on your trip to South Main, consider visiting in August or December to January when accommodation prices are lower. Sundays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to filter for eco-friendly hotels and sort by price to find the best deals. Additionally, book a package deal that combines flights, accommodation, and activities for added savings. Explore free attractions in the area and utilise public transport for an economical way to get around, ensuring a budget-friendly experience.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to customise your preferences, such as your budget, preferred location, and the type of hotel you desire. For instance, selecting the Eco-certified filter will showcase sustainable and eco-friendly accommodation options currently available. To find the most affordable prices and best deals, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your South Main hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near South Main

South Main in Houston, Texas, offers a diverse range of activities ideal for sports enthusiasts, business travellers, and culture seekers alike. Visitors can explore historic and modern universities, as well as art museums, providing enriching experiences for families and culture lovers. Notable attractions include Stockton Arena and Stockton Ballpark, along with various nearby points of interest, ensuring a memorable stay for all who venture to this vibrant area.

  • Lakewood Church: Experience the vibrant atmosphere of Lakewood Church, known for its uplifting services and community spirit. This expansive venue, located 6.4km from South Main, hosts inspiring events and concerts, making it a cultural hub for visitors and locals alike.
  • Houston Baptist University: Discover the modern architecture and lively environment of Houston Baptist University, situated 9.7km from South Main. This institution boasts a diverse student body and offers various events, providing a genuine city vibe that reflects the heart of Houston.
  • Houston Center for Photography: Immerse yourself in the artistic world at the Houston Center for Photography, located 8.0km from South Main. This venue showcases stunning photographic exhibitions and workshops, celebrating creativity and culture in a welcoming setting.

Best time to go to South Main

The best time to visit South Main is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

Travelling to South Main, Houston, is convenient with three major airports nearby. Houston, TX (IAH-George Bush Intercontinental) is situated 35.4km away, offering excellent hotels like the DoubleTree by Hilton Houston Intercontinental Airport, 4.8km from the airport, and the Houston Airport Marriott at George Bush Intercontinental, which is located on-site. Alternatively, Houston, TX (HOU-William P. Hobby) is 14.5km away, with luxurious options such as the JW Marriott Houston Downtown. Lastly, Houston, TX (EFD-Ellington Field) lies 25.7km from South Main, featuring hotels like the Doubletree by Hilton Houston Hobby Airport, 11.3km from the airport. Each airport provides efficient transportation services to their respective hotels.

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Frequently asked questions

What is South Main like?
You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness center. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels will I be able to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighborhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.