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Our top choices for Santa Cruz hotels

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (347)
"Great spacious property with nice pool!"
United States
Douglas
The price is P7,612
P7,612 total
Jan 4 - Jan 5, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (211)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is P6,531
P6,531 total
Jan 2 - Jan 3, 2026
Marriott Santa Cruz de la Sierra Hotel

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (77)
"Great Spot"
United States
Jose
The price is P2,284
P2,284 total
Dec 27 - Dec 28
Ibis Santa Cruz DE LA Sierra

Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (331)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is P5,265
P5,265 total
Dec 27 - Dec 28
Sun Hotel

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (408)
"The parrots. Unique"
United States
Juan P
The price is P10,572
P10,572 total
Dec 26 - Dec 27
Camino Real Hotel

Hotel Cortez

Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (124)
"The staff and property are second to none! "
United States
Cynthia
The price is P8,087
P8,087 total
Jan 11 - Jan 12, 2026
Hotel Cortez

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (104)
"Luxurious hotel,very chic and beautiful."
United States
Cristhian
The price is P5,873
P5,873 total
Jan 12 - Jan 13, 2026
Novotel Santa Cruz De La Sierra

HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (36)
"Hot tub worked well and room was very comfortable! 24 hr market across the street came in handy. The best hotel I've stayed at in Bolivia!"
United States
Robert
HOTEL OSHO

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (256)
"Nice hotel "
United States
Narciso Lorenzo
The price is P5,403
P5,403 total
Dec 28 - Dec 29
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz

Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (48)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is P2,291
P2,291 total
Dec 26 - Dec 27
Premium Suites Deluxe Aparthotel Equipetrol

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is P5,227
P5,227 total
Dec 26 - Dec 27
TRYP by Wyndham Santa Cruz

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (82)
"Beautiful hotel"
Australia
Joanna
The price is P8,692
P8,692 total
Jan 9 - Jan 10, 2026
Swissôtel Santa Cruz De La Sierra

Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (73)
"Excellent place to stay!"
United States
Luisa
The price is P2,867
P2,867 total
Dec 30 - Dec 31
Delfines Collection Hotel By Mercure

Lido Hotel

Lido Hotel
3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is P2,080
P2,080 total
Dec 26 - Dec 27
Lido Hotel

Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (40)
"Love it. Will stay again!!"
United States
Juan
The price is P6,223
P6,223 total
Jan 6 - Jan 7, 2026
Alfonsina Hotel Boutique by Inboccaluppo

Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro
3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (281)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro

Hotel LP Equipetrol

Hotel LP Equipetrol
3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol

Hotel Las Américas

Hotel Las Américas
3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is P2,257
P2,257 total
Dec 26 - Dec 27
Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Showing deals for:Jan 2 - Jan 4
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Top Santa Cruz Hotel Reviews

Guide to exploring Santa Cruz

Top reasons to visit Santa Cruz

  • Vibrant Markets: Explore colourful markets offering local crafts, fresh produce, and Bolivian delicacies.
  • National Parks: Discover stunning national parks perfect for hiking and wildlife watching.
  • Cultural Experiences: Enjoy enriching activities, including opera performances and traditional ceremonies.
  • Sports Enthusiasm: Witness thrilling soccer matches that showcase local passion for the sport.
  • Diverse Accommodation: Choose from luxurious hotels to budget-friendly hostels catering to all traveller needs.

Find great hotels in Santa Cruz

Discover the diverse accommodation options in Santa Cruz, Bolivia, where you can find everything from luxurious hotels to budget-friendly hostels. Whether you’re seeking a family getaway, a pet-friendly retreat, or business travel amenities, Santa Cruz hotels cater to all your needs. With a variety of star-rated options, you’re sure to find the perfect place to unwind after exploring this vibrant city.

  • Marriott Santa Cruz de la Sierra Hotel: This luxurious 5-star hotel is a sanctuary for both business and leisure travellers. With its sleek design and modern amenities, Marriott Santa Cruz de la Sierra caters to families as well, offering a range of child-friendly services, including free cribs. Guests can unwind at the full-service spa or take a refreshing dip in the outdoor pool, complete with sun loungers. The on-site spa features daily treatments and massage services, ensuring relaxation is at the forefront of your stay. This hotel seamlessly combines professional comforts with family-friendly features, making it an ideal choice for a well-rounded vacation experience.
  • Camino Real Hotel: As a distinguished 4-star establishment, Camino Real Hotel presents a warm and inviting atmosphere perfect for families and business travellers alike. This hotel is equipped with amenities designed specifically for children, including a shared playground and an onsite babysitting service for a nominal fee. Families can enjoy the children’s pool, ensuring a delightful experience for younger guests. The hotel’s commitment to providing a comfortable stay for both adults and children makes it an excellent option for those seeking a family-centric vacation in Santa Cruz.
  • Radisson Hotel Santa Cruz: A hallmark of luxury and inclusivity, the 5-star Radisson Hotel Santa Cruz welcomes all travellers, including the LGBTQIA community. This vibrant hotel is an ideal retreat for families, featuring amenities such as a trampoline and free supervised childcare, making it particularly family-friendly. The modern design and high-end services create a memorable atmosphere, while its affiliation with LGBTQI travel guides ensures an inclusive experience for all guests. With a focus on comfort and community, this hotel is perfect for those looking to enjoy the best of Santa Cruz.

Where to stay in Santa Cruz

Santa Cruz, Bolivia, offers an enchanting blend of vibrant city life and tropical relaxation, perfect for families and sports enthusiasts alike. Explore stylish getaways with stunning city views and beautiful beaches, all while enjoying the friendly atmosphere. Whether you seek thrilling excursions or a tranquil retreat, Santa Cruz promises an unforgettable experience that caters to every traveller's needs, making it an ideal destination for your vacation.

  • Santa Cruz: As the largest city in Bolivia, Santa Cruz is a vibrant metropolis known for its dynamic culture and modern amenities. Nestled in the eastern lowlands, it serves as a gateway to the lush Amazon rainforest. Travellers flock here for its diverse offerings, which include extensive shopping centres, cinemas, and a lively dining scene. The city's rich history is showcased in landmarks like the stunning cathedral and the picturesque piazza square. With peak visitor numbers in January, July, and September, Santa Cruz is an ideal destination for family and cultural experiences.
  • Samaipata: Located a short drive from Santa Cruz, Samaipata is a charming town that captivates visitors with its breathtaking natural scenery and outdoor adventures. This destination is perfect for those seeking hiking trails and stunning landscapes that showcase Bolivia's diverse geography. The local market offers a taste of traditional Bolivian culture, while the archaeological site and museum provide insights into the region's rich history. With peak arrivals in January, July, and September, Samaipata is an outdoor enthusiast's paradise that promises unforgettable adventures.
  • Montero: Montero is a bustling city situated to the north of Santa Cruz, known for its family-friendly atmosphere and business opportunities. This urban area features modern shopping centres and malls, making it a convenient stop for retail therapy. The city experiences a peak in visitor numbers from January and during the September to October period. Montero's close proximity to Santa Cruz makes it an accessible destination for those looking to explore Bolivian city life while enjoying a more laid-back environment.

Things to do in Santa Cruz

Santa Cruz offers a delightful blend of city-themed adventures, family-friendly activities, and sports events. Visitors can explore vibrant markets, enjoy thrilling soccer matches, and indulge in cultural experiences like the opera. This dynamic city caters to diverse interests, ensuring a memorable holiday for everyone.

Shopping

In Santa Cruz, visit Patio Design LifeStyle Center for a blend of family and business vibes, or head to Ventura Mall for entertainment and shopping. Don't miss La Recova Artisan Walk, where you can find unique artisan gifts in a vibrant atmosphere.

Recreation

Experience the energetic atmosphere at Ramon Tahuichi Aguilera Stadium, where you can enjoy various sports activities. Engage in recreational events or simply soak in the vibrant sports culture. The stadium is an excellent spot to feel the local spirit while staying active during your visit to Santa Cruz.

Adventure

In Santa Cruz, explore the Amboró National Park, a paradise for hiking enthusiasts with diverse flora and fauna. Experience the thrill of zip-lining in the lush canopy or embark on an exhilarating mountain biking adventure through rugged trails, immersing yourself in the breathtaking Bolivian landscape.

Nightlife

Experience the vibrant nightlife in Santa Cruz by visiting Casa Municipal de Cultura Raúl Otero Reiche for captivating performances and cultural events. For a family-friendly outing, enjoy a film at Cine Center, where you can indulge in a cinematic experience filled with entertainment and romance.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Cruz

To save money on your trip to Santa Cruz, visit during the cheaper months of January, June, and August. Saturdays usually offer the best accommodation rates, while Tuesdays are the priciest. Use Expedia’s search tool to filter your preferences and sort results from lowest to highest price. Consider booking a package that combines your hotel, flights, and activities for additional savings. Look for hotel deals, compare room rates, and remain flexible with your booking to snag last-minute bargains.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Cruz are January, June and August, where the prices are slightly lower. This is in comparison to March, September and December, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Cruz is Saturday. The most expensive day to stay in Santa Cruz is Tuesday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, including your budget, desired location, and the type of accommodation you favour. To discover the most affordable prices and offers, arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can potentially save money by combining your Santa Cruz hotel reservation with your flights and activities through an Expedia package.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, offers a diverse vacation experience suitable for families, sports enthusiasts, and cultural travellers alike. Explore its captivating national parks, stunning cathedrals, and iconic landmarks, all while indulging in outdoor and adventure activities. Whether you're seeking cultural immersion or thrilling experiences, the Santa Cruz area has something for everyone, ensuring a memorable holiday for all types of visitors.

  • Univalle: Experience the vibrant academic atmosphere at Univalle, an esteemed educational institution in Santa Cruz. The campus is infused with cultural vibes, showcasing local art and fostering an environment of creativity and learning.
  • Santa Cruz de la Sierra Contemporary Art Museum: Immerse yourself in the rich artistic heritage at this contemporary art museum. Located in the heart of Santa Cruz, it features innovative exhibitions and installations that reflect the dynamic cultural landscape of the region.
  • Parque Ecológico: Enjoy the tranquillity of nature at Parque Ecológico, an urban park perfect for families. With lush greenery and recreational areas, it's an ideal spot for leisurely strolls or picnics amidst the vibrant city life.

Best time to go to Santa Cruz

The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.3°F (25.700000000000003°C)Light RainMostly SunnySlightly LowSlightly Low
February77.0°F (25.0°C)Light RainMostly CloudySlightly HighAverage
March76.5°F (24.700000000000003°C)Light RainMostly SunnyAverageSlightly High
April74.5°F (23.6°C)Light RainMostly SunnyAverageAverage
May70.2°F (21.200000000000003°C)Light RainMostly SunnySlightly LowAverage
June67.8°F (19.9°C)Light RainMostly SunnyAverageSlightly Low
July68.5°F (20.3°C)No RainMostly SunnyAverageAverage
August72.9°F (22.700000000000003°C)No RainSunnySlightly HighSlightly Low
September77.9°F (25.5°C)Light RainSunnySlightly HighSlightly High
October79.5°F (26.4°C)Light RainMostly SunnyAverageAverage
November79.3°F (26.3°C)Light RainMostly SunnyAverageAverage
December78.4°F (25.8°C)Light RainMostly SunnySlightly LowSlightly High

The nearest major airports for your trip to Santa Cruz

When visiting Santa Cruz, Bolivia, you can fly into Viru Viru International Airport (VVI), situated 16.1km from the city centre. Nearby, you'll find excellent accommodation options such as the 5-star Marriott Santa Cruz de la Sierra Hotel and Radisson Hotel Santa Cruz, both approximately 14.5km away, as well as the 4-star Camino Real Hotel, located 12.9km from the airport. For those considering Potosi, Captain Nicolas Rojas Airport (POI) is 331.5km away, with hotels like Hotel Santa Monica and Hostal La Casona offering airport shuttle services within 6.4km of Potosi.

Frequently asked questions

How much do hotels in Santa Cruz cost?
The season and factors like school holidays, Christmas and Easter can influence the price of a hotel in Santa Cruz. You can find cheap options from P2,080 in a few different ways on Expedia. First, key in the dates you'd like to go on vacation, then use the filters such as property type and amenities to refine your search. You can also sort by price, so the most inexpensive options appear at the top.
When is the best time to go to Santa Cruz?
If you're thinking of visiting in summer, reserve your Santa Cruz hotel between December and February. Temperatures during the summer here range from 22ºC to 31ºC. Santa Cruz has an oceanic climate, so pack appropriately.
Are there any luxury hotels in Santa Cruz?
Expedia has got some terrific stays for an indulgent escape in Santa Cruz, Santa Cruz, such as Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Check in and make use of amenities like concierge services, a garden and complimentary breakfast. Alternatively, treat yourself at Radisson Hotel Santa Cruz.
What are the top all-inclusive hotels in Santa Cruz?
If you're looking for a relaxed and worry-free escape, throw your bags down at Prince Hotel. Generally including your drinks, food and some recreational activities in the flat upfront rate, it's one of the best options for an all-inclusive retreat in Santa Cruz.
How can I find cheap hotels in Santa Cruz?
Discover inexpensive hotels with minimal effort by making use of our filter tool. Choose the "Price per night" box to view low-cost options in Santa Cruz. Another way is to take a look at our cheap hotels in Santa Cruz page. The lowest price available starts from P2,080 per night.
What are the best hotels in Santa Cruz for families?
Cosmopolitano Hotel Boutique is one of the top-rated hotels for families, located in Santa Cruz, Santa Cruz. Book here and take advantage of conveniences such as complimentary breakfast and a cafe. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is another favorite where kiddos are welcome. For more hotel options, fine-tune your search results by selecting "Family friendly" under the "Traveler experience" filter heading.
Why should I book my Santa Cruz hotel with Expedia?
Book your Santa Cruz hotel with Expedia and enjoy a world of options at unbeatable prices. Use our search filters to help you find exactly what you want, whether that's a 5-star escape or something a little more unique, like a houseboat, log cabin or villa! Join Expedia Rewards and you'll save 10% or more on over 100,000 hotels worldwide when you're signed in. Collect points on eligible bookings, which you can use to save on your next epic adventure. Plus, many of our hotels come with flexible cancellation policies, so you can rest easy if your plans happen to change.