Santa Cruz Trips

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    Save up to P 3,118 when you book a flight and hotel together*

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Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is P2,548 per night from Jan 21 to Jan 22
P2,548
P2,548 total
Jan 21 - Jan 22
9.4/10 Exceptional! (82 reviews)
Loved the fact we could check in early for a minimal fee. Staff were nice. The room was good but a bit stuffy and the air conditioning unit had a lot of dirt and dust in it. There was also a weird smell that they sprayed that was a bit nauseating. Otherwise the hotel had a great vibe and was decorated ...

Reviewed on Jan 13, 2026

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is P5,791 per night from Feb 11 to Feb 12
P5,791
P5,791 total
Feb 11 - Feb 12
9/10 Wonderful! (213 reviews)
Muy bien exelente

Reviewed on Dec 9, 2025

Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is P7,516 per night from Jan 30 to Jan 31
P7,516
P7,516 total
Jan 30 - Jan 31
8.8/10 Excellent! (350 reviews)
everything

Reviewed on Jan 6, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
See all 306 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
We make it simple to travel the world, with Santa Cruz vacation packages starting from as little as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cozy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz vacation?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favorite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz vacation package is the most convenient way to organize your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz vacation package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

Popular places to visit

Guembe Biocenter

Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.

Guembe Biocenter

Lomas de Arena Regional Park

Explore the great outdoors at Lomas de Arena Regional Park, a lovely green space in Santa Cruz. While in the area, you can find time to visit its shops.

Lomas de Arena Regional Park

What to do in Santa Cruz

Wildlife rescue center and preservation park

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

P5,003
per adult
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande

Guided visit to the Che Guevara Memorial in Vallegrande

P1,118
per adult
Guided visit to the Che Guevara Memorial in Vallegrande
Vallegrande City

Vallegrande City Tour

P1,707
per adult
Vallegrande City Tour
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.