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Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.
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Charleston

Charleston
A tree-lined landscape with a river and fields.
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East Prairie

East Prairie

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Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

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Our top choices for Mississippi County hotels

A building with a fountain and flower beds in front.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is P4,229
P4,734 total
includes taxes & fees
Oct 29 - Oct 30
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (680 reviews)
"Breakfast was light but good"
United States
zandra
The price is P3,784
P4,238 total
includes taxes & fees
Oct 28 - Oct 29
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is P4,197
P4,699 total
includes taxes & fees
Oct 28 - Oct 29
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is P4,402
P4,886 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels recommended for families in Mississippi County

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,003)
The price is P5,978
P6,873 total
includes taxes & fees
Nov 1 - Nov 2
Drury Inn & Suites Sikeston, MO
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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

8/10 Good
"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."
Byron E. Shryock 1-night trip
Posted 15 hours ago
Drury Inn & Suites Sikeston, MO