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Business Hotels in Central San Diego, San Diego

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Check availability on Central San Diego Business Hotels

Our top choices for Central San Diego business-friendly hotels

A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

1. Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
Kearny Mesa
9.2 out of 10, Wonderful, (1,012 reviews)
"Fantastic hotel with very friendly staff"
United States
Jeffrey
The price is P6,889
P7,905 total
includes taxes & fees
Dec 11 - Dec 12
Hampton Inn San Diego-Kearny Mesa
An outdoor patio with wicker furniture, a grill, and string lights.

2. TownePlace Suites by Marriott San Diego Central

TownePlace Suites by Marriott San Diego Central
3.0 star property
Kearny Mesa
9.0 out of 10, Wonderful, (645 reviews)
"Great hotel all around!"
United States
Eduardo
The price is P10,767
P12,376 total
includes taxes & fees
Dec 11 - Dec 12
TownePlace Suites by Marriott San Diego Central
A modern bar area with wooden ceiling beams, bar stools, and a long counter.

3. Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
Kearny Mesa
8.8 out of 10, Excellent, (1,007 reviews)
"Great staff, clean rooms and excellent location"
United States
Ahmad
The price is P8,496
P9,765 total
includes taxes & fees
Nov 23 - Nov 24
Courtyard by Marriott San Diego Central
A spacious lobby with a high ceiling, modern furniture, and a fireplace.

4. Four Points by Sheraton San Diego

Four Points by Sheraton San Diego
3.5 star property
Kearny Mesa
8.4 out of 10, Very good, (1,004 reviews)
"Wonderful Weekend, hotel was nice and clean."
United States
Lucy
The price is P8,511
P9,784 total
includes taxes & fees
Nov 23 - Nov 24
Four Points by Sheraton San Diego
A modern hotel with a glass entrance, outdoor seating, and palm trees.

5. Hilton Garden Inn San Diego Mission Valley Stadium

Hilton Garden Inn San Diego Mission Valley Stadium
3.0 star property
Kearny Mesa
8.0 out of 10, Very good, (1,013 reviews)
"Overall, our stay was great!"
United States
Willy
The price is P7,771
P8,932 total
includes taxes & fees
Nov 22 - Nov 23
Hilton Garden Inn San Diego Mission Valley Stadium
Room

6. Extended Stay America Suites San Diego Mission Valley Stadium

Extended Stay America Suites San Diego Mission Valley Stadium
2.5 star property
Kearny Mesa
6.6 out of 10, (1,003 reviews)
"Room was clean, staff was great and its in a convenient location."
United States
Brenda
The price is P6,528
P7,504 total
includes taxes & fees
Nov 17 - Nov 18
Extended Stay America Suites San Diego Mission Valley Stadium
A bar area with a glass ceiling, a central bar counter, and multiple stools.

7. Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (2,140 reviews)
"Beautiful hotel with wonderful staff! I have already booked my next stay. I would highly recommend this hotel."
United States
Heather
The price is P17,212
P19,784 total
includes taxes & fees
Nov 16 - Nov 17
Lafayette Hotel & Club
A hotel entrance with a stone archway, a reception desk, and potted plants.

8. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1,104 reviews)
"Great family hotel. Simple and clean yummy breakfast inexpensive and perfect for our short stay in sd"
United States
Alejandra
The price is P8,611
P9,898 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express San Diego Airport - Old Town by IHG
An outdoor seating area with a fire feature, white chairs, and potted plants.

9. Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
Mission Valley
9.2 out of 10, Wonderful, (1,002 reviews)
"Lovely stay, definitely will be back!"
United States
Kaliyah
The price is P10,025
P11,523 total
includes taxes & fees
Nov 11 - Nov 12
Springhill Suites San Diego Mission Valley
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

10. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (243 reviews)
"Location is great because it is so close to the airport and you won’t even be able to hear the planes. The room is so roomy and has every utility you need !"
United States
Stephanie
The price is P7,331
P10,410 total
includes taxes & fees
Dec 2 - Dec 3
City24 Hotel Little Italy Mission Hills
An outdoor patio with wicker furniture, a stone fire pit, and blue umbrellas.

11. HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
Sorrento Valley
9.2 out of 10, Wonderful, (1,008 reviews)
"Overall great location, staff, and room"
United States
Melissa
The price is P9,687
P11,135 total
includes taxes & fees
Nov 15 - Nov 16
HYATT house San Diego/Sorrento Mesa
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.

12. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (3,106 reviews)
"We really enjoyed our stay. The pool was great and really enjoyed the bar and staff"
United States
Kathy
The price is P11,462
P13,175 total
includes taxes & fees
Nov 12 - Nov 13
Legacy Resort Hotel & Spa
A living room with a sectional sofa, a wooden coffee table, a blue ottoman, a wooden chair with cushions, a built-in bookshelf, and a stone wall with a fireplace.

13. Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
Sorrento Valley
9.0 out of 10, Wonderful, (1,766 reviews)
"Had a great stay!"
United States
Terrance
The price is P8,521
P9,794 total
includes taxes & fees
Nov 22 - Nov 23
Country Inn & Suites by Radisson, San Diego North, CA
A spacious lobby with a central seating area, a reception desk, and a staircase leading to an upper level.

14. Courtyard by Marriott San Diego Miramar

Courtyard by Marriott San Diego Miramar
3.0 star property
Miramar
8.8 out of 10, Excellent, (1,002 reviews)
"Decent Hotel"
United States
Jignesh
The price is P9,057
P10,410 total
includes taxes & fees
Nov 23 - Nov 24
Courtyard by Marriott San Diego Miramar
An outdoor seating area with a pergola, tables, and chairs, and a sign welcoming to the Cosmopolitan Restaurant.

15. Cosmopolitan Hotel & Restaurant

Cosmopolitan Hotel & Restaurant
2.5 star property
Old Town San Diego
9.2 out of 10, Wonderful, (773 reviews)
"Great atmosphere! Perfect place to enjoy all of Old town San Diego"
United States
Alan
The price is P12,599
P14,206 total
includes taxes & fees
Nov 11 - Nov 12
Cosmopolitan Hotel & Restaurant
An outdoor seating area with sofas, a fire pit, and umbrellas.

16. Homewood Suites by Hilton San Diego Central

Homewood Suites by Hilton San Diego Central
3.0 star property
Scripps Ranch
8.6 out of 10, Excellent, (1,001 reviews)
"Great accommodation"
United States
FERDNAND GERARD
The price is P7,985
P9,178 total
includes taxes & fees
Nov 22 - Nov 23
Homewood Suites by Hilton San Diego Central
A swimming pool with lounge chairs and a waterfall feature, surrounded by palm trees and a building with multiple balconies.

17. San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
Mission Valley
8.8 out of 10, Excellent, (1,016 reviews)
"The trolley that's just across the street from the hotel was amazing and convenient!"
United States
Eva
The price is P10,025
P11,523 total
includes taxes & fees
Nov 15 - Nov 16
San Diego Marriott Mission Valley
Room

18. Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG
2.5 star property
Sorrento Valley
8.8 out of 10, Excellent, (1,001 reviews)
"Perfect for business stays…"
United States
Jesus
The price is P9,394
P10,798 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG
A poolside area with lounge chairs, a fire pit, and string lights.

19. Hyatt Regency La Jolla

Hyatt Regency La Jolla
4.0 star property
University City
9.0 out of 10, Wonderful, (1,003 reviews)
"Grace was amazing! She helped so much and was so sweet!! Can’t wait to go back and stay there again!"
United States
Priya
The price is P12,808
P17,047 total
includes taxes & fees
Nov 20 - Nov 21
Hyatt Regency La Jolla
A modern lobby with a stone wall, blue sofas, a reception desk, and a staircase.

20. Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3,852 reviews)
"Loved this hotel and will be back!"
United States
james
The price is P4,872
P5,591 total
includes taxes & fees
Dec 10 - Dec 11
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Handlery Hotel

Handlery Hotel

10/10 Excellent
"This property had such a cool, vintage California feel. Even though it is an old building, things were well kept up and clean. The beds were comfortable and I was glad the room had a coffee maker and a safe. The restaurant on site was good and all employees I interacted with were friendly. Parking was a bit pricey at $24 a day, but that’s really my only complaint. I would stay here again."
Kimberly Sarah 3-night trip
Posted 1 hour ago
Handlery Hotel

Frequently asked questions

Why book your business-friendly hotel in Central San Diego with Expedia?
Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From meeting rooms and conference spaces to on-site restaurants and more, our accommodations have all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Central San Diego?
Click on the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Central San Diego. Then fine-tune your search by your nightly budget. Looking for properties away from the center can also help you save.