San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584

Business Hotels in Central San Diego, San Diego

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Check availability on Central San Diego Business Hotels

Our top choices for Central San Diego business-friendly hotels

3 bars/lounges, lobby lounge, cocktail bar, cocktail bar

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1,718 reviews)
"my favorite hotel i’ve ever been to."
United States
Tianna
The price is P15,138
P17,400 total
includes taxes & fees
Jun 16 - Jun 17
Lafayette Hotel & Club
Exterior

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1,089 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is P10,396
P11,949 total
includes taxes & fees
Jun 30 - Jul 1
Holiday Inn Express San Diego Airport - Old Town by IHG
Property amenity

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
8.2 out of 10, Very Good, (1,052 reviews)
"Always a great stay."
United States
amanda
The price is P7,842
P9,035 total
includes taxes & fees
Jun 29 - Jun 30
Crowne Plaza San Diego - Mission Valley by IHG
Exterior

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
Mission Valley
8.0 out of 10, Very Good, (217 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is P6,422
P7,382 total
includes taxes & fees
Jun 16 - Jun 17
The Alcala Hotel Mission Valley/Seaworld
Library

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego
7.8 out of 10, Good, (1,009 reviews)
"Very good area for visiting the area"
United States
Carla
The price is P6,760
P7,622 total
includes taxes & fees
Jun 17 - Jun 18
Old Town Western Inn & Suites
Property grounds

California Suites Hotel

California Suites Hotel
2.0 star property
Clairemont
7.8 out of 10, Good, (2,648 reviews)
"Had a wonderful stay. Would stay here again"
United States
Ariana
The price is P5,417
P6,216 total
includes taxes & fees
Jun 16 - Jun 17
California Suites Hotel
Outdoor pool, sun loungers

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego
8.4 out of 10, Very Good, (2,064 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is P9,192
P10,566 total
includes taxes & fees
Jun 16 - Jun 17
Best Western Plus Hacienda Hotel Old Town
Free daily full breakfast

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 star property
Mission Valley
8.0 out of 10, Very Good, (2,728 reviews)
"It was a nice clean place for our stay. The staff was super nice and accommodating!"
United States
Shelby
The price is P8,706
P10,006 total
includes taxes & fees
Jun 17 - Jun 18
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Exterior

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego
8.8 out of 10, Excellent, (1,002 reviews)
"Hotel was centrally located to our destination but also to other areas that we visited on our off days. Hotel was clean/quiet, food choices were delicious, and staff was beyond courteous and accommodating!"
United States
Cynthia
The price is P9,250
P10,632 total
includes taxes & fees
Jun 28 - Jun 29
Courtyard by Marriott Old Town
Outdoor pool, pool umbrellas, sun loungers

Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.4 out of 10, Very Good, (2,615 reviews)
"Excellent family hotel"
Mexico
Renata
The price is P6,980
P8,722 total
includes taxes & fees
Jun 29 - Jun 30
Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"The property was perfect it was affordable and very nice. The continental breakfast was good and the pool and hot tub were such fun amenities."
Lidia 4-night trip
Posted less than an hour ago
The Alcala Hotel Mission Valley/Seaworld

Frequently asked questions

Why book your business-friendly hotel in Central San Diego with Expedia?
Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From meeting rooms and conference spaces to on-site restaurants and more, our accommodations have all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Central San Diego?
Click on the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Central San Diego. Then fine-tune your search by your nightly budget. Looking for properties away from the center can also help you save.